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Entity Details
Primary name
IQGA2_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q13576
EntryName
IQGA2_HUMAN
FullName
Ras GTPase-activating-like protein IQGAP2
TaxID
9606
Evidence
evidence at protein level
Length
1575
SequenceStatus
complete
DateCreated
2001-05-04
DateModified
2021-06-02
Ontological Relatives
Genes
IQGAP2
GO terms
Show/Hide Table
GO
Name
GO:0003779
actin binding
GO:0005095
GTPase inhibitor activity
GO:0005096
GTPase activator activity
GO:0005516
calmodulin binding
GO:0005547
phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005874
microtubule
GO:0005886
plasma membrane
GO:0005902
microvillus
GO:0007165
signal transduction
GO:0009986
cell surface
GO:0015629
actin cytoskeleton
GO:0030027
lamellipodium
GO:0030175
filopodium
GO:0030667
secretory granule membrane
GO:0031267
small GTPase binding
GO:0032956
regulation of actin cytoskeleton organization
GO:0034314
Arp2/3 complex-mediated actin nucleation
GO:0043312
neutrophil degranulation
GO:0051015
actin filament binding
GO:0070062
extracellular exosome
GO:0070493
thrombin-activated receptor signaling pathway
GO:0071933
Arp2/3 complex binding
GO:2000249
regulation of actin cytoskeleton reorganization
Subcellular Location
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Domains
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Domain
Name
Category
Type
IPR000048
IQ motif, EF-hand binding site
Site
Binding site
IPR000593
RasGAP protein, C-terminal
Domain
Domain
IPR001202
WW domain
Domain
Domain
IPR001715
Calponin homology domain
Domain
Domain
IPR001936
Ras GTPase-activating domain
Domain
Domain
IPR008936
Rho GTPase activation protein
Family
Homologous superfamily
IPR023152
Ras GTPase-activating protein, conserved site
Site
Conserved site
IPR036872
CH domain superfamily
Family
Homologous superfamily
Diseases
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Drugs
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Interactions
12 interactions
Interactor
Partner
Sources
Publications
Link
IQGA2_HUMAN
CDC42_HUMAN
BioGRID, HPRD, IntAct, MINT
17254974
31478661
31980649
8702968
8756646
details
IQGA2_HUMAN
RAC1_HUMAN
BioGRID, HPRD, IntAct
19961560
27173435
8702968
8756646
unassigned1312
details
IQGA2_HUMAN
RHOG_HUMAN
BioGRID, HPRD
12376551
details
IQGA2_HUMAN
ARP2_HUMAN
HPRD
12515716
details
IQGA2_HUMAN
CALM3_HUMAN
BioGRID, HPRD
27173435
8756646
details
IQGA2_HUMAN
IQGA2_HUMAN
HPRD
12376551
8756646
details
IQGA2_HUMAN
CALM2_HUMAN
BioGRID, HPRD, IntAct
27173435
8756646
unassigned1312
details
IQGA2_HUMAN
CALM1_HUMAN
BioGRID, HPRD
27173435
8756646
details
IQGA2_HUMAN
IKBB_HUMAN
IntAct
14743216
details
IQGA2_HUMAN
MYC_HUMAN
BioGRID, IntAct
17314511
17353931
details
IQGA2_HUMAN
TERA_HUMAN
BioGRID
28970065
details
IQGA2_HUMAN
M3K3_HUMAN
IntAct
14743216
details
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