Entity Details

Primary name DLG1
Entity type gene
Source Source Link

Details

PrimaryID1739
RefseqGeneNG_029099
SymbolDLG1
Namediscs large MAGUK scaffold protein 1
Chromosome3
Location3q29
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1996-06-18
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsDLG1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001771 immunological synapse formation
GO:0001772 immunological synapse
GO:0001935 endothelial cell proliferation
GO:0002088 lens development in camera-type eye
GO:0004385 guanylate kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0007015 actin filament organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007268 chemical synaptic transmission
GO:0008022 protein C-terminus binding
GO:0008092 cytoskeletal protein binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0015459 potassium channel regulator activity
GO:0016032 viral process
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030054 cell junction
GO:0030432 peristalsis
GO:0030838 positive regulation of actin filament polymerization
GO:0030866 cortical actin cytoskeleton organization
GO:0030953 astral microtubule organization
GO:0031253 cell projection membrane
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031579 membrane raft organization
GO:0031594 neuromuscular junction
GO:0031641 regulation of myelination
GO:0032147 activation of protein kinase activity
GO:0033268 node of Ranvier
GO:0034629 cellular protein-containing complex localization
GO:0035748 myelin sheath abaxonal region
GO:0042110 T cell activation
GO:0042130 negative regulation of T cell proliferation
GO:0042383 sarcolemma
GO:0042391 regulation of membrane potential
GO:0042982 amyloid precursor protein metabolic process
GO:0043005 neuron projection
GO:0043113 receptor clustering
GO:0043219 lateral loop
GO:0043268 positive regulation of potassium ion transport
GO:0043622 cortical microtubule organization
GO:0044325 transmembrane transporter binding
GO:0045121 membrane raft
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045296 cadherin binding
GO:0048471 perinuclear region of cytoplasm
GO:0048608 reproductive structure development
GO:0048704 embryonic skeletal system morphogenesis
GO:0048745 smooth muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051660 establishment of centrosome localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0060022 hard palate development
GO:0060090 molecular adaptor activity
GO:0070062 extracellular exosome
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070830 bicellular tight junction assembly
GO:0072659 protein localization to plasma membrane
GO:0097016 L27 domain binding
GO:0097025 MPP7-DLG1-LIN7 complex
GO:0097060 synaptic membrane
GO:0097120 receptor localization to synapse
GO:0098609 cell-cell adhesion
GO:0098839 postsynaptic density membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0098919 structural constituent of postsynaptic density
GO:0098978 glutamatergic synapse
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902473 regulation of protein localization to synapse
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903286 regulation of potassium ion import
GO:1903753 negative regulation of p38MAPK cascade
GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1903764 regulation of potassium ion export across plasma membrane
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000310 regulation of NMDA receptor activity

Diseases

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Interactions

218 interactions

InteractorPartnerSourcesPublicationsLink
DLG1KCNA3BioGRID, HPRD, MINT7477295 9341123 details
DLG1LCKBioGRID, HPRD, IntAct, MINT25241761 9341123 details
DLG1PBKHPRD, MINT10779557 details
DLG1KIF13BBioGRID, HPRD, IntAct10859302 details
DLG1KIF1BBioGRID, HPRD, IntAct, MINT12097473 24550280 29395067 details
DLG1ADAM17BioGRID, HPRD, MINT12668732 18930083 details
DLG1ATP2B2BioGRID, HPRD, IntAct11274188 details
DLG1ASAP1MINT16636290 details
DLG1ANO9IntAct, MINT21525870 24550280 details
DLG1CYSLTR2IntAct, MINT21525870 24550280 26617989 30126976 details
DLG1MAP2K2MINT21615688 details
DLG1MAPK12BioGRID, HPRD, IntAct16637659 25241761 27416801 30126976 details
DLG1BTRCBioGRID, IntAct12902344 details
DLG1ADGRA2BioGRID, IntAct, MINT15021905 24550280 details
DLG1ADGRA3HPRD, IntAct, MINT15021905 24550280 details
DLG1KCNA5BioGRID, HPRD, MINT12970345 16466689 24550280 details
DLG1CTNND2IntAct, MINT24550280 30126976 details
DLG1NXPE2MINT24550280 details
DLG1RALBP1BioGRID, IntAct, MINT24550280 30126976 31980649 details
DLG1EXOC4MINT24550280 details
DLG1RASSF6MINT24550280 details
DLG1FRMPD4IntAct, MINT24550280 30126976 details
DLG1SLCO1C1MINT24550280 details
DLG1SCN5AHPRD, MINT16637659 24550280 details
DLG1GRIN2BBioGRID, HPRD, IntAct, MINT11997254 24550280 30126976 8601796 details
DLG1PRR5IntAct, MINT24550280 30126976 details
DLG1RLIMMINT24550280 details
DLG1PKP4IntAct, MINT24550280 30126976 details
DLG1IQSEC1MINT24550280 details
DLG1ZSCAN30MINT24550280 details
DLG1PLAC8L1MINT24550280 details
DLG1ERBB4BioGRID, HPRD, MINT12175853 24550280 details
DLG1DCUN1D1MINT24550280 details
DLG1FAM163AMINT24550280 details
DLG1MARCHF3MINT24550280 details
DLG1NET1BioGRID, IntAct, MINT17938206 19586902 24550280 30126976 32203420 details
DLG1FAM163BIntAct, MINT24550280 30126976 details
DLG1TBX15MINT24550280 details
DLG1CRIPTBioGRID, HPRD, MINT12070168 18951956 24550280 details
DLG1ADGRA1MINT24550280 details
DLG1KCNA4BioGRID, HPRD, MINT11997254 12860415 24550280 7477295 8938729 details
DLG1KCNJ12BioGRID, HPRD, MINT11181181 14960569 15024025 24550280 5024025 details
DLG1EZRBioGRID, HPRD, IntAct11726633 29568061 34079125 details
DLG1MCCIntAct30126976 details
DLG1RPS6KA2IntAct30126976 details
DLG1TANC1HPRD, IntAct15673434 30126976 details
DLG1ADAM22IntAct30126976 details
DLG1ANO2IntAct30126976 details
DLG1GRIN2CIntAct30126976 details
DLG1EVI5IntAct30126976 details
DLG1WDR20IntAct30126976 details
DLG1CALHM3IntAct30126976 details
DLG1LINC02210-CRHR1IntAct30126976 details
DLG1CRHR1BioGRID, IntAct23576434 30126976 details
DLG1ARHGEF16BioGRID, IntAct30126976 32203420 details
DLG1SEC14L3IntAct30126976 details
DLG1GUCY1A2BioGRID, HPRD, IntAct11572861 30126976 details
DLG1SLC16A3IntAct30126976 details
DLG1IQSEC2IntAct30126976 details
DLG1VANGL2IntAct30126976 details
DLG1VANGL1IntAct30126976 details
DLG1HEATR5BIntAct30126976 details
DLG1APCIntAct23185543 30126976 details
DLG1MTMR1IntAct30126976 details
DLG1GRIN2DIntAct30126976 details
DLG1RAPSNIntAct30126976 details
DLG1PABPN1IntAct30126976 details
DLG1LRRC3CIntAct30126976 details
DLG1CD1DIntAct30126976 details
DLG1MRPS34HPRD, IntAct12507520 30126976 details
DLG1SSBP2IntAct30126976 details
DLG1TPBGLIntAct30126976 details
DLG1HTR2CIntAct30126976 details
DLG1SLC1A1IntAct30126976 details
DLG1KCNJ18IntAct30126976 details
DLG1KCNJ2BioGRID, HPRD, IntAct11181181 30126976 details
DLG1TMEM178AIntAct30126976 details
DLG1DEFB116IntAct30126976 details
DLG1ADAM10BioGRID, UniProt17301176 25036101 details
DLG1KCNJ4BioGRID, HPRD11181181 14960569 15024025 details
DLG1CASKBioGRID, HPRD10993877 12151521 12351654 14960569 23864692 25852190 details
DLG1GRIN2ABioGRID, HPRD10336672 12933808 8601796 details
DLG1CAMK2ABioGRID12933808 details
DLG1GRIA1BioGRID, HPRD11567040 12933808 23864692 9677374 details
DLG1EPB41BioGRID, HPRD7937897 details
DLG1ATP2B4BioGRID, HPRD11274188 12511555 details
DLG1DLGAP1BioGRID, HPRD11060025 9024696 9115257 9286858 details
DLG1KCNJ6BioGRID, HPRD10619846 details
DLG1TJAP1BioGRID, HPRD11602598 details
DLG1LRRC1BioGRID, HPRD11440998 details
DLG1UBE3ABioGRID16482544 details
DLG1KHDRBS1BioGRID22745667 details
DLG1ADGRB1BioGRID23782696 details
DLG1TGFABioGRID18930083 details
DLG1PTENBioGRID, HPRD10646847 11439092 11707428 details
DLG1DLG1BioGRID, HPRD10788497 11602598 details
DLG1GRIN1BioGRID23864692 details
DLG1HTR2ABioGRID24989932 details
DLG1SSTR1BioGRID18951956 details
DLG1LRP2HPRD12713445 details
DLG1MYO6HPRD12050163 details
DLG1BEGAINHPRD9756850 details
DLG1SEMA4CHPRD11134026 details
DLG1DLGAP4HPRD9115257 details
DLG1FZD7HPRD12067714 details
DLG1FZD4HPRD12067714 details
DLG1WNT3AHPRD12067714 details
DLG1KCNA1HPRD7477295 details
DLG1KCNA2HPRD7477295 details
DLG1DLGAP3HPRD9115257 details
DLG1MAP3K3IntAct14743216 details
DLG1PRKNBioGRID, HPRD, IntAct16637659 25241761 details
DLG1LIN7ABioGRID, IntAct14960569 24366813 details
DLG1DLG3BioGRID, HPRD, IntAct12351654 26496610 details
DLG1LIN7CBioGRID, IntAct14960569 26186194 28514442 details
DLG1APBA1BioGRID14960569 details
DLG1ACTN2BioGRID, HPRD12860415 details
DLG1CACNG2BioGRID, HPRD11140673 16637659 details
DLG1GRIK2BioGRID, HPRD11279111 9808460 details
DLG1CTNNA1BioGRID, HPRD9512503 details
DLG1MARCHF2BioGRID17980554 details
DLG1KCNC1BioGRID19213956 details
DLG1MAP1ABioGRID, HPRD9786987 details
DLG1MPP2BioGRID, HPRD12351654 28514442 details
DLG1GJB1BioGRID30401746 details
DLG1STX4BioGRID, HPRD18793635 34079125 details
DLG1KCNAB1HPRD9341123 details
DLG1KCNJ10HPRD9148889 details
DLG1DLG2HPRD12351654 details
DLG1AKAP5HPRD10939335 details
DLG1GDAHPRD10595517 details
DLG1CALM2HPRD12189141 details
DLG1ACTA1HPRD9512503 details
DLG1WASHPRD15699074 details
DLG1GNG13HPRD16473877 details
DLG1SCN4AHPRD16637659 details
DLG1CNKSR2HPRD16637659 details
DLG1GLS2HPRD16637659 details
DLG1PAX6HPRD16637659 details
DLG1BCRHPRD16825666 details
DLG1ADRB1HPRD16316992 details
DLG1AMOTBioGRID, IntAct19615732 details
DLG1AXIN1IntAct22682247 details
DLG1ZMYM1IntAct25852190 details
DLG1KIF26BBioGRID, IntAct26496610 details
DLG1TMEM17BioGRID, IntAct26638075 details
DLG1TUBA1AIntAct27291054 details
DLG1PLEKHA7IntAct28877994 details
DLG1EFNB3BioGRID, IntAct28514442 details
DLG1GJB7BioGRID, IntAct28514442 details
DLG1PRDM1BioGRID, IntAct28514442 details
DLG1GPRC5BBioGRID, IntAct28514442 details
DLG1PIK3CADIP25253337 details
DLG1PIK3R1DIP25253337 details
DLG1PIK3R2DIP25253337 details
DLG1LAMP1BioGRID, IntAct29568061 34079125 details
DLG1TGOLN2BioGRID, IntAct29568061 details
DLG1HNRNPUBioGRID, IntAct30021884 details
DLG1PRNPBioGRID, UniProt29791485 details
DLG1MAS1IntAct26617989 details
DLG1ADRA1DIntAct26617989 details
DLG1ESR1BioGRID, IntAct31527615 details
DLG1RNF146MINT21799911 details
DLG1ARHGEF26BioGRID, IntAct32203420 details
DLG1DISC1BioGRID, MINT29961565 details
DLG1HUWE1BioGRID25147182 details
DLG1NTRK1BioGRID25921289 details
DLG1CDH1BioGRID25468996 details
DLG1PTPREBioGRID27880917 details
DLG1WWC1BioGRID28720576 details
DLG1KRASBioGRID27684187 30442766 34079125 details
DLG1ESR2BioGRID29509190 details
DLG1HRASBioGRID30442766 30639242 details
DLG1NRASBioGRID30442766 30639242 details
DLG1RNF144ABioGRID29212245 details
DLG1PPP1CCBioGRID30344098 details
DLG1DUSP10BioGRID28675297 details
DLG1MTMR2BioGRID25659891 28675297 details
DLG1CTBP2BioGRID30585266 details
DLG1KIF14BioGRID31586073 details
DLG1MAFBBioGRID31822558 details
DLG1NUPR1BioGRID32780723 details
DLG1FAM20CBioGRID32149426 details
DLG1DNAJC5BBioGRID33957083 details
DLG1DNAJC5BioGRID33957083 details
DLG1HSPA12ABioGRID33957083 details
DLG1ARF6BioGRID34079125 details
DLG1B3GAT1BioGRID34079125 details
DLG1C11orf52BioGRID34079125 details
DLG1CAV1BioGRID34079125 details
DLG1CTNNB1BioGRID34079125 details
DLG1CXADRBioGRID34079125 details
DLG1DIRAS3BioGRID34079125 details
DLG1EBAG9BioGRID34079125 details
DLG1EPB41L4ABioGRID34079125 details
DLG1FLOT1BioGRID34079125 details
DLG1GJA1BioGRID34079125 details
DLG1GJD3BioGRID34079125 details
DLG1LAMP2BioGRID34079125 details
DLG1LAMP3BioGRID34079125 details
DLG1LAMTOR1BioGRID34079125 details
DLG1LYNBioGRID34079125 details
DLG1MARCKSBioGRID34079125 details
DLG1AFDNBioGRID34079125 details
DLG1OCLNBioGRID34079125 details
DLG1PARD3BioGRID34079125 details
DLG1RAB11ABioGRID34079125 details
DLG1RAB2ABioGRID34079125 details
DLG1RAB35BioGRID34079125 details
DLG1RAB5ABioGRID34079125 details
DLG1RAB5CBioGRID34079125 details
DLG1RAB9ABioGRID34079125 details
DLG1RHOBBioGRID34079125 details
DLG1STX6BioGRID34079125 details
DLG1STX7BioGRID34079125 details
DLG1ZFPL1BioGRID34079125 details
DLG1HNRNPLBioGRID28611215 details
DLG1MKRN2BioGRID32460013 details