Entity Details

Primary name ABCA1
Entity type gene
Source Source Link

Details

PrimaryID19
RefseqGeneNG_007981
SymbolABCA1
NameATP binding cassette subfamily A member 1
Chromosome9
Location9q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-30
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsABCA1_HUMAN

GO terms

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GOName
GO:0005102 signaling receptor binding
GO:0005319 lipid transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006869 lipid transport
GO:0007040 lysosome organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008203 cholesterol metabolic process
GO:0008320 protein transmembrane transporter activity
GO:0009306 protein secretion
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015485 cholesterol binding
GO:0016197 endosomal transport
GO:0019222 regulation of metabolic process
GO:0019905 syntaxin binding
GO:0023061 signal release
GO:0030139 endocytic vesicle
GO:0030522 intracellular receptor signaling pathway
GO:0031210 phosphatidylcholine binding
GO:0031267 small GTPase binding
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043691 reverse cholesterol transport
GO:0045121 membrane raft
GO:0045332 phospholipid translocation
GO:0045335 phagocytic vesicle
GO:0046623 sphingolipid floppase activity
GO:0048471 perinuclear region of cytoplasm
GO:0051117 ATPase binding
GO:0055091 phospholipid homeostasis
GO:0060155 platelet dense granule organization
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071806 protein transmembrane transport
GO:0090107 regulation of high-density lipoprotein particle assembly
GO:0090108 positive regulation of high-density lipoprotein particle assembly
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0097708 intracellular vesicle
GO:0120020 cholesterol transfer activity
GO:0140115 export across plasma membrane
GO:0140328 floppase activity

Diseases

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Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
ABCA1SNTB2BioGRID, HPRD, IntAct, MINT12054535 16192269 details
ABCA1SNTB1HPRD, IntAct16192269 16192270 16192292 details
ABCA1SNTA1HPRD, IntAct14722086 16192269 16192274 details
ABCA1DLG3HPRD, IntAct16192269 16192271 details
ABCA1ARHGEF11HPRD, IntAct16192269 16192272 details
ABCA1ARHGEF12HPRD, IntAct16192269 16192274 details
ABCA1MPDZHPRD, IntAct16192269 details
ABCA1DLG2HPRD, IntAct16192269 16192276 details
ABCA1LIN7BHPRD, IntAct16192269 16192277 details
ABCA1IKBKGBioGRID, IntAct21988832 details
ABCA1TGM2BioGRID, IntAct21988832 details
ABCA1APOA1bhf-ucl, BioGRID, HPRD, IntAct12084722 27017521 30458687 details
ABCA1FADDBioGRID, HPRD12235128 details
ABCA1UGP2BioGRID, HPRD12054535 details
ABCA1SDHBBioGRID, HPRD12054535 details
ABCA1AOX1BioGRID, HPRD12054535 details
ABCA1PRPF8BioGRID12054535 details
ABCA1CSNK2A2BioGRID15218032 details
ABCA1LNX1BioGRID22889411 details
ABCA1ATXN10BioGRID16498633 details
ABCA1ERBINBioGRID15123239 details
ABCA1TRIM27HPRD12054535 details
ABCA1SLC25A34HPRD12054535 details
ABCA1CDC42bhf-ucl, BioGRID16443932 details
ABCA1STX12bhf-ucl, BioGRID15469992 details
ABCA1FLOT1bhf-ucl, BioGRID15469992 details
ABCA1ABCA12bhf-ucl23931754 details
ABCA1NR1H2bhf-ucl, BioGRID20951680 23931754 25838426 details
ABCA1CANXDIP25170080 details
ABCA1SPTLC1BioGRID, DIP, HPRD18484747 25170080 details
ABCA1DISC1IntAct31413325 details
ABCA1HGSBioGRID21520210 details
ABCA1COPS5BioGRID19268428 details
ABCA1COPS2BioGRID19268428 27017521 details
ABCA1RELABioGRID25331947 details
ABCA1PRKACAHPRD12196520 details
ABCA1CSNK2A1HPRD15218032 details
ABCA1PLTPHPRD14559902 details
ABCA1LIN7CHPRD16192275 details
ABCA1LIN7AHPRD14722086 16192278 details
ABCA1SHANK1HPRD16192279 details
ABCA1DLG5HPRD16192281 details
ABCA1PDZK1HPRD16192282 details
ABCA1LIMK1HPRD16192283 details
ABCA1GOPCHPRD16192284 details
ABCA1LMO7HPRD16192285 details
ABCA1PDLIM4HPRD16192286 details
ABCA1TIAM1HPRD16192287 details
ABCA1RAPGEF6HPRD16192288 details
ABCA1RIMS2HPRD16192289 details
ABCA1PALS2HPRD16192290 details
ABCA1PDLIM3HPRD16192291 details
ABCA1DTNBIntAct16192269 details
ABCA1UTRNDIP, IntAct16192269 25170080 details
ABCA1KIF11DIP25170080 details
ABCA1FLNADIP25170080 details
ABCA1DMDDIP25170080 details
ABCA1CD81IntAct32900848 details
ABCA1FUSBioGRID25192599 details
ABCA1EGFRBioGRID28065597 details
ABCA1IMMP1LBioGRID31617661 details