Entity Details

Primary name LRP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14114
EntryNameLRP8_HUMAN
FullNameLow-density lipoprotein receptor-related protein 8
TaxID9606
Evidenceevidence at protein level
Length963
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesLRP8

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0001540 amyloid-beta binding
GO:0004888 transmembrane signaling receptor activity
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005509 calcium ion binding
GO:0005615 extracellular space
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0006508 proteolysis
GO:0006629 lipid metabolic process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007268 chemical synaptic transmission
GO:0008035 high-density lipoprotein particle binding
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019894 kinesin binding
GO:0021517 ventral spinal cord development
GO:0021541 ammon gyrus development
GO:0021819 layer formation in cerebral cortex
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0030424 axon
GO:0030425 dendrite
GO:0032793 positive regulation of CREB transcription factor activity
GO:0034185 apolipoprotein binding
GO:0038024 cargo receptor activity
GO:0038025 reelin receptor activity
GO:0038026 reelin-mediated signaling pathway
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045088 regulation of innate immune response
GO:0047485 protein N-terminus binding
GO:0048306 calcium-dependent protein binding
GO:0048813 dendrite morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0071363 cellular response to growth factor stimulus
GO:0071397 cellular response to cholesterol
GO:1900006 positive regulation of dendrite development

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeatRepeatRepeat
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved siteSiteConserved site
IPR036055 LDL receptor-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
608446 OMIMMyocardial infarction 1 (MCI1)A condition defined by the irreversible necrosis of heart muscle secondary to prolonged ischemia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
LRP8_HUMANAPOE_HUMANbhf-ucl, BioGRID, HPRD, IntAct12167620 12950167 32814053 8626535 details
LRP8_HUMANAMRP_HUMANBioGRID, DIP, HPRD, IntAct10231386 12899622 16101684 20223215 28514442 details
LRP8_HUMANAPC_HUMANDIP19116273 details
LRP8_HUMANNECA3_HUMANIntAct32814053 details
LRP8_HUMANCRCT1_HUMANIntAct32814053 details
LRP8_HUMANGGA1_HUMANIntAct32814053 details
LRP8_HUMANKAT5_HUMANIntAct32814053 details
LRP8_HUMANTHIO_HUMANIntAct32814053 details
LRP8_HUMANM3K5_HUMANIntAct32814053 details
LRP8_HUMANCTNB1_HUMANIntAct32814053 details
LRP8_HUMANKC1D_HUMANIntAct32814053 details
LRP8_HUMANAPLP2_HUMANIntAct32814053 details
LRP8_HUMANRELN_HUMANBioGRID, HPRD10571240 12167620 12670700 12899622 17548821 21844191 23951306 28446613 details
LRP8_HUMANGIPC1_HUMANBioGRID10827173 details
LRP8_HUMANJIP1_HUMANBioGRID10827173 10827199 details
LRP8_HUMANDLG4_HUMANBioGRID, HPRD10827173 16332682 details
LRP8_HUMANJIP2_HUMANBioGRID10827173 10827199 details
LRP8_HUMANSYJ2B_HUMANBioGRID10827173 details
LRP8_HUMANCAPON_HUMANBioGRID10827173 details
LRP8_HUMANSCN3A_HUMANBioGRID10827173 details
LRP8_HUMANAPBA2_HUMANBioGRID10827173 details
LRP8_HUMANDAB1_HUMANBioGRID, HPRD10380922 10827173 10827199 16481437 details
LRP8_HUMANITBP1_HUMANBioGRID10827173 details
LRP8_HUMANAPC10_HUMANBioGRID10827173 details
LRP8_HUMANSNX17_HUMANBioGRID, HPRD12169628 24705369 details
LRP8_HUMANMYLIP_HUMANBioGRID22109552 details
LRP8_HUMANMK_HUMANBioGRID12573468 details
LRP8_HUMANDAB2_HUMANBioGRID16101684 details
LRP8_HUMANVLDLR_HUMANBioGRID30873003 details
LRP8_HUMANLRP8_HUMANBioGRID30873003 details
LRP8_HUMANAPBA1_HUMANBioGRID17428983 details
LRP8_HUMANSSXT_HUMANIntAct20195357 details
LRP8_HUMANVGFR2_HUMANDIP30139844 details
LRP8_HUMANAPOH_HUMANBioGRID, HPRD12807892 details
LRP8_HUMANNMDZ1_HUMANBioGRID, HPRD16332682 details
LRP8_HUMANAPBB1_HUMANBioGRID17428983 details
LRP8_HUMANA4_HUMANBioGRID17428983 details
LRP8_HUMANCLUS_HUMANHPRD12824284 details