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Entity Details
Primary name
MDC1_HUMAN
Entity type
UniProt
Source
Source Link
Details
Accession
Q14676
EntryName
MDC1_HUMAN
FullName
Mediator of DNA damage checkpoint protein 1
TaxID
9606
Evidence
evidence at protein level
Length
2089
SequenceStatus
complete
DateCreated
2005-07-05
DateModified
2021-06-02
Ontological Relatives
Genes
MDC1
GO terms
Show/Hide Table
GO
Name
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005694
chromosome
GO:0005925
focal adhesion
GO:0006302
double-strand break repair
GO:0006303
double-strand break repair via nonhomologous end joining
GO:0008022
protein C-terminus binding
GO:0016604
nuclear body
GO:0031573
mitotic intra-S DNA damage checkpoint signaling
GO:0070975
FHA domain binding
Subcellular Location
Show/Hide Table
Subcellular Location
Chromosome
Nucleus
Domains
Show/Hide Table
Domain
Name
Category
Type
IPR000253
Forkhead-associated (FHA) domain
Domain
Domain
IPR001357
BRCT domain
Domain
Domain
IPR008984
SMAD/FHA domain superfamily
Family
Homologous superfamily
IPR036420
BRCT domain superfamily
Family
Homologous superfamily
Diseases
Show/Hide Table
Drugs
Show/Hide Table
Interactions
74 interactions
Interactor
Partner
Sources
Publications
Link
MDC1_HUMAN
NBN_HUMAN
BioGRID, DIP, HPRD, IntAct, MINT, UniProt
12607003
12607005
14519663
15201865
15377652
18001824
18583988
18678890
19804756
20224574
20460517
23115235
25064736
29656893
30179224
details
MDC1_HUMAN
RAD50_HUMAN
BioGRID, MINT, UniProt
12607003
12607005
14519663
18583988
29656893
30179224
details
MDC1_HUMAN
ATM_HUMAN
BioGRID, HPRD, UniProt
12607005
14519663
18006705
26734725
28943310
29656893
details
MDC1_HUMAN
TP53B_HUMAN
BioGRID, HPRD, UniProt
12607005
17925396
18986980
29656893
30179224
details
MDC1_HUMAN
MRE11_HUMAN
BioGRID, MINT, UniProt
12607003
12607005
14519663
18583988
29656893
30179224
details
MDC1_HUMAN
H2AX_HUMAN
BioGRID, DIP, HPRD, IntAct, MINT, UniProt
12475977
12607005
14519663
15201865
16377563
18001824
18001825
18583988
19234442
20159462
21293379
21622030
21676867
26734725
28242625
29499138
30598506
32518374
details
MDC1_HUMAN
RNF8_HUMAN
BioGRID, DIP, HPRD, IntAct
18001824
18001825
18006705
24240613
25512560
26734725
28943310
details
MDC1_HUMAN
CSK21_HUMAN
BioGRID, MINT
18583988
details
MDC1_HUMAN
LYOX_HUMAN
matrixdb
25118846
details
MDC1_HUMAN
RAD51_HUMAN
BioGRID, DIP
16186822
28973861
details
MDC1_HUMAN
NSD2_HUMAN
BioGRID, DIP
21293379
31248990
details
MDC1_HUMAN
UIMC1_HUMAN
BioGRID, DIP, UniProt
21622030
21857162
22990118
24240613
29656893
details
MDC1_HUMAN
TOPB1_HUMAN
BioGRID, UniProt
21482717
24239288
29656893
details
MDC1_HUMAN
BKRB1_HUMAN
BioGRID, MINT
28298427
details
MDC1_HUMAN
CENPC_HUMAN
BioGRID
14578343
details
MDC1_HUMAN
GATA4_HUMAN
BioGRID
14578343
details
MDC1_HUMAN
HDA10_HUMAN
BioGRID
14578343
details
MDC1_HUMAN
HDAC8_HUMAN
BioGRID
14578343
details
MDC1_HUMAN
MDM2_HUMAN
BioGRID
14578343
18471438
details
MDC1_HUMAN
RPB1_HUMAN
BioGRID
14578343
22990118
details
MDC1_HUMAN
WRN_HUMAN
BioGRID
14578343
details
MDC1_HUMAN
CHK2_HUMAN
BioGRID, HPRD
12475977
12551934
12607004
details
MDC1_HUMAN
APC1_HUMAN
BioGRID
17827148
19826003
22990118
details
MDC1_HUMAN
CDC27_HUMAN
BioGRID
17827148
19826003
22942284
details
MDC1_HUMAN
CASP3_HUMAN
BioGRID
21148072
details
MDC1_HUMAN
PRKDC_HUMAN
BioGRID
15377652
details
MDC1_HUMAN
XRCC5_HUMAN
BioGRID
15377652
details
MDC1_HUMAN
PIAS1_HUMAN
BioGRID
22661230
details
MDC1_HUMAN
PIAS4_HUMAN
BioGRID
22661230
details
MDC1_HUMAN
CDC20_HUMAN
BioGRID
19826003
22990118
details
MDC1_HUMAN
CBP_HUMAN
BioGRID, HPRD
16051665
19826003
details
MDC1_HUMAN
HINFP_HUMAN
BioGRID
17577209
details
MDC1_HUMAN
AMFR_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
AUP1_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
CLUS_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
PRI1_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
RL29_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
VAMP5_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
CSN5_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
ZN251_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
DTX2_HUMAN
BioGRID
22990118
details
MDC1_HUMAN
NUCL_HUMAN
BioGRID
23145133
details
MDC1_HUMAN
SUMO2_HUMAN
BioGRID
19394292
32786267
details
MDC1_HUMAN
SRPK2_HUMAN
BioGRID
26167880
details
MDC1_HUMAN
UBP13_HUMAN
BioGRID
28569838
details
MDC1_HUMAN
UBP7_HUMAN
BioGRID
30179224
details
MDC1_HUMAN
TNKS1_HUMAN
BioGRID
26845027
details
MDC1_HUMAN
TNKS2_HUMAN
BioGRID
26845027
details
MDC1_HUMAN
UBP15_HUMAN
BioGRID
30874560
details
MDC1_HUMAN
PTEN_HUMAN
BioGRID
31217297
details
MDC1_HUMAN
BRCA1_HUMAN
BioGRID, HPRD, IntAct, UniProt
12607005
12611903
15569676
17525332
19766185
21622030
29656893
details
MDC1_HUMAN
MDC1_HUMAN
BioGRID, DIP, HPRD, UniProt
12607005
14519663
21293379
29656893
details
MDC1_HUMAN
JHD2C_HUMAN
DIP
24240613
details
MDC1_HUMAN
BARD1_HUMAN
BioGRID, HPRD, UniProt
12611903
29656893
details
MDC1_HUMAN
P53_HUMAN
BioGRID, HPRD
14519663
details
MDC1_HUMAN
UBP28_HUMAN
BioGRID, HPRD
16901786
details
MDC1_HUMAN
BAF_HUMAN
BioGRID
19759913
details
MDC1_HUMAN
MCPH1_HUMAN
BioGRID
16872911
details
MDC1_HUMAN
APC5_HUMAN
BioGRID
17827148
22990118
details
MDC1_HUMAN
CDC16_HUMAN
BioGRID
17827148
19826003
22990118
details
MDC1_HUMAN
BIRC5_HUMAN
BioGRID
20394854
details
MDC1_HUMAN
HERC2_HUMAN
BioGRID
20023648
details
MDC1_HUMAN
EP300_HUMAN
BioGRID, HPRD
16051665
details
MDC1_HUMAN
RNF4_HUMAN
BioGRID
22661230
details
MDC1_HUMAN
PSMD4_HUMAN
BioGRID
22661229
details
MDC1_HUMAN
APC7_HUMAN
BioGRID
19826003
22990118
details
MDC1_HUMAN
RAG1_HUMAN
BioGRID
22942284
details
MDC1_HUMAN
TCAB1_HUMAN
BioGRID
25512560
26734725
27715493
details
MDC1_HUMAN
ATX3_HUMAN
BioGRID
28275011
details
MDC1_HUMAN
ASF1A_HUMAN
BioGRID
28943310
details
MDC1_HUMAN
CTCF_HUMAN
BioGRID
28973861
details
MDC1_HUMAN
TRI29_HUMAN
BioGRID
26095369
details
MDC1_HUMAN
SENP2_HUMAN
BioGRID
30796017
details
MDC1_HUMAN
SYCP3_HUMAN
BioGRID
31043422
details
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