Entity Details

Primary name GRID2
Entity type gene
Source Source Link

Details

PrimaryID2895
RefseqGeneNG_034113
SymbolGRID2
Nameglutamate ionotropic receptor delta type subunit 2
Chromosome4
Location4q22.1-q22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-05-14
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsGRID2_HUMAN

GO terms

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GOName
GO:0004970 ionotropic glutamate receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007215 glutamate receptor signaling pathway
GO:0008066 glutamate receptor activity
GO:0008328 ionotropic glutamate receptor complex
GO:0010975 regulation of neuron projection development
GO:0015276 ligand-gated ion channel activity
GO:0021707 cerebellar granule cell differentiation
GO:0030165 PDZ domain binding
GO:0034613 cellular protein localization
GO:0035249 synaptic transmission, glutamatergic
GO:0038023 signaling receptor activity
GO:0043197 dendritic spine
GO:0043523 regulation of neuron apoptotic process
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050804 modulation of chemical synaptic transmission
GO:0051965 positive regulation of synapse assembly
GO:0060079 excitatory postsynaptic potential
GO:0060134 prepulse inhibition
GO:0097110 scaffold protein binding
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane
GO:0099151 regulation of postsynaptic density assembly
GO:1900454 positive regulation of long-term synaptic depression
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:1904861 excitatory synapse assembly

Diseases

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Disease IDSourceNameDescription
616204 OMIMSpinocerebellar ataxia, autosomal recessive, 18 (SCAR18)A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR18 features include progressive cerebellar atrophy, delayed psychomotor development, severely impaired gait, ocular movement abnormalities, and intellectual disability. The disease is caused by variants affecting the gene represented in this entry.

Interactions

11 interactions