Entity Details

Primary name HFE
Entity type gene
Source Source Link

Details

PrimaryID3077
RefseqGeneNG_008720
SymbolHFE
Namehomeostatic iron regulator
Chromosome6
Location6p22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-17
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHFE_HUMAN

GO terms

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GOName
GO:0002626 negative regulation of T cell antigen processing and presentation
GO:0002725 negative regulation of T cell cytokine production
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006879 cellular iron ion homeostasis
GO:0006953 acute-phase response
GO:0007565 female pregnancy
GO:0009897 external side of plasma membrane
GO:0010039 response to iron ion
GO:0010106 cellular response to iron ion starvation
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0030881 beta-2-microglobulin binding
GO:0031410 cytoplasmic vesicle
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033572 transferrin transport
GO:0034756 regulation of iron ion transport
GO:0039706 co-receptor binding
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055072 iron ion homeostasis
GO:0065003 protein-containing complex assembly
GO:0071281 cellular response to iron ion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097421 liver regeneration
GO:0098711 iron ion import across plasma membrane
GO:1900121 negative regulation of receptor binding
GO:1900122 positive regulation of receptor binding
GO:1904283 negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:1904434 positive regulation of ferrous iron binding
GO:1904437 positive regulation of transferrin receptor binding
GO:1990357 terminal web
GO:1990459 transferrin receptor binding
GO:1990641 response to iron ion starvation
GO:1990712 HFE-transferrin receptor complex
GO:2000008 regulation of protein localization to cell surface
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000272 negative regulation of signaling receptor activity
GO:2000273 positive regulation of signaling receptor activity
GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
HFETFRCBioGRID, DIP, HPRD, MINT, UniProt11027676 14691533 15965644 20133674 20618438 9465039 details
HFEHSPA5MINT20618438 details
HFETFMINT20618438 details
HFEB2MBioGRID, DIP, HPRD, MINT, UniProt10638746 10791995 15965644 20618438 details
HFESYVN1BioGRID21245296 details
HFETFR2HPRD10638746 9465039 details