Entity Details

Primary name MAP3K3
Entity type gene
Source Source Link

Details

PrimaryID4215
RefseqGene
SymbolMAP3K3
Namemitogen-activated protein kinase kinase kinase 3
Chromosome17
Location17q23.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-15
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsM3K3_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0035556 intracellular signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900745 positive regulation of p38MAPK cascade
GO:2000773 negative regulation of cellular senescence

Diseases

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Interactions

219 interactions

InteractorPartnerSourcesPublicationsLink
MAP3K3MAP3K2BioGRID, IntAct14743216 24975362 26496610 details
MAP3K3MAP3K3BioGRID, HPRD, IntAct10593883 14743216 15001576 16407301 details
MAP3K3YWHAEBioGRID, HPRD, IntAct, MINT12392720 14743216 16407301 9452471 details
MAP3K3MAP2K5BioGRID, IntAct11073940 12813044 14743216 16861740 19903815 24975362 25241761 28514442 details
MAP3K3ZBTB16BioGRID, HPRD, IntAct16169070 details
MAP3K3PPP2R5AMINT16407301 details
MAP3K3PPP2R5DMINT16407301 details
MAP3K3MAPK1MINT16407301 details
MAP3K3MAPK3MINT16407301 details
MAP3K3COPS5BioGRID, IntAct20936779 details
MAP3K3VWFBioGRID, IntAct20936779 details
MAP3K3GTF2IBioGRID, IntAct21988832 details
MAP3K3TOM1L1BioGRID, MINT21900206 details
MAP3K3TRAF6BioGRID, HPRD, IntAct14661019 19843958 19903815 25241761 details
MAP3K3EGFRBioGRID, IntAct24658140 25402006 31980649 details
MAP3K3CCM2DIP25982527 27027284 details
MAP3K3GLRX3BioGRID, IntAct25416956 29892012 details
MAP3K3BRCA1BioGRID, HPRD15205325 details
MAP3K3GAB1BioGRID, HPRD12065326 details
MAP3K3SQSTM1BioGRID19843958 19903815 details
MAP3K3NEDD4BioGRID19953087 details
MAP3K3NEDD4LBioGRID19953087 details
MAP3K3SMURF1BioGRID19318350 details
MAP3K3MAP3K7BioGRID, HPRD16260783 19843958 details
MAP3K3MAP2K4BioGRID25043814 9162092 details
MAP3K3MAP2K3BioGRID9162092 details
MAP3K3XIAPBioGRID24975362 details
MAP3K3BIRC2BioGRID24975362 details
MAP3K3MBPBioGRID24975362 details
MAP3K3MAP2K7BioGRID24975362 details
MAP3K3GLI1BioGRID29662197 details
MAP3K3TRAF7BioGRID, HPRD, IntAct14743216 15001576 details
MAP3K3PFDN1IntAct14743216 details
MAP3K3BAG2IntAct14743216 details
MAP3K3AIFM1IntAct14743216 details
MAP3K3RPAP3IntAct14743216 details
MAP3K3IKBKGIntAct14743216 details
MAP3K3SCINIntAct14743216 details
MAP3K3HSPA1LIntAct14743216 details
MAP3K3CCT8IntAct14743216 details
MAP3K3GNB2IntAct14743216 details
MAP3K3HSPA5IntAct14743216 details
MAP3K3DBN1IntAct14743216 details
MAP3K3DNAJB4IntAct14743216 details
MAP3K3TMOD3IntAct14743216 details
MAP3K3CHUKBioGRID, IntAct14743216 25241761 details
MAP3K3PFDN6IntAct14743216 details
MAP3K3UBL4AIntAct14743216 details
MAP3K3CAPZA1IntAct14743216 details
MAP3K3RPS27LIntAct14743216 details
MAP3K3SLC25A5IntAct14743216 details
MAP3K3HSPA2HPRD, IntAct1474216 14743216 details
MAP3K3BAG5IntAct14743216 details
MAP3K3MARS1IntAct14743216 details
MAP3K3CORO1CIntAct14743216 details
MAP3K3RUVBL2IntAct14743216 details
MAP3K3SUGT1IntAct14743216 details
MAP3K3IQGAP1IntAct14743216 details
MAP3K3RPL23IntAct14743216 details
MAP3K3MYO1CIntAct14743216 details
MAP3K3HAX1IntAct14743216 details
MAP3K3CCT5IntAct14743216 details
MAP3K3EPPK1IntAct14743216 details
MAP3K3PHGDHIntAct14743216 details
MAP3K3MCCIntAct14743216 details
MAP3K3HSPA6IntAct14743216 details
MAP3K3DNAJA1IntAct14743216 details
MAP3K3IARS1IntAct14743216 details
MAP3K3ACTN4IntAct14743216 details
MAP3K3HNRNPH1IntAct14743216 details
MAP3K3MYO1BIntAct14743216 details
MAP3K3C1QBPIntAct14743216 details
MAP3K3EEF1A2IntAct14743216 details
MAP3K3SCO2IntAct14743216 details
MAP3K3SPTAN1IntAct14743216 details
MAP3K3PFDN4IntAct14743216 details
MAP3K3DNAJB1IntAct14743216 details
MAP3K3ATP5F1AIntAct14743216 details
MAP3K3MATR3IntAct14743216 details
MAP3K3TCP1IntAct14743216 details
MAP3K3CCT7IntAct14743216 details
MAP3K3TFGIntAct14743216 details
MAP3K3MYH10IntAct14743216 details
MAP3K3CADIntAct14743216 details
MAP3K3RUVBL1IntAct14743216 details
MAP3K3ACTG1IntAct14743216 details
MAP3K3URI1IntAct14743216 details
MAP3K3VCPIntAct14743216 details
MAP3K3CNOT9IntAct14743216 details
MAP3K3TIMM50IntAct14743216 details
MAP3K3CLTCIntAct14743216 details
MAP3K3IKBKBHPRD, IntAct11429546 14743216 details
MAP3K3STUB1IntAct14743216 details
MAP3K3PPP2R1BIntAct14743216 details
MAP3K3GNAI2IntAct14743216 details
MAP3K3CAPZBIntAct14743216 details
MAP3K3GNB1IntAct14743216 details
MAP3K3FASNIntAct14743216 details
MAP3K3CCT3IntAct14743216 details
MAP3K3XPOTIntAct14743216 details
MAP3K3PLOD1IntAct14743216 details
MAP3K3PPP1CAIntAct14743216 details
MAP3K3CCT6AIntAct14743216 details
MAP3K3PFDN5IntAct14743216 details
MAP3K3TUBB2BIntAct14743216 details
MAP3K3ST13IntAct14743216 details
MAP3K3TUBB6IntAct14743216 details
MAP3K3HSPA8IntAct14743216 details
MAP3K3UBBIntAct14743216 details
MAP3K3NUDCIntAct14743216 details
MAP3K3MYO6IntAct14743216 details
MAP3K3CALM1IntAct14743216 details
MAP3K3CALM2IntAct14743216 details
MAP3K3CALM3IntAct14743216 details
MAP3K3UBA52IntAct14743216 details
MAP3K3S100A8IntAct14743216 details
MAP3K3PPP2R1AIntAct14743216 details
MAP3K3PIH1D1IntAct14743216 details
MAP3K3TUBBIntAct14743216 details
MAP3K3PFKLIntAct14743216 details
MAP3K3RNF126IntAct14743216 details
MAP3K3TUBB4AIntAct14743216 details
MAP3K3CCAR2IntAct14743216 details
MAP3K3MPRIPIntAct14743216 details
MAP3K3SCRIBIntAct14743216 details
MAP3K3UXTIntAct14743216 details
MAP3K3UACAIntAct14743216 details
MAP3K3RAI14IntAct14743216 details
MAP3K3ALKIntAct14743216 details
MAP3K3TUBB3IntAct14743216 details
MAP3K3DNAJA3IntAct14743216 details
MAP3K3RPS27AIntAct14743216 details
MAP3K3FLNABioGRID, IntAct14743216 25241761 details
MAP3K3PPP1R12AIntAct14743216 details
MAP3K3MYH9IntAct14743216 details
MAP3K3LYNIntAct14743216 details
MAP3K3CCT2IntAct14743216 details
MAP3K3SMARCC2IntAct14743216 details
MAP3K3VBP1IntAct14743216 details
MAP3K3VIMIntAct14743216 details
MAP3K3H4-16IntAct14743216 details
MAP3K3H4C15IntAct14743216 details
MAP3K3H4C9IntAct14743216 details
MAP3K3H4C1IntAct14743216 details
MAP3K3H4C4IntAct14743216 details
MAP3K3H4C6IntAct14743216 details
MAP3K3H4C12IntAct14743216 details
MAP3K3H4C11IntAct14743216 details
MAP3K3H4C3IntAct14743216 details
MAP3K3H4C8IntAct14743216 details
MAP3K3H4C2IntAct14743216 details
MAP3K3H4C5IntAct14743216 details
MAP3K3H4C13IntAct14743216 details
MAP3K3H4C14IntAct14743216 details
MAP3K3SPTBN1IntAct14743216 details
MAP3K3SLC25A6IntAct14743216 details
MAP3K3LONP1IntAct14743216 details
MAP3K3PYGMIntAct14743216 details
MAP3K3PPP1CCIntAct14743216 details
MAP3K3TUBA3DIntAct14743216 details
MAP3K3TUBA3CIntAct14743216 details
MAP3K3PRKDCIntAct14743216 details
MAP3K3MYL6IntAct14743216 details
MAP3K3DLG1IntAct14743216 details
MAP3K3DDB1IntAct14743216 details
MAP3K3GAPDHIntAct14743216 details
MAP3K3LGALS7IntAct14743216 details
MAP3K3LGALS7BIntAct14743216 details
MAP3K3SEC16AIntAct14743216 details
MAP3K3S100A7IntAct14743216 details
MAP3K3CFL2IntAct14743216 details
MAP3K3AKAP8LIntAct14743216 details
MAP3K3CPVLIntAct14743216 details
MAP3K3DNAJC7IntAct14743216 details
MAP3K3CCT4IntAct14743216 details
MAP3K3MYO1AIntAct14743216 details
MAP3K3LIMA1IntAct14743216 details
MAP3K3HSP90AB1HPRD, IntAct14743216 details
MAP3K3MYL12AIntAct14743216 details
MAP3K3GNAI3IntAct14743216 details
MAP3K3IQGAP2IntAct14743216 details
MAP3K3RPS16IntAct14743216 details
MAP3K3RPS27IntAct14743216 details
MAP3K3MYLK2IntAct14743216 details
MAP3K3MYO1DIntAct14743216 details
MAP3K3TUBA1AIntAct14743216 details
MAP3K3YWHAZHPRD, IntAct14743216 28514442 details
MAP3K3YWHABHPRD, IntAct, MINT14743216 18308725 28514442 details
MAP3K3YWHAHHPRD, IntAct14743216 28514442 details
MAP3K3YWHAQHPRD, IntAct14743216 28514442 details
MAP3K3HSPA9IntAct14743216 details
MAP3K3HSP90AA1BioGRID, HPRD, IntAct14743216 19560753 details
MAP3K3PRKACABioGRID, HPRD, IntAct12392720 25241761 details
MAP3K3CBY1BioGRID, IntAct27173435 unassigned1312 details
MAP3K3SPAG9BioGRID, HPRD12391307 details
MAP3K3PPP2CABioGRID20448038 details
MAP3K3RIPK1BioGRID, HPRD11429546 details
MAP3K3IRAK1BioGRID17197697 details
MAP3K3NBR1BioGRID25043814 details
MAP3K3MTORBioGRID26279575 details
MAP3K3SUFUBioGRID29662197 details
MAP3K3MAP3K5HPRD12912994 details
MAP3K3RCAN1HPRD16126726 details
MAP3K3NFKBIAHPRD10085062 details
MAP3K3WNK1HPRD14681216 details
MAP3K3HSPA4BioGRID, IntAct14743216 details
MAP3K3YWHAGBioGRID, HPRD, IntAct14743216 28514442 details
MAP3K3PDRG1BioGRID, IntAct14743216 details
MAP3K3CDC37BioGRID, HPRD, IntAct14743216 details
MAP3K3MARK2BioGRID, HPRD, IntAct14743216 details
MAP3K3PFDN2BioGRID, HPRD, IntAct14743216 details
MAP3K3PKMIntAct24606918 details
MAP3K3FUSBioGRID25192599 details
MAP3K3XPO1BioGRID26673895 details
MAP3K3KIFC3BioGRID26496610 details
MAP3K3IP6K3BioGRID26496610 details
MAP3K3CUL7BioGRID31343991 details
MAP3K3BCAR1BioGRID33001583 details
MAP3K3VIRMABioGRID29507755 details