Entity Details

Primary name MK11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15759
EntryNameMK11_HUMAN
FullNameMitogen-activated protein kinase 11
TaxID9606
Evidenceevidence at protein level
Length364
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMAPK11

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001649 osteoblast differentiation
GO:0004674 protein serine/threonine kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007265 Ras protein signal transduction
GO:0010628 positive regulation of gene expression
GO:0032735 positive regulation of interleukin-12 production
GO:0035556 intracellular signal transduction
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060348 bone development
GO:0071347 cellular response to interleukin-1
GO:0098586 cellular response to virus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003527 Mitogen-activated protein (MAP) kinase, conserved siteSiteConserved site
IPR008352 Mitogen-activated protein (MAP) kinase p38-likeFamilyFamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB01017 MinocyclineDrugbanksmall molecule
DB05157 KC706Drugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule

Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
MK11_HUMANP53_HUMANIntAct17254968 details
MK11_HUMANATF2_HUMANBioGRID, HPRD, IntAct, MINT12761180 15304344 17254968 17380123 9235954 details
MK11_HUMANZNHI1_HUMANHPRD, MINT17380123 details
MK11_HUMANMAPK3_HUMANBioGRID, IntAct21988832 23602568 26186194 28514442 details
MK11_HUMANTLS1_HUMANBioGRID, MINT21900206 details
MK11_HUMANCPNE6_HUMANBioGRID, MINT21900206 details
MK11_HUMANMK14_HUMANBioGRID, IntAct, MINT21900206 23602568 details
MK11_HUMANRPC4_HUMANBioGRID, MINT21900206 details
MK11_HUMANSOCS3_HUMANBioGRID, MINT21900206 details
MK11_HUMANCRYA2_HUMANIntAct32814053 details
MK11_HUMANDYHC1_HUMANIntAct32814053 details
MK11_HUMANDYN2_HUMANIntAct32814053 details
MK11_HUMANFGFR3_HUMANIntAct32814053 details
MK11_HUMANPAK1_HUMANIntAct32814053 details
MK11_HUMANKPCA_HUMANIntAct32814053 details
MK11_HUMANKLK6_HUMANIntAct32814053 details
MK11_HUMANSMN_HUMANIntAct32814053 details
MK11_HUMAN1433G_HUMANIntAct32814053 details
MK11_HUMANSETB1_HUMANIntAct32814053 details
MK11_HUMANKAT5_HUMANIntAct32814053 details
MK11_HUMANGIPC1_HUMANIntAct32814053 details
MK11_HUMANLMO3_HUMANIntAct32814053 details
MK11_HUMANTADBP_HUMANIntAct32814053 details
MK11_HUMANHDAC3_HUMANBioGRID, HPRD15356147 details
MK11_HUMANPML_HUMANBioGRID15273249 details
MK11_HUMANCCND1_HUMANBioGRID10952989 details
MK11_HUMANMBP_HUMANBioGRID, HPRD15728454 17906618 details
MK11_HUMANHTRA2_HUMANBioGRID17906618 details
MK11_HUMANA4_HUMANBioGRID21832049 details
MK11_HUMANSH21A_HUMANBioGRID9235954 details
MK11_HUMANNOXA1_HUMANBioGRID20110267 details
MK11_HUMANTAU_HUMANBioGRID15632108 9199504 details
MK11_HUMANPPM1D_HUMANBioGRID28027003 details
MK11_HUMANMAPK2_HUMANBioGRID, IntAct11551945 23602568 details
MK11_HUMANTAB1_HUMANBioGRID, HPRD, IntAct11847341 25241761 details
MK11_HUMANPKN1_HUMANBioGRID12761180 details
MK11_HUMANGYS1_HUMANBioGRID14680475 details
MK11_HUMANEF2K_HUMANHPRD12171600 details
MK11_HUMANMAPK5_HUMANHPRD9628874 details
MK11_HUMANDUS16_HUMANHPRD11359773 details
MK11_HUMANDUS10_HUMANHPRD11359773 details
MK11_HUMANKS6A5_HUMANHPRD9687510 details
MK11_HUMANELK1_HUMANHPRD9235954 details
MK11_HUMANELK4_HUMANHPRD9235954 details
MK11_HUMANJUN_HUMANHPRD9235954 details
MK11_HUMANESR2_HUMANHPRD11579095 details
MK11_HUMANBCL2_HUMANHPRD11495898 details