Entity Details

Primary name MSH2
Entity type gene
Source Source Link

Details

PrimaryID4436
RefseqGeneNG_007110
SymbolMSH2
NamemutS homolog 2
Chromosome2
Location2p21-p16.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMSH2_HUMAN

GO terms

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GOName
GO:0000406 double-strand/single-strand DNA junction binding
GO:0000781 chromosome, telomeric region
GO:0001701 in utero embryonic development
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006119 oxidative phosphorylation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007281 germ cell development
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008584 male gonad development
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0016020 membrane
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019237 centromeric DNA binding
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0032302 MutSbeta complex
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043570 maintenance of DNA repeat elements
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0051096 positive regulation of helicase activity
GO:0071168 protein localization to chromatin

Diseases

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Interactions

219 interactions

InteractorPartnerSourcesPublicationsLink
MSH2EXO1BioGRID, HPRD, IntAct, UniProt10856833 11427529 11429708 12414623 14676842 19015241 22222486 9788596 details
MSH2MSH6BioGRID, DIP, HPRD, IntAct10029069 10748159 10783165 10856833 14657349 15064730 19377479 22939629 25241761 26344197 26496610 8942985 9428522 9774676 details
MSH2MSH3BioGRID, DIP, HPRD, IntAct10029069 14657349 16025128 19377479 22179786 22939629 8805365 8942985 9774676 details
MSH2MSH2BioGRID, IntAct8942985 9774676 details
MSH2MYCBioGRID, IntAct12584560 17314511 28205554 29467282 30415952 details
MSH2SLX4BioGRID, IntAct19596235 22902628 31495888 32398829 details
MSH2ANXA7BioGRID, MINT21900206 details
MSH2CDKN1ABioGRID, MINT21900206 details
MSH2GRB7BioGRID, MINT21900206 details
MSH2RPP14BioGRID, MINT21900206 details
MSH2SMN1BioGRID, MINT21900206 details
MSH2SMN2MINT21900206 details
MSH2TK1BioGRID, MINT21900206 details
MSH2MAXBioGRID, HPRD, IntAct12584560 25241761 details
MSH2AKT1BioGRID, MINT24412244 28205554 details
MSH2CDC14BBioGRID, MINT24412244 27880917 details
MSH2DVL1BioGRID, MINT24412244 details
MSH2FBP1BioGRID, MINT24412244 details
MSH2FBP2BioGRID, MINT24412244 details
MSH2GALNT12BioGRID, MINT24412244 details
MSH2HRASBioGRID, MINT24412244 details
MSH2CCDC180BioGRID, MINT24412244 details
MSH2LEF1BioGRID, MINT24412244 details
MSH2SMAD1BioGRID, MINT24412244 details
MSH2PPP3R2BioGRID, MINT24412244 details
MSH2STX17BioGRID, MINT24412244 details
MSH2TDRD7BioGRID, MINT24412244 details
MSH2ZNF510BioGRID, MINT24412244 details
MSH2APPBP2BioGRID, IntAct32296183 details
MSH2BRCA1BioGRID10783165 11498787 15886699 details
MSH2BARD1BioGRID, HPRD11498787 details
MSH2CHEK2BioGRID, HPRD12447371 15647386 details
MSH2ATRBioGRID, HPRD14657349 21285353 33005030 details
MSH2PCNABioGRID, HPRD12171929 15225546 8858149 details
MSH2XPABioGRID19468048 details
MSH2RPA4BioGRID19468048 details
MSH2ESR1BioGRID15886699 details
MSH2ESR2BioGRID15886699 29509190 details
MSH2HUS1BioGRID20188637 details
MSH2RAD1BioGRID20188637 details
MSH2RAD9ABioGRID20188637 details
MSH2MUTYHBioGRID11801590 details
MSH2HDAC6BioGRID23703321 24882211 details
MSH2SUMO2BioGRID19394292 25533185 32786267 details
MSH2USP10BioGRID26975374 details
MSH2TRIM29BioGRID26095369 details
MSH2EPHA2BioGRID28205554 details
MSH2FGFR4BioGRID28205554 details
MSH2CDC42BioGRID31478661 details
MSH2IKBKGIntAct14743216 details
MSH2MCCIntAct17353931 details
MSH2ARF6IntAct17353931 details
MSH2WRAP73IntAct17353931 details
MSH2MLH1BioGRID, IntAct10748159 10783165 12799449 25241761 30770470 31843968 details
MSH2HMGB1UniProt15014079 details
MSH2RAF1BioGRID, IntAct27173435 31980649 unassigned1312 details
MSH2RPGRIP1LBioGRID, IntAct27173435 unassigned1312 details
MSH2BLMBioGRID10783165 15064730 details
MSH2CHEK1BioGRID15647386 details
MSH2ATMBioGRID10783165 details
MSH2MRE11BioGRID10783165 details
MSH2NBNBioGRID10783165 details
MSH2RAD50BioGRID10783165 details
MSH2RFC1BioGRID10783165 details
MSH2ATRIPBioGRID, HPRD14657349 details
MSH2PMS2BioGRID10748159 12799449 17148452 details
MSH2AIREBioGRID20085707 details
MSH2PRKCZBioGRID15808853 details
MSH2MGMTBioGRID16226712 details
MSH2TP53BioGRID12101417 15064730 32807901 details
MSH2CREBBPBioGRID, HPRD16051665 details
MSH2FANCABioGRID21975120 details
MSH2DTLBioGRID21725088 details
MSH2SMARCAD1BioGRID21549307 31843968 details
MSH2CDK9BioGRID20305087 27684187 details
MSH2NELFBBioGRID20305087 details
MSH2PMS1BioGRID10748159 details
MSH2RAD51BioGRID15064730 details
MSH2XRCC6BioGRID21075794 22863883 details
MSH2FANCD2BioGRID21865299 details
MSH2ERCC1BioGRID14706347 details
MSH2ERCC4BioGRID14706347 details
MSH2POLKBioGRID24038355 details
MSH2REV1BioGRID24038355 details
MSH2SIRT6BioGRID24169447 details
MSH2RNF126BioGRID26508657 details
MSH2MCM9BioGRID26300262 26870752 details
MSH2MCM8BioGRID26300262 details
MSH2RAD18BioGRID27377895 details
MSH2H2AXBioGRID26095369 details
MSH2LRRC31BioGRID33005030 details
MSH2SMC1AHPRD14657349 details
MSH2PTP4A3BioGRID, IntAct17353931 details
MSH2OTUB1BioGRID, IntAct19615732 26752685 details
MSH2SNW1BioGRID, MINT, UniProt12840015 20467437 details
MSH2CDC5LBioGRID, MINT20467437 details
MSH2E2F3BioGRID, IntAct, MINT22157815 25241761 details
MSH2LRRK2IntAct24725412 31046837 details
MSH2STK4IntAct23386615 details
MSH2NFKB1MINT25609649 details
MSH2JUNMINT25609649 details
MSH2CEP19BioGRID, IntAct26638075 details
MSH2KSR1IntAct27086506 details
MSH2ANGMINT28777577 details
MSH2RRP1BIntAct20926688 details
MSH2CDK8BioGRID, IntAct29568061 details
MSH2H3C1BioGRID, IntAct29568061 details
MSH2H3C4IntAct29568061 details
MSH2H3C3IntAct29568061 details
MSH2H3C6IntAct29568061 details
MSH2H3C11IntAct29568061 details
MSH2H3C8IntAct29568061 details
MSH2H3C12IntAct29568061 details
MSH2H3C10IntAct29568061 details
MSH2H3C2IntAct29568061 details
MSH2H3C7IntAct29568061 details
MSH2METTL3BioGRID, UniProt29507755 details
MSH2WTAPBioGRID, UniProt29507755 details
MSH2H2AZ1DIP24463511 details
MSH2ANP32EDIP24463511 details
MSH2PPIBBioGRID, IntAct30021884 details
MSH2TNFSF13BBioGRID, IntAct30833792 details
MSH2ZDHHC5UniProt31402609 details
MSH2SIRT7BioGRID22586326 details
MSH2CDK2BioGRID21319273 details
MSH2SRSF5BioGRID22939629 details
MSH2SART1BioGRID22939629 details
MSH2SRSF11BioGRID22939629 details
MSH2SRSF7BioGRID22939629 details
MSH2IKBioGRID22939629 details
MSH2RBM25BioGRID22939629 details
MSH2SMARCA5BioGRID22939629 details
MSH2SRSF10BioGRID22939629 details
MSH2RPS24BioGRID22939629 details
MSH2TOP2BBioGRID22939629 details
MSH2SEPTIN9BioGRID22939629 details
MSH2RAD21BioGRID22939629 details
MSH2HNRNPDBioGRID22939629 details
MSH2SUPT16HBioGRID22939629 details
MSH2ATP6V1B2BioGRID22863883 details
MSH2CUL2BioGRID22863883 details
MSH2JUPBioGRID22863883 details
MSH2DPYSL3BioGRID22863883 details
MSH2XRCC5BioGRID22863883 details
MSH2NRDCBioGRID22863883 details
MSH2PDE3ABioGRID22863883 details
MSH2SEC23ABioGRID22863883 details
MSH2ST13BioGRID22863883 details
MSH2STAT3BioGRID22863883 details
MSH2SUPT5HBioGRID22863883 details
MSH2RPA3BioGRID24332808 details
MSH2RPA2BioGRID24332808 details
MSH2RPA1BioGRID24332808 26344197 details
MSH2CCDC8BioGRID24711643 details
MSH2ANXA6BioGRID26344197 details
MSH2DNAJC9BioGRID26344197 details
MSH2EIF3BBioGRID26344197 details
MSH2FEN1BioGRID26344197 details
MSH2AARS1BioGRID26344197 details
MSH2CIAPIN1BioGRID26344197 details
MSH2DHX15BioGRID26344197 details
MSH2PFDN4BioGRID26344197 details
MSH2RECQLBioGRID26344197 details
MSH2RPLP0BioGRID26344197 details
MSH2RPS5BioGRID26344197 details
MSH2TRIP13BioGRID26344197 details
MSH2ZW10BioGRID26344197 details
MSH2NMD3BioGRID26344197 details
MSH2SNX27BioGRID26344197 details
MSH2TIPRLBioGRID26344197 details
MSH2TPP2BioGRID26344197 details
MSH2TPT1BioGRID26344197 28846114 details
MSH2NTRK1BioGRID25921289 details
MSH2UBXN8BioGRID26389662 details
MSH2FAF2BioGRID26389662 details
MSH2ZNF746BioGRID25315684 details
MSH2TRIM25BioGRID29117863 details
MSH2TESBioGRID28378594 details
MSH2UHRF1BioGRID28803780 31964471 details
MSH2ZUP1BioGRID29576527 details
MSH2TRIM14BioGRID29053956 details
MSH2SLC25A1BioGRID27684187 details
MSH2EGLN3BioGRID26972000 details
MSH2HIF1ABioGRID27320910 details
MSH2UBE2MBioGRID28581483 details
MSH2EFTUD2BioGRID28515276 details
MSH2AAR2BioGRID28515276 details
MSH2PIH1D1BioGRID28515276 details
MSH2SNAI1BioGRID29331416 details
MSH2WWOXBioGRID30619736 details
MSH2RECQL4BioGRID29229926 details
MSH2ZBTB38BioGRID29490077 details
MSH2VIRMABioGRID29507755 details
MSH2ACTC1BioGRID30890647 details
MSH2NR2C2BioGRID30463901 details
MSH2H4C1BioGRID30804502 details
MSH2CDC25BBioGRID28675297 details
MSH2BIRC3BioGRID30948266 details
MSH2STAU1BioGRID30948266 details
MSH2LMBR1LBioGRID31073040 details
MSH2BRD7BioGRID30940648 details
MSH2TRIM28BioGRID29955894 details
MSH2PLEKHA4BioGRID31091453 details
MSH2SMC3BioGRID31010829 details
MSH2MAD2L2BioGRID30154076 details
MSH2ZNF263BioGRID32051553 details
MSH2BRD4BioGRID31239290 32416067 details
MSH2NUPR1BioGRID32780723 details
MSH2RBM45BioGRID26979993 details
MSH2WDR76BioGRID31353912 details
MSH2POLR1GBioGRID34079125 details
MSH2COILBioGRID34079125 details
MSH2H2BC8BioGRID34079125 details
MSH2PARP1BioGRID34079125 details
MSH2TERF2IPBioGRID34079125 details
MSH2CDCA7LIntAct22078878 details
MSH2KDM4CIntAct22078878 details
MSH2CBX4IntAct22078878 details
MSH2HNRNPH1BioGRID26760575 details