Entity Details

Primary name ITSN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15811
EntryNameITSN1_HUMAN
FullNameIntersectin-1
TaxID9606
Evidenceevidence at protein level
Length1721
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesITSN1

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006887 exocytosis
GO:0006897 endocytosis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007420 brain development
GO:0015031 protein transport
GO:0016032 viral process
GO:0016197 endosomal transport
GO:0030027 lamellipodium
GO:0034613 cellular protein localization
GO:0035556 intracellular signal transduction
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0048013 ephrin receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0055037 recycling endosome
GO:0060090 molecular adaptor activity
GO:0060124 positive regulation of growth hormone secretion
GO:0060999 positive regulation of dendritic spine development
GO:0061024 membrane organization
GO:0070064 proline-rich region binding
GO:0097440 apical dendrite
GO:0098793 presynapse
GO:0098871 postsynaptic actin cytoskeleton
GO:0098978 glutamatergic synapse
GO:0150007 clathrin-dependent synaptic vesicle endocytosis
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:2001288 positive regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Endomembrane system
Endosome
Membrane
Nucleus envelope
Recycling endosome

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000261 EH domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
ITSN1_HUMANEPS15_HUMANBioGRID, HPRD, IntAct, MINT10064583 10922467 22558309 26344197 32203420 details
ITSN1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct, MINT10716926 15824104 18539136 20936779 32203420 details
ITSN1_HUMANWASL_HUMANBioGRID, HPRD, MINT11584276 18539136 details
ITSN1_HUMANCDC42_HUMANBioGRID, HPRD, IntAct11584276 12006984 15824104 details
ITSN1_HUMANLMO4_HUMANBioGRID, HPRD, MINT15231748 details
ITSN1_HUMANDYN1_HUMANBioGRID, HPRD, MINT10373452 15834155 18539136 details
ITSN1_HUMANDYN2_HUMANBioGRID, HPRD, MINT15834155 16696976 21900206 details
ITSN1_HUMANEF1A1_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANKIF5A_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANRM20_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANSNX5_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANSMRC2_HUMANBioGRID, HPRD, IntAct16169070 details
ITSN1_HUMANDISC1_HUMANBioGRID, HPRD, IntAct12812986 22558309 31413325 details
ITSN1_HUMANSNP25_HUMANBioGRID, HPRD, MINT10373452 16874303 details
ITSN1_HUMANITSN1_HUMANBioGRID, MINT16874303 21712076 22558309 details
ITSN1_HUMANSHIP2_HUMANMINT18692052 details
ITSN1_HUMANCBL_HUMANBioGRID, IntAct, MINT16914641 18539136 18654987 21712076 details
ITSN1_HUMANAP2B1_HUMANBioGRID, IntAct18654987 22558309 34079125 details
ITSN1_HUMANASAP2_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANBCAP_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANSF3B4_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANCCNO_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANPFD5_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANWBP11_HUMANBioGRID, IntAct18654987 details
ITSN1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANMK06_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANJIP2_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANPLK1_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANKS6A5_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANSH3G2_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANKITH_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANUBE2K_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANM3K20_HUMANBioGRID, MINT21900206 details
ITSN1_HUMANGPVI_HUMANDIP19940238 details
ITSN1_HUMANADA15_HUMANUniProt25825872 details
ITSN1_HUMANADA12_HUMANUniProt25825872 details
ITSN1_HUMANEP15R_HUMANBioGRID, IntAct22558309 26344197 32203420 details
ITSN1_HUMANAP2A1_HUMANBioGRID, IntAct28484035 32203420 details
ITSN1_HUMANSCAM1_HUMANBioGRID, HPRD10777571 details
ITSN1_HUMANTS101_HUMANBioGRID15256501 details
ITSN1_HUMANSTON2_HUMANBioGRID, HPRD11381094 details
ITSN1_HUMANSNP23_HUMANBioGRID, HPRD10373452 details
ITSN1_HUMANEPN2_HUMANBioGRID22558309 details
ITSN1_HUMANPICAL_HUMANBioGRID22558309 details
ITSN1_HUMANFNBP4_HUMANBioGRID22558309 details
ITSN1_HUMANFOG2_HUMANBioGRID22558309 details
ITSN1_HUMANAGFG1_HUMANBioGRID22558309 details
ITSN1_HUMANRFIP2_HUMANBioGRID22558309 details
ITSN1_HUMANDAB2_HUMANBioGRID22558309 details
ITSN1_HUMANAGFG2_HUMANBioGRID22558309 details
ITSN1_HUMANCLIP2_HUMANBioGRID22558309 details
ITSN1_HUMANGOGA5_HUMANBioGRID22558309 details
ITSN1_HUMANPEPL_HUMANBioGRID22558309 details
ITSN1_HUMANP85A_HUMANBioGRID22558309 details
ITSN1_HUMANLIPA2_HUMANBioGRID22558309 details
ITSN1_HUMANCYH1_HUMANBioGRID22558309 details
ITSN1_HUMANBRE1B_HUMANBioGRID22558309 details
ITSN1_HUMANSPDLY_HUMANBioGRID22558309 details
ITSN1_HUMANCLH1_HUMANBioGRID22558309 details
ITSN1_HUMANKI16B_HUMANBioGRID22558309 details
ITSN1_HUMANARFP2_HUMANBioGRID22558309 details
ITSN1_HUMANDESM_HUMANBioGRID22558309 details
ITSN1_HUMANFNBP1_HUMANBioGRID22558309 details
ITSN1_HUMANGCC1_HUMANBioGRID22558309 details
ITSN1_HUMANHIP1_HUMANBioGRID22558309 details
ITSN1_HUMANMTUS2_HUMANBioGRID22558309 details
ITSN1_HUMANCE85L_HUMANBioGRID22558309 details
ITSN1_HUMANPACN3_HUMANBioGRID22558309 details
ITSN1_HUMANPDC6I_HUMANBioGRID22558309 details
ITSN1_HUMANPREX1_HUMANBioGRID22558309 details
ITSN1_HUMANRABE1_HUMANBioGRID22558309 details
ITSN1_HUMANRAI14_HUMANBioGRID22558309 details
ITSN1_HUMANSCOC_HUMANBioGRID22558309 details
ITSN1_HUMANTRIM8_HUMANBioGRID22558309 details
ITSN1_HUMANP3C2B_HUMANBioGRID22558309 details
ITSN1_HUMANGARE2_HUMANBioGRID22558309 details
ITSN1_HUMANSPY2_HUMANBioGRID22558309 details
ITSN1_HUMANDLGP1_HUMANBioGRID22558309 details
ITSN1_HUMANSYNJ2_HUMANBioGRID22558309 details
ITSN1_HUMANFCSD2_HUMANBioGRID22558309 details
ITSN1_HUMANITSN2_HUMANBioGRID22558309 details
ITSN1_HUMANRAB5A_HUMANBioGRID22558309 details
ITSN1_HUMANARF6_HUMANBioGRID22558309 details
ITSN1_HUMANPDE4D_HUMANBioGRID22558309 details
ITSN1_HUMANKHDR1_HUMANBioGRID22745667 details
ITSN1_HUMANSGIP1_HUMANBioGRID20946875 27237791 details
ITSN1_HUMANITCH_HUMANBioGRID26613292 details
ITSN1_HUMANFCHO1_HUMANBioGRID27237791 details
ITSN1_HUMANFCHO2_HUMANBioGRID27237791 details
ITSN1_HUMANWIPF3_HUMANBioGRID28161632 details
ITSN1_HUMANVLDLR_HUMANBioGRID28484035 details
ITSN1_HUMANDAB1_HUMANBioGRID28484035 details
ITSN1_HUMANTMG4_HUMANBioGRID23873930 details
ITSN1_HUMANDOPO_HUMANMINT16874303 details
ITSN1_HUMANSPF30_HUMANIntAct17353931 details
ITSN1_HUMANRHG31_HUMANBioGRID, HPRD, MINT11744688 18539136 details
ITSN1_HUMANSYNJ1_HUMANBioGRID, HPRD, MINT10373452 18539136 details
ITSN1_HUMANSHAN3_HUMANMINT21653829 details
ITSN1_HUMANEPHB2_HUMANBioGRID, HPRD12389031 details
ITSN1_HUMANSH3K1_HUMANBioGRID19166927 details
ITSN1_HUMANAMPH_HUMANBioGRID21712076 details
ITSN1_HUMANREPS1_HUMANBioGRID20946875 details
ITSN1_HUMANWASP_HUMANBioGRID15824104 18539136 details
ITSN1_HUMANCBLB_HUMANBioGRID18539136 details
ITSN1_HUMANPAK3_HUMANBioGRID15824104 details
ITSN1_HUMANTNR6C_HUMANBioGRID29395067 details
ITSN1_HUMANSMAP2_HUMANBioGRID29395067 details
ITSN1_HUMANRASH_HUMANHPRD12970366 details