Entity Details

Primary name PIK3CA
Entity type gene
Source Source Link

Details

PrimaryID5290
RefseqGeneNG_012113
SymbolPIK3CA
Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Chromosome3
Location3q26.32
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-25
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPK3CA_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001944 vasculature development
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005943 phosphatidylinositol 3-kinase complex, class IA
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0006006 glucose metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0010468 regulation of gene expression
GO:0010592 positive regulation of lamellipodium assembly
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030295 protein kinase activator activity
GO:0030835 negative regulation of actin filament depolymerization
GO:0031295 T cell costimulation
GO:0032008 positive regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035994 response to muscle stretch
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038128 ERBB2 signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0043276 anoikis
GO:0043457 regulation of cellular respiration
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0043542 endothelial cell migration
GO:0043560 insulin receptor substrate binding
GO:0044029 hypomethylation of CpG island
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051897 positive regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0055119 relaxation of cardiac muscle
GO:0060048 cardiac muscle contraction
GO:0060612 adipose tissue development
GO:0071333 cellular response to glucose stimulus
GO:0071464 cellular response to hydrostatic pressure
GO:0086003 cardiac muscle cell contraction
GO:0097009 energy homeostasis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0110053 regulation of actin filament organization
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000653 regulation of genetic imprinting
GO:2000811 negative regulation of anoikis

Diseases

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Interactions

137 interactions

InteractorPartnerSourcesPublicationsLink
PIK3CAIRS1BioGRID, IntAct, MINT12933652 14511371 16150444 16354680 23604317 23643389 27684187 details
PIK3CAPIK3R1BioGRID, DIP, HPRD, IntAct, MINT11526404 15377662 15932879 16043515 16135792 18079394 19117013 19574958 19805105 20018188 20713702 22402981 23643389 24657164 25253337 26475863 26496610 26839216 27684187 28205554 32814053 7929193 7957566 9235916 9565634 details
PIK3CAAMBPBioGRID, IntAct18624398 details
PIK3CAATP5IF1BioGRID, IntAct18624398 details
PIK3CAVARS2BioGRID, IntAct18624398 details
PIK3CADDX5BioGRID, IntAct18624398 details
PIK3CADNAJB6BioGRID, IntAct18624398 details
PIK3CAFTLBioGRID, IntAct18624398 details
PIK3CAITIH1BioGRID, IntAct18624398 details
PIK3CANEDD9BioGRID, IntAct18624398 details
PIK3CARPS20BioGRID, IntAct18624398 details
PIK3CASQSTM1BioGRID, IntAct18624398 27684187 details
PIK3CAUFD1BioGRID, IntAct18624398 details
PIK3CAGRB2BioGRID, IntAct19380743 21706016 28514442 32814053 9565634 details
PIK3CAPIK3R3BioGRID, HPRD, IntAct22402981 25814554 26496610 28514442 9415396 details
PIK3CAAPPL1BioGRID, HPRD, IntAct10490823 25241761 details
PIK3CAFANCCBioGRID, MINT24412244 details
PIK3CAGALNT12BioGRID, MINT24412244 details
PIK3CAHRASBioGRID, HPRD, MINT10783161 14724584 24412244 8665852 9150145 details
PIK3CAMAP2K1BioGRID, MINT24412244 details
PIK3CASFRP4BioGRID, MINT24412244 details
PIK3CAFBP2BioGRID, MINT24412244 details
PIK3CATMOD1BioGRID, MINT24412244 details
PIK3CATNFSF13BioGRID, MINT25640309 details
PIK3CAUMPSBioGRID, MINT25640309 details
PIK3CABEX1BioGRID, MINT25640309 details
PIK3CABEX2BioGRID, MINT25640309 details
PIK3CAIL13RA2BioGRID, MINT25640309 details
PIK3CAIL24BioGRID, MINT25640309 details
PIK3CAPSMC3IPBioGRID, MINT25640309 details
PIK3CATHRSPBioGRID, MINT25640309 details
PIK3CACSF2RBDIP23526884 details
PIK3CAFOSIntAct32814053 details
PIK3CAHTTIntAct32814053 details
PIK3CAATXN3IntAct32814053 details
PIK3CAATXN1IntAct32814053 details
PIK3CAATRBioGRID10608806 details
PIK3CARASGRP3BioGRID15213298 details
PIK3CARASD2BioGRID, HPRD14724584 16757351 details
PIK3CALCKBioGRID, HPRD14583609 8020561 8246987 details
PIK3CAADAP1BioGRID12893243 details
PIK3CADGKZBioGRID12890670 details
PIK3CAKRASBioGRID10783161 34079125 details
PIK3CASGK1BioGRID10357815 details
PIK3CAFASLGBioGRID19807924 details
PIK3CASTAT1BioGRID11438544 details
PIK3CASMAD2BioGRID16806069 details
PIK3CASMAD3BioGRID16806069 details
PIK3CAAKT1BioGRID19117013 21041639 21816939 25793261 details
PIK3CAPDK1BioGRID21041639 details
PIK3CACYTH3BioGRID21041639 details
PIK3CACYTH2BioGRID21041639 details
PIK3CAPDGFRABioGRID7682895 details
PIK3CACSF1RBioGRID9380408 details
PIK3CANEDD4LBioGRID27339899 details
PIK3CAEGFRBioGRID1845983 25754235 28205554 31959764 8561895 details
PIK3CASNX9BioGRID17242350 details
PIK3CAPTPN11BioGRID26839216 9565634 9660791 details
PIK3CARELABioGRID15932879 details
PIK3CAARAFBioGRID28205554 details
PIK3CACCND2BioGRID28205554 details
PIK3CAGLIS2BioGRID28205554 details
PIK3CAMYCBioGRID28205554 details
PIK3CASTK11BioGRID28205554 details
PIK3CAERBB3BioGRID, IntAct11546794 19411071 24189400 details
PIK3CAPIK3R2BioGRID, DIP, IntAct19380743 22402981 23604317 25253337 26496610 27684187 details
PIK3CACBLBioGRID, IntAct11157475 19380743 9119889 details
PIK3CAPLCG1BioGRID, IntAct31585087 8561895 details
PIK3CANOTCH1BioGRID14583609 details
PIK3CAARHGEF1BioGRID12754211 details
PIK3CAGNAQBioGRID, HPRD12704201 details
PIK3CAGSNBioGRID11577104 details
PIK3CAYWHAHBioGRID11969417 details
PIK3CAIRS4BioGRID, HPRD11912194 details
PIK3CAUBTFBioGRID17332342 details
PIK3CAWDR5BioGRID21531708 details
PIK3CATNFRSF1ABioGRID15707590 details
PIK3CACD28BioGRID9915850 details
PIK3CAIRS2BioGRID, HPRD12933652 25879670 9113989 details
PIK3CACD40BioGRID12637493 details
PIK3CAESR1BioGRID11029009 24051437 details
PIK3CAGNB1BioGRID19117013 details
PIK3CAKITBioGRID7691885 details
PIK3CARAC1BioGRID25819133 details
PIK3CAPTTG1BioGRID15845362 details
PIK3CADERL1BioGRID28178653 details
PIK3CANRASBioGRID, HPRD30639242 7820549 8665852 details
PIK3CARAPGEF5BioGRID8561895 details
PIK3CATRAF6BioGRID29729098 details
PIK3CAPDGFRBHPRD8702949 details
PIK3CAPRKCDHPRD11676480 details
PIK3CASH3KBP1HPRD10921882 details
PIK3CAMRASHPRD10803462 details
PIK3CAGABRB1HPRD11606067 details
PIK3CAAPLP2HPRD10490823 details
PIK3CAIL3HPRD9113989 details
PIK3CATICAM1HPRD15940673 details
PIK3CARPS6KB1HPRD11279232 details
PIK3CAGRIN2BHPRD10620012 details
PIK3CAPTK2IntAct22402981 details
PIK3CAPIK3CAIntAct23643389 details
PIK3CAHDAC1BioGRID, IntAct26496610 details
PIK3CADPY30BioGRID, IntAct26496610 details
PIK3CANLGN3BioGRID, IntAct28514442 details
PIK3CAMANSC1BioGRID, IntAct28514442 details
PIK3CASUN2BioGRID, IntAct28514442 details
PIK3CAHAVCR2BioGRID, IntAct28514442 details
PIK3CAFLRT1BioGRID, IntAct28514442 details
PIK3CAEFNB2BioGRID, IntAct26186194 28514442 details
PIK3CADEFA5BioGRID, IntAct28514442 details
PIK3CAIL20RABioGRID, IntAct28514442 details
PIK3CATMEM52BBioGRID, IntAct28514442 details
PIK3CARNF19BBioGRID, IntAct28514442 details
PIK3CAZDHHC1BioGRID, IntAct28514442 details
PIK3CAPCBP1BioGRID, IntAct26186194 28514442 details
PIK3CADLG1DIP25253337 details
PIK3CADDR1MINT22057045 details
PIK3CATP53MINT32606738 details
PIK3CACRKBioGRID19380743 details
PIK3CANTRK1BioGRID25921289 details
PIK3CATSPAN14BioGRID26496610 details
PIK3CAMYO1BBioGRID27684187 details
PIK3CACALM1BioGRID27684187 details
PIK3CACLTCBioGRID27684187 details
PIK3CAMYH10BioGRID27684187 details
PIK3CACTNNB1BioGRID27684187 details
PIK3CAEEF1A1BioGRID27684187 details
PIK3CARPS3BioGRID27684187 details
PIK3CAGNAI3BioGRID27684187 details
PIK3CAMATN2BioGRID27684187 details
PIK3CACNOT3BioGRID27684187 details
PIK3CARPS27BioGRID27684187 details
PIK3CAZDHHC18BioGRID30658672 details
PIK3CAZDHHC23BioGRID30658672 details
PIK3CATXNIPBioGRID31669268 details
PIK3CALAMP1BioGRID34079125 details
PIK3CAVIRMABioGRID29507755 details