Entity Details

Primary name MED1
Entity type gene
Source Source Link

Details

PrimaryID5469
RefseqGeneNG_046996
SymbolMED1
Namemediator complex subunit 1
Chromosome17
Location17q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-03-12
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMED1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0000902 cell morphogenesis
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0002088 lens development in camera-type eye
GO:0002154 thyroid hormone mediated signaling pathway
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003406 retinal pigment epithelium development
GO:0003682 chromatin binding
GO:0003712 transcription coregulator activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006590 thyroid hormone generation
GO:0006606 protein import into nucleus
GO:0006702 androgen biosynthetic process
GO:0007420 brain development
GO:0007595 lactation
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0016592 mediator complex
GO:0016922 nuclear receptor binding
GO:0019216 regulation of lipid metabolic process
GO:0030216 keratinocyte differentiation
GO:0030224 monocyte differentiation
GO:0030331 estrogen receptor binding
GO:0030374 nuclear receptor coactivator activity
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0031100 animal organ regeneration
GO:0031490 chromatin DNA binding
GO:0032993 protein-DNA complex
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035050 embryonic heart tube development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035855 megakaryocyte development
GO:0042789 mRNA transcription by RNA polymerase II
GO:0042809 vitamin D receptor binding
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0045444 fat cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046966 thyroid hormone receptor binding
GO:0048821 erythrocyte development
GO:0048822 enucleate erythrocyte development
GO:0050693 LBD domain binding
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744 mammary gland branching involved in thelarche
GO:0060745 mammary gland branching involved in pregnancy
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0061630 ubiquitin protein ligase activity
GO:0070318 positive regulation of G0 to G1 transition
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071383 cellular response to steroid hormone stimulus
GO:0097067 cellular response to thyroid hormone stimulus
GO:1990841 promoter-specific chromatin binding
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001141 regulation of RNA biosynthetic process

Diseases

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Interactions

157 interactions

InteractorPartnerSourcesPublicationsLink
MED1MED29BioGRID, IntAct14638676 15175163 15989967 20133760 22939629 24981860 26344197 28514442 details
MED1TP53BioGRID, HPRD, MINT11118038 15848166 9444950 details
MED1PPARGBioGRID, HPRD, UniProt10037764 10935544 11027271 11500849 11877444 12037571 15026545 15604093 16554032 17011503 17468099 17704298 19596656 22070604 23178929 30575522 30595551 30651555 9325263 details
MED1RARABioGRID, DIP, HPRD, IntAct, MINT, UniProt10760302 17641689 21478865 25303530 9653119 details
MED1ESR2BioGRID, HPRD, IntAct10770935 11500849 11867769 21182203 details
MED1GJB5BioGRID, IntAct21988832 details
MED1THRABioGRID, HPRD, UniProt10037764 10733574 11117530 16799563 18391015 21868449 8710870 9653119 details
MED1VDRBioGRID, DIP, HPRD, IntAct, UniProt10198638 10235266 10733574 10753860 12403843 12796488 15919092 16434701 17786964 21478865 9653119 details
MED1RXRABioGRID, DIP, HPRD, UniProt10935544 11027271 11438648 15863722 21478865 9653119 details
MED1ESR1BioGRID, HPRD, IntAct, UniProt10760302 10770935 11867769 12738788 15886699 18391015 31527615 9653119 details
MED1MYCBioGRID, IntAct17967894 25303530 details
MED1NR1H3IntAct26120082 details
MED1NR1H2BioGRID, HPRD, IntAct15604093 26120082 details
MED1MED18BioGRID, IntAct, MINT15989967 20133760 22939629 24981860 26344197 28514442 details
MED1MED28BioGRID, IntAct15175163 15989967 20133760 24981860 28514442 details
MED1NR1I3BioGRID, HPRD, IntAct15572376 26186194 28514442 details
MED1SREBF1BioGRID, DIP10235267 16799563 details
MED1GATA1BioGRID, DIP, HPRD11724781 17132730 details
MED1PPARGC1ABioGRID, HPRD14636573 details
MED1NR3C1BioGRID10508170 11266503 28611094 31182584 details
MED1YWHAQBioGRID11266503 details
MED1TGS1BioGRID11912212 details
MED1MED1BioGRID, HPRD12037571 12562779 15989967 20133760 23322298 9444950 details
MED1HNF4ABioGRID, HPRD12089346 12101254 details
MED1ARBioGRID, HPRD12218053 details
MED1GABPABioGRID16574658 details
MED1POU1F1BioGRID16396960 details
MED1GATA2BioGRID16396960 details
MED1KIF1ABioGRID15604093 details
MED1CTDP1BioGRID16239144 details
MED1NCOA6BioGRID21292004 details
MED1EZH2BioGRID17502350 details
MED1PIN1BioGRID16055720 details
MED1AKAP9BioGRID30217970 details
MED1CASKBioGRID30217970 details
MED1RBM5BioGRID30217970 details
MED1RPA2BioGRID30217970 details
MED1TET2BioGRID30404004 details
MED1MAPK3BioGRID18391015 details
MED1RORAHPRD10478845 details
MED1MED19BioGRID, IntAct14576168 14638676 15175163 15989967 20133760 21729782 24981860 26186194 26344197 28514442 details
MED1MED10BioGRID, IntAct10882111 14576168 14638676 15175163 15989967 24882805 24981860 28514442 details
MED1MED9BioGRID, HPRD, IntAct14638676 15175163 20098423 24882805 24981860 27684187 28514442 details
MED1CDK19BioGRID, IntAct15175163 20133760 22939629 23602568 24981860 26186194 28514442 details
MED1MDM2BioGRID, HPRD, MINT15848166 details
MED1KAT2ABioGRID, MINT17967894 18418385 20508642 details
MED1CDK8BioGRID, DIP, IntAct, MINT10024883 10198638 10882111 11867769 15989967 18418385 20098423 23322298 23602568 24981860 26186194 26496610 28514442 29568061 details
MED1MED24BioGRID, DIP, IntAct, UniProt15989967 18391015 20098423 20133760 22939629 24981860 26344197 28514442 9653119 details
MED1PPARAUniProt9653119 details
MED1MED21BioGRID, IntAct, MINT15989967 22939629 24882805 24981860 28514442 details
MED1MED7BioGRID, IntAct, MINT15989967 18391015 24882805 24981860 26186194 28514442 details
MED1MED4BioGRID, IntAct, MINT15989967 20133760 22939629 24882805 24981860 25281560 26344197 28514442 details
MED1MED12BioGRID, DIP, HPRD, IntAct15175163 15989967 20098423 20133760 23322298 23563140 24981860 26344197 26496610 27684187 28514442 details
MED1POLR2FBioGRID, IntAct15989967 24981860 26496610 details
MED1PLK1BioGRID, IntAct27173435 unassigned1312 details
MED1SPAG5BioGRID, IntAct27173435 unassigned1312 details
MED1MED31BioGRID, IntAct, MINT15989967 24981860 28514442 details
MED1MED16BioGRID, DIP, IntAct15989967 17967894 20098423 20133760 22939629 24981860 26344197 28514442 details
MED1MED23BioGRID, DIP, IntAct, MINT15989967 20098423 20133760 25281560 28514442 details
MED1MED13BioGRID, DIP, IntAct15989967 20098423 20133760 23322298 23563140 24981860 26344197 28514442 29568061 details
MED1MED11BioGRID, IntAct15989967 22939629 24981860 28514442 details
MED1MED17BioGRID, DIP, IntAct15989967 17967894 18391015 20098423 20133760 24981860 26344197 28514442 details
MED1MED20BioGRID, IntAct, MINT15989967 20133760 24981860 25281560 26344197 28514442 details
MED1MED15BioGRID, DIP, IntAct14657022 15989967 20098423 20133760 24981860 26344197 28514442 details
MED1MED30BioGRID, IntAct, MINT15989967 18691967 20133760 24981860 28514442 details
MED1MED8BioGRID, HPRD, IntAct12584197 15989967 20133760 22939629 24981860 26344197 28514442 details
MED1MED13LBioGRID, IntAct23322298 24981860 28514442 details
MED1MED27BioGRID, IntAct15989967 20133760 22939629 24981860 26344197 28514442 details
MED1MED22BioGRID, IntAct15989967 20098423 20133760 24981860 28514442 details
MED1POLR2ABioGRID, IntAct15989967 24981860 28514442 details
MED1MED6BioGRID, IntAct15989967 18391015 20133760 22939629 24981860 26344197 28514442 details
MED1MED14BioGRID, DIP, HPRD, IntAct15175163 15989967 20098423 20133760 22939629 24981860 26344197 28514442 9989412 details
MED1CCNCBioGRID, DIP18391015 20098423 20133760 24981860 26186194 28514442 details
MED1BRD4BioGRID, DIP19766566 20098423 31239290 32416067 details
MED1MED25BioGRID, DIP, HPRD, IntAct14657022 14983011 15989967 17641689 20098423 20133760 25792360 28514442 details
MED1POLR2EBioGRID, MINT20133760 24981860 details
MED1ATMBioGRID17478428 details
MED1PARP1BioGRID16204234 details
MED1SUPT3HBioGRID17967894 details
MED1SUPT7LBioGRID17967894 details
MED1CDK9BioGRID20133760 details
MED1ZC3H13BioGRID20133760 details
MED1TRIP4BioGRID20133760 details
MED1STN1BioGRID20133760 details
MED1QKIBioGRID20133760 details
MED1FBXW7BioGRID23322298 25720964 details
MED1AHRBioGRID17392787 details
MED1TBPBioGRID18391015 details
MED1GTF2BBioGRID18391015 details
MED1GTF2F2BioGRID18391015 details
MED1YWHAHHPRD11266503 details
MED1THRBHPRD9325263 details
MED1GATA4HPRD11724781 details
MED1GATA6HPRD11724781 details
MED1BRCA1HPRD15208681 details
MED1GATA3HPRD11724781 details
MED1NR4A1HPRD12082103 details
MED1MED26BioGRID, DIP, IntAct15175163 20098423 21729782 24981860 28514442 details
MED1TRRAPBioGRID, MINT18418385 details
MED1TADA2ABioGRID, MINT20508642 details
MED1THRAP3BioGRID, UniProt9653119 details
MED1POLR2GBioGRID, IntAct24981860 26496610 details
MED1EMC2BioGRID, IntAct26496610 details
MED1PPP4R3ABioGRID, IntAct26496610 details
MED1BIRC5BioGRID, IntAct28514442 details
MED1RPAP2BioGRID, IntAct, MINT24981860 28514442 details
MED1MED12LBioGRID, IntAct24981860 28514442 details
MED1POLR2DBioGRID, IntAct, MINT24981860 28514442 details
MED1TCL1BBioGRID, IntAct26186194 28514442 details
MED1SREBF2DIP16799563 details
MED1NUDCD1MINT29021621 details
MED1TP53BP1BioGRID, UniProt29656893 details
MED1LRRC59BioGRID, IntAct30021884 details
MED1POLR2MBioGRID, MINT24981860 details
MED1ZNF281BioGRID22939629 details
MED1ZNF326BioGRID22939629 details
MED1RALYBioGRID22939629 details
MED1SETD7BioGRID22939629 details
MED1EPAS1BioGRID23275444 details
MED1BAG3BioGRID23824909 details
MED1POLLBioGRID26186194 28514442 details
MED1HNRNPCBioGRID26344197 details
MED1NTRK1BioGRID25921289 details
MED1HEXIM1BioGRID29845934 details
MED1RUNX1BioGRID28533407 details
MED1HERC2BioGRID29511261 details
MED1SOX2BioGRID28794006 details
MED1TNRC6ABioGRID28813667 details
MED1H4C1BioGRID27248496 30804502 details
MED1H2BC3BioGRID27248496 details
MED1ATG16L1BioGRID30196744 details
MED1ACTC1BioGRID30890647 details
MED1XRCC6BioGRID30585729 details
MED1LRRC31BioGRID33005030 details
MED1CITBioGRID31586073 details
MED1POLR2CBioGRID24981860 details
MED1POLR2IBioGRID24981860 details
MED1POLR2BBioGRID24981860 details
MED1POLR2HBioGRID24981860 details
MED1POLR2JBioGRID24981860 details
MED1SCAF4BioGRID24981860 details
MED1RPRD2BioGRID24981860 details
MED1ACAD11BioGRID24981860 details
MED1APOA2BioGRID24981860 details
MED1POLR2LBioGRID24981860 details
MED1GPN1BioGRID24981860 details
MED1CBX3BioGRID34079125 details
MED1NUP50BioGRID34079125 details
MED1TERF2IPBioGRID34079125 details
MED1STC2IntAct23746844 details
MED1ANKRD37IntAct23746844 details
MED1PODXLIntAct23548800 details
MED1TFF1IntAct25303530 details
MED1GREB1IntAct25303530 details
MED1ELAVL1BioGRID19322201 details
MED1VIRMABioGRID29507755 details
MED1HNRNPH1BioGRID26760575 details