Entity Details

Primary name SYK
Entity type gene
Source Source Link

Details

PrimaryID6850
RefseqGeneNG_017046
SymbolSYK
Namespleen associated tyrosine kinase
Chromosome9
Location9q22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-23

Ontological Relatives

UniProt IDsKSYK_HUMAN

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001784 phosphotyrosine residue binding
GO:0001945 lymph vessel development
GO:0002092 positive regulation of receptor internalization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0002283 neutrophil activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002554 serotonin secretion by platelet
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006606 protein import into nucleus
GO:0007159 leukocyte cell-cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007257 obsolete activation of JUN kinase activity
GO:0009887 animal organ morphogenesis
GO:0010543 regulation of platelet activation
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016032 viral process
GO:0016170 interleukin-15 receptor binding
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019370 leukotriene biosynthetic process
GO:0019815 B cell receptor complex
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031623 receptor internalization
GO:0032009 early phagosome
GO:0032481 positive regulation of type I interferon production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032752 positive regulation of interleukin-3 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032928 regulation of superoxide anion generation
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035325 Toll-like receptor binding
GO:0035556 intracellular signal transduction
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038110 interleukin-2-mediated signaling pathway
GO:0038156 interleukin-3-mediated signaling pathway
GO:0042101 T cell receptor complex
GO:0042169 SH2 domain binding
GO:0042742 defense response to bacterium
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043306 positive regulation of mast cell degranulation
GO:0043313 regulation of neutrophil degranulation
GO:0043366 beta selection
GO:0045087 innate immune response
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045780 positive regulation of bone resorption
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048514 blood vessel morphogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050853 B cell receptor signaling pathway
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051712 positive regulation of killing of cells of other organism
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071226 cellular response to molecule of fungal origin
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090237 regulation of arachidonic acid secretion
GO:0090330 regulation of platelet aggregation
GO:0097110 scaffold protein binding
GO:0120162 positive regulation of cold-induced thermogenesis

Diseases

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Interactions

168 interactions

InteractorPartnerSourcesPublicationsLink
SYKCBLBioGRID, HPRD, MINT10540342 10570266 10617633 11042121 11133830 11331248 11742985 12435267 15536084 15556646 15577829 16289966 18273061 27614019 31120930 7721825 8621719 9857068 details
SYKLCKBioGRID, HPRD, MINT15536084 7539035 8621719 8798676 8798764 details
SYKFCER1GBioGRID, HPRD, IntAct, MINT8071371 8810294 9280292 details
SYKPIK3R1BioGRID, HPRD, MINT15536084 16921024 details
SYKFGRBioGRID, HPRD, MINT11672534 15536084 details
SYKPIK3R2BioGRID, HPRD, MINT15536084 details
SYKERBB3BioGRID, MINT16273093 22973453 details
SYKERBB2BioGRID, MINT16273093 22973453 details
SYKEGFRBioGRID, MINT16273093 22973453 details
SYKERBB4BioGRID, MINT16273093 22973453 details
SYKSH3BP2BioGRID, HPRD, MINT11390470 12709437 15345594 20439986 9846481 details
SYKVAV2BioGRID, HPRD, MINT11262396 15345594 details
SYKTYROBPBioGRID, HPRD, IntAct10940905 9490415 9830044 details
SYKFCGR2ABioGRID, HPRD, MINT11141335 7487883 8756631 9268059 9280292 9295288 details
SYKCD3EBioGRID, HPRD, MINT7761456 9698567 details
SYKUSP25BioGRID, IntAct, MINT19909739 21516116 25416956 32296183 details
SYKSTAT3BioGRID, DIP, HPRD, IntAct, MINT10825200 20133729 21516116 25416956 31515488 32296183 details
SYKUBASH3BBioGRID, MINT20585042 22267732 details
SYKFLT3IntAct, MINT24525236 28086240 details
SYKARBioGRID, IntAct24728074 details
SYKGAB1BioGRID, IntAct24728074 details
SYKKITBioGRID, IntAct24728074 details
SYKMETBioGRID, IntAct24728074 details
SYKTENT5ABioGRID, IntAct25814554 details
SYKSH2D2ABioGRID, IntAct25416956 details
SYKTERF1bhf-ucl, BioGRID21044950 details
SYKNLRP3IntAct25605870 details
SYKPYCARDIntAct25605870 details
SYKSYKBioGRID, HPRD, IntAct11356834 16291755 18070606 25605870 8657103 9698567 9820500 9857068 details
SYKPPP1CAIntAct32814053 details
SYKLRP1IntAct32814053 details
SYKHSPA1AIntAct32814053 details
SYKHSPA1BIntAct32814053 details
SYKDYNC1I1IntAct32814053 details
SYKCANXIntAct32814053 details
SYKBLMHIntAct32814053 details
SYKAPLP2IntAct32814053 details
SYKA2MIntAct32814053 details
SYKMICOS10-NBL1IntAct32814053 details
SYKNBL1IntAct32814053 details
SYKCPNE8IntAct32814053 details
SYKCRCT1IntAct32814053 details
SYKTRAF6BioGRID, HPRD, IntAct11418661 23962979 25202827 32814053 details
SYKSHC1HPRD, IntAct10482988 32814053 9096689 9388490 9710204 details
SYKRAC1IntAct32814053 details
SYKAPPBioGRID, IntAct21832049 32814053 details
SYKCD79ABioGRID, HPRD7500027 details
SYKCD79BBioGRID, HPRD12453414 7500027 7538118 details
SYKPTPN6BioGRID, HPRD10072516 10747947 10871605 11356834 details
SYKLYNBioGRID, HPRD11536198 7831290 8621719 9820500 details
SYKCRKLBioGRID, HPRD11313252 details
SYKLATBioGRID, HPRD11368773 9891970 details
SYKSRCBioGRID, HPRD15173175 7513017 9389695 details
SYKVAV1BioGRID, HPRD11262396 11331248 8900182 8986718 details
SYKRPS6KB1BioGRID16640565 details
SYKRPS6KB2BioGRID16640565 details
SYKMS4A2BioGRID, HPRD8071371 details
SYKPAG1BioGRID, HPRD10790433 details
SYKCD72BioGRID9590210 details
SYKTUBA1ABioGRID, HPRD10862713 details
SYKFCRL3BioGRID12051764 details
SYKFYNBioGRID, HPRD9535867 details
SYKCBLBBioGRID, HPRD10022120 12771181 27428901 details
SYKHDAC1BioGRID16288017 details
SYKHDAC3BioGRID16288017 details
SYKHDAC6BioGRID16288017 details
SYKHDAC9BioGRID16288017 details
SYKHDAC2BioGRID16288017 details
SYKHDAC4BioGRID16288017 details
SYKCALM1BioGRID3350007 3472906 details
SYKNEDD4BioGRID19953087 details
SYKLCP2BioGRID, HPRD15388330 22267732 details
SYKRPS10BioGRID15536084 details
SYKSLC4A1BioGRID, HPRD10605028 10942405 16118313 1998697 2065070 details
SYKTRAIPBioGRID19151749 details
SYKMAPTBioGRID18070606 details
SYKFCGR3ABioGRID8189062 details
SYKTRIM15BioGRID25450970 details
SYKRHOUBioGRID26598620 details
SYKHGSBioGRID22706924 details
SYKDPP9BioGRID27614019 details
SYKCOASYBioGRID19763791 details
SYKCD22BioGRID, HPRD, IntAct8627166 8647200 details
SYKITGB2BioGRID, HPRD, IntAct10961871 12885943 details
SYKPOU2AF1HPRD, IntAct16713566 details
SYKBLNKBioGRID, HPRD, MINT10981967 18369315 21482705 21822214 details
SYKMSNMINT12387735 details
SYKPLCG1BioGRID, HPRD, MINT15144186 1689310 7682059 7831290 8657103 8885868 details
SYKCD37IntAct22624718 details
SYKFCGR1ABioGRID, HPRD, IntAct11141335 25241761 details
SYKHCLS1BioGRID, HPRD, IntAct25241761 9104825 details
SYKCTTNBioGRID, HPRD, IntAct25241761 8636079 details
SYKGRB2BioGRID, HPRD10747947 11964172 22267732 details
SYKPTK2BBioGRID, HPRD10747947 details
SYKSLABioGRID, HPRD10449770 details
SYKPRKD1BioGRID, HPRD8885868 details
SYKPTK2BioGRID9169439 9342235 details
SYKPXNBioGRID, HPRD9590268 details
SYKPLCG2BioGRID, HPRD10933389 10981967 12470302 12771181 details
SYKCD19BioGRID, HPRD9120258 details
SYKEPORBioGRID, HPRD9852052 details
SYKSIT1BioGRID, HPRD10209036 details
SYKCSF3RBioGRID, HPRD8197119 details
SYKCD4BioGRID7539035 details
SYKSP1BioGRID16288017 details
SYKTUBG1BioGRID16322234 details
SYKINPP5DBioGRID22267732 details
SYKSEC23BBioGRID22267732 details
SYKNCK1BioGRID22267732 details
SYKGRAP2BioGRID22267732 details
SYKITGB3BioGRID11042121 details
SYKFCER1ABioGRID9103201 details
SYKPIK3CGBioGRID7721825 details
SYKBTKBioGRID, HPRD10427990 11226282 11598012 8629002 8630736 details
SYKTUBBBioGRID9880513 details
SYKITGA4BioGRID22623428 details
SYKTLR3BioGRID23962979 details
SYKTLR4BioGRID, HPRD14699155 23962979 details
SYKTLR9BioGRID23962979 details
SYKTRAF3BioGRID23962979 details
SYKTBK1BioGRID23962979 details
SYKMYD88BioGRID23962979 details
SYKMAP3K7BioGRID23962979 details
SYKTICAM1BioGRID23962979 details
SYKPTPROBioGRID23533167 details
SYKIL17RABioGRID25202827 details
SYKTRAF3IP2BioGRID25202827 details
SYKPEAR1BioGRID22993420 details
SYKMEGF10BioGRID22993420 details
SYKTNFRSF1ABioGRID, HPRD16291755 26212014 details
SYKGRM1BioGRID15173175 details
SYKTAMALINBioGRID15173175 details
SYKFLNABioGRID27614019 details
SYKPIK3AP1BioGRID, HPRD11163197 27909057 details
SYKABCF1BioGRID30770245 details
SYKPRKCAHPRD12881490 details
SYKTUBA4AHPRD8617742 details
SYKSTAT5AHPRD10825200 details
SYKMAP4K1HPRD11514608 details
SYKHNRNPUHPRD7831290 details
SYKGAB2HPRD11895767 details
SYKSH2B2HPRD10872802 details
SYKNFAM1HPRD15143214 details
SYKDBNLHPRD9891087 details
SYKIL15RAHPRD11714793 details
SYKCSF2RBHPRD8666899 details
SYKRASA1HPRD9218456 details
SYKIL2RBHPRD7600304 details
SYKRPS6KA1HPRD9218456 details
SYKMAPK3HPRD9218456 details
SYKLAX1HPRD12359715 details
SYKSTAT1HPRD15467722 details
SYKUBBHPRD11046148 details
SYKDUSP3HPRD12447358 details
SYKJAK1HPRD10825200 details
SYKSNCAHPRD11162638 11744621 12096713 details
SYKSIRPB1BioGRID, IntAct10940905 details
SYKVCAM1BioGRID, IntAct19738201 22623428 details
SYKMALInnateDB22366891 details
SYKPKMIntAct24606918 details
SYKHAVCR2UniProt26492563 details
SYKCASP1IntAct25605870 details
SYKATG16L1BioGRID30196744 details
SYKBRD7BioGRID30940648 details
SYKTP53BioGRID31152661 details
SYKPLEKHA4BioGRID31091453 details
SYKNHLRC2BioGRID30397336 details
SYKINSBioGRID32457219 details