Entity Details

Primary name TWIST1
Entity type gene
Source Source Link

Details

PrimaryID7291
RefseqGeneNG_008114
SymbolTWIST1
Nametwist family bHLH transcription factor 1
Chromosome7
Location7p21.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsTWST1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001764 neuron migration
GO:0001843 neural tube closure
GO:0003180 aortic valve morphogenesis
GO:0003183 mitral valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007517 muscle organ development
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0019221 cytokine-mediated signaling pathway
GO:0019904 protein domain specific binding
GO:0030500 regulation of bone mineralization
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032502 developmental process
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033128 negative regulation of histone phosphorylation
GO:0035067 negative regulation of histone acetylation
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042473 outer ear morphogenesis
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043425 bHLH transcription factor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045668 negative regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060021 roof of mouth development
GO:0060363 cranial suture morphogenesis
GO:0060900 embryonic camera-type eye formation
GO:0061029 eyelid development in camera-type eye
GO:0070888 E-box binding
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2000147 positive regulation of cell motility
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000773 negative regulation of cellular senescence
GO:2000780 negative regulation of double-strand break repair
GO:2000793 cell proliferation involved in heart valve development
GO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation

Diseases

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Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
TWIST1TP53BioGRID, IntAct18504427 22975381 25402006 details
TWIST1KAT2BBioGRID, HPRD, IntAct10025406 18504427 details
TWIST1KMT5ABioGRID, MINT21983900 details
TWIST1KAT5IntAct24525235 details
TWIST1STAT3BioGRID, IntAct23623921 25814554 details
TWIST1TCF4BioGRID, IntAct, MINT19534813 25402006 25609649 28514442 details
TWIST1BCL6BioGRID, IntAct25402006 details
TWIST1YY1BioGRID, IntAct25402006 details
TWIST1NEIL3BioGRID, IntAct25402006 details
TWIST1YY2BioGRID, IntAct25402006 details
TWIST1ZIC3BioGRID, IntAct25402006 details
TWIST1TCF3BioGRID, HPRD, IntAct10749989 11248247 20714342 22354994 details
TWIST1C1QBPIntAct19534813 details
TWIST1ARRDC3IntAct19534813 details
TWIST1CLUIntAct19534813 details
TWIST1HTTIntAct32814053 details
TWIST1EP300BioGRID, HPRD10025406 details
TWIST1RBBP7BioGRID20714342 details
TWIST1MTA2BioGRID20714342 22457607 details
TWIST1CHD4BioGRID20714342 details
TWIST1HOXA5BioGRID, HPRD15545268 details
TWIST1IKBKBBioGRID23375009 details
TWIST1KPNA5BioGRID23375009 details
TWIST1KPNA7BioGRID23375009 details
TWIST1ZRANB1BioGRID29748601 details
TWIST1TRIM28BioGRID27412325 details
TWIST1PTENBioGRID30631154 details
TWIST1TRIB3BioGRID31235507 details
TWIST1USP18BioGRID32368392 details
TWIST1ETS2BioGRID, IntAct18598946 details
TWIST1RABGAP1IntAct20195357 details
TWIST1RELABioGRID, HPRD, MINT12553906 21983900 details
TWIST1TWIST1HPRD, IntAct24525235 9343420 details
TWIST1BRD4BioGRID, IntAct24525235 31311807 details
TWIST1NFKB1DIP25266422 details
TWIST1G3BP2DIP25893917 details
TWIST1SOX2BioGRID21532573 details
TWIST1TWIST2BioGRID20714342 details
TWIST1ELSPBP1BioGRID20714342 details
TWIST1HDAC2BioGRID20714342 22457607 details
TWIST1HDAC3BioGRID21884981 details
TWIST1WDR5BioGRID21884981 details
TWIST1CHD3BioGRID22457607 details
TWIST1BTRCBioGRID23375009 26905590 28346424 details
TWIST1PAQR3BioGRID26905590 details
TWIST1SKP2BioGRID28346424 details
TWIST1USP17L2BioGRID29088851 details
TWIST1HDAC6BioGRID28779345 details
TWIST1TUBG1BioGRID28779345 details
TWIST1VIMBioGRID28779345 details
TWIST1CUL4ABioGRID28779345 details
TWIST1RNF8BioGRID29748601 details
TWIST1HIF1ABioGRID23623921 details
TWIST1RAD23ABioGRID31487504 details
TWIST1USP4BioGRID32549341 details
TWIST1GLI3HPRD12142027 details
TWIST1MYOD1HPRD9343420 details
TWIST1H4-16IntAct, MINT21983900 24525235 details
TWIST1H4C15IntAct, MINT21983900 24525235 details
TWIST1H4C9IntAct, MINT21983900 24525235 details
TWIST1H4C1IntAct, MINT21983900 24525235 details
TWIST1H4C4IntAct, MINT21983900 24525235 details
TWIST1H4C6IntAct, MINT21983900 24525235 details
TWIST1H4C12IntAct, MINT21983900 24525235 details
TWIST1H4C11IntAct, MINT21983900 24525235 details
TWIST1H4C3IntAct, MINT21983900 24525235 details
TWIST1H4C8IntAct, MINT21983900 24525235 details
TWIST1H4C2IntAct, MINT21983900 24525235 details
TWIST1H4C5IntAct, MINT21983900 24525235 details
TWIST1H4C13IntAct, MINT21983900 24525235 details
TWIST1H4C14IntAct, MINT21983900 24525235 details
TWIST1HES6BioGRID, MINT21983900 details
TWIST1PPP2CABioGRID, MINT21983900 details
TWIST1BRAPBioGRID, MINT21983900 details
TWIST1HDAC1I2D22056872 details
TWIST1DNMT3BI2D22056872 details
TWIST1CDK9IntAct24525235 details
TWIST1MAXBioGRID, MINT25609649 details
TWIST1CETN1BioGRID, IntAct28514442 details
TWIST1ESR1I2D22056872 details
TWIST1FOSIntAct24029232 details
TWIST1FOSL1IntAct24029232 details