Entity Details

Primary name C7
Entity type gene
Source Source Link

Details

PrimaryID730
RefseqGeneNG_011692
SymbolC7
Namecomplement C7
Chromosome5
Location5p13.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsCO7_HUMAN

GO terms

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GOName
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0006883 cellular sodium ion homeostasis
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0019835 cytolysis
GO:0030449 regulation of complement activation
GO:0070062 extracellular exosome

Diseases

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Disease IDSourceNameDescription
610102 OMIMComplement component 7 deficiency (C7D)A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
C7C5BioGRID, HPRD, IntAct1387399 26841837 30552328 details
C7CLUBioGRID, HPRD8345200 details
C7PLGBioGRID, HPRD7814888 details
C7NTRK1BioGRID25921289 details