Entity Details

Primary name CFLAR
Entity type gene
Source Source Link

Details

PrimaryID8837
RefseqGeneNG_029005
SymbolCFLAR
NameCASP8 and FADD like apoptosis regulator
Chromosome2
Location2q33.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-05-07
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsCFLAR_HUMAN

GO terms

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GOName
GO:0002020 protease binding
GO:0005123 death receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007519 skeletal muscle tissue development
GO:0008047 enzyme activator activity
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010976 positive regulation of neuron projection development
GO:0014732 skeletal muscle atrophy
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0014866 skeletal myofibril assembly
GO:0016032 viral process
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060544 regulation of necroptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0071456 cellular response to hypoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0072126 positive regulation of glomerular mesangial cell proliferation
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0097342 ripoptosome
GO:1901740 negative regulation of myoblast fusion
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903055 positive regulation of extracellular matrix organization
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:1903944 negative regulation of hepatocyte apoptotic process
GO:2000347 positive regulation of hepatocyte proliferation
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
CFLARCASP8BioGRID, DIP, HPRD, IntAct, MINT11741985 12097160 12215447 12887920 15280356 17047155 17159907 19343040 19416807 19710364 21737329 21737330 22322857 22864571 24438025 26186194 28514442 31046799 9208847 9228018 9289491 9326610 9380701 details
CFLARCASP10BioGRID, HPRD, IntAct12887920 21737330 23541952 25241761 9208847 9228018 9289491 details
CFLARSMAD3BioGRID, IntAct21988832 details
CFLARRAF1BioGRID, HPRD, IntAct10837247 16537561 21988832 details
CFLARSPATS1BioGRID, IntAct21988832 details
CFLARFADDBioGRID, HPRD, IntAct17047155 20829884 21737330 22322857 26972597 27321185 29497034 9208847 9228018 9326610 details
CFLARTRAF1BioGRID, HPRD, IntAct10837247 25416956 32296183 9208847 details
CFLARCASP3BioGRID, HPRD9208847 9326610 details
CFLARCFLARBioGRID29374180 9228018 details
CFLARDEDD2BioGRID, HPRD11741985 11965497 details
CFLARDEDDBioGRID, HPRD11741985 11965497 details
CFLARUSP8BioGRID27321185 31443721 details
CFLARCUL1BioGRID32313199 details
CFLARSKP2BioGRID32313199 details
CFLARSKP1BioGRID32313199 details
CFLARRBX1BioGRID32313199 details
CFLARNFKB1HPRD13679070 details
CFLARUSP15IntAct17353931 details
CFLAREPPK1IntAct17353931 details
CFLARFSCN1IntAct17353931 details
CFLARRPS29IntAct17353931 details
CFLARFBLIntAct17353931 details
CFLARSF3B1IntAct17353931 details
CFLARCDC37IntAct17353931 details
CFLARMIFIntAct17353931 details
CFLARSUN2IntAct17353931 details
CFLARRADILIntAct17353931 details
CFLARHNRNPLIntAct17353931 details
CFLAREIF3FIntAct17353931 details
CFLARTUFMIntAct17353931 details
CFLARMAP2K1MINT17110930 details
CFLARMAP2K4HPRD, MINT17110930 details
CFLARMAP2K7HPRD, MINT17110930 details
CFLARTNFRSF10ABioGRID, IntAct19343040 19427028 23142077 27321185 9325248 details
CFLARRIPK1BioGRID, HPRD, IntAct10837247 11002417 17047155 21737330 26972597 details
CFLARTNFSF10BioGRID, IntAct, MINT19432816 20097879 21459798 21525171 21822306 22266862 23678861 details
CFLARFASBioGRID, IntAct21803845 27321185 9208847 9325248 details
CFLARCBLBBioGRID, MINT22884570 details
CFLARNUDCD3IntAct25036637 details
CFLARPSMD2IntAct25036637 details
CFLARFKBPLIntAct25036637 details
CFLARSTUB1BioGRID, IntAct23256568 25036637 details
CFLARCACYBPIntAct25036637 details
CFLARPTGES3LIntAct25036637 details
CFLARPTGES3L-AARSD1IntAct25036637 details
CFLARAARSD1IntAct25036637 details
CFLARRIPK2BioGRID, HPRD9575181 details
CFLARTRAF2BioGRID, HPRD10837247 32313199 9208847 details
CFLARTNFRSF10BBioGRID, HPRD11193041 11940602 19343040 23142077 32313199 9325248 details
CFLARNOD1BioGRID10329646 details
CFLARTRAF3BioGRID10837247 details
CFLARBCL2L1BioGRID, HPRD9326610 details
CFLARMAP3K14BioGRID11002417 details
CFLARTP53BioGRID18559494 21474069 details
CFLARITCHBioGRID18559494 19090833 19808964 21474069 30736843 31443721 details
CFLARXRCC6BioGRID22322857 details
CFLARATG3BioGRID19838173 details
CFLARDAXXBioGRID14637155 details
CFLARFASLGBioGRID21803845 details
CFLARHSP90AA1BioGRID23256568 details
CFLARGSNBioGRID25246592 details
CFLARTICAM1BioGRID21737330 details
CFLARDTX1BioGRID29374180 details
CFLARLAMP1BioGRID29374180 details
CFLARMAP3K5BioGRID29227477 details
CFLARRNF31BioGRID30361438 details
CFLARPRMT5BioGRID30736843 details
CFLARPRMT1BioGRID30736843 details
CFLARGMEB1BioGRID31046799 details
CFLARUSP40BioGRID31046799 details
CFLARERBB3BioGRID31443721 details
CFLARSTAMBPL1BioGRID31817770 details
CFLARPSEN2HPRD10069390 9219695 9990034 details
CFLARIKBKBHPRD11002417 details
CFLARCASP2HPRD9228018 details
CFLARCASP6HPRD9228018 details
CFLARCASP7HPRD9228018 details
CFLARDOK2BioGRID, IntAct17353931 details
CFLARSF3B3BioGRID, IntAct17353931 details
CFLARCD247MINT24502978 details
CFLARPLIN5BioGRID, IntAct26186194 28514442 details
CFLARMYCIntAct22266862 details
CFLARIRF4IntAct23541952 details