Entity Details

Primary name UN45B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWX7
EntryNameUN45B_HUMAN
FullNameProtein unc-45 homolog B
TaxID9606
Evidenceevidence at protein level
Length931
SequenceStatuscomplete
DateCreated2006-09-19
DateModified2021-06-02

Ontological Relatives

GenesUNC45B

GO terms

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GOName
GO:0002088 lens development in camera-type eye
GO:0005829 cytosol
GO:0007517 muscle organ development
GO:0030154 cell differentiation
GO:0051879 Hsp90 protein binding
GO:0061077 chaperone-mediated protein folding

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000225 ArmadilloRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR024660 UNC-45/Cro1/She4, central domainDomainDomain

Diseases

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Disease IDSourceNameDescription
616279 OMIMCataract 43 (CTRCT43)An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. The disease is caused by variants affecting the gene represented in this entry.