Entity Details

Primary name RN168_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IYW5
EntryNameRN168_HUMAN
FullNameE3 ubiquitin-protein ligase RNF168
TaxID9606
Evidenceevidence at protein level
Length571
SequenceStatuscomplete
DateCreated2006-07-11
DateModified2021-06-02

Ontological Relatives

GenesRNF168

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
GO:0016567 protein ubiquitination
GO:0031491 nucleosome binding
GO:0032991 protein-containing complex
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035518 histone H2A monoubiquitination
GO:0035861 site of double-strand break
GO:0036297 interstrand cross-link repair
GO:0036351 histone H2A-K13 ubiquitination
GO:0036352 histone H2A-K15 ubiquitination
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0045190 isotype switching
GO:0045739 positive regulation of DNA repair
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0070534 protein K63-linked ubiquitination
GO:0070535 histone H2A K63-linked ubiquitination

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR034725 E3 ubiquitin-protein ligase RNF168FamilyFamily

Diseases

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Disease IDSourceNameDescription
611943 OMIMRiddle syndrome (RIDL)An autosomal recessive disorder characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. The disease is caused by variants affecting the gene represented in this entry.

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
RN168_HUMANRNF11_HUMANBioGRID, HPRD, IntAct, MINT15231748 32814053 details
RN168_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 details
RN168_HUMANUBB_HUMANBioGRID, IntAct16499958 27558965 details
RN168_HUMANUB2G2_HUMANBioGRID, IntAct19690564 details
RN168_HUMANUBE2N_HUMANBioGRID, IntAct19203578 20725033 23255131 24732096 30529286 details
RN168_HUMANH2AX_HUMANBioGRID, IntAct19203578 19500350 27345151 29499138 31533041 32424115 details
RN168_HUMANTRIM8_HUMANBioGRID, IntAct32296183 details
RN168_HUMANHEM1_HUMANBioGRID, IntAct32296183 details
RN168_HUMANJHD2C_HUMANBioGRID, DIP24240613 details
RN168_HUMANH2A3_HUMANDIP26503038 details
RN168_HUMANH10_HUMANDIP26503038 details
RN168_HUMANH12_HUMANBioGRID, DIP26503038 29233925 details
RN168_HUMANDCTN1_HUMANBioGRID, IntAct22939629 32814053 details
RN168_HUMANWFS1_HUMANIntAct32814053 details
RN168_HUMANSYUA_HUMANIntAct32814053 details
RN168_HUMANH2A2C_HUMANBioGRID19203578 21041483 22492721 22980979 24518117 details
RN168_HUMANH2A2A_HUMANBioGRID21041483 28406400 details
RN168_HUMANH2B2E_HUMANBioGRID21041483 24518117 details
RN168_HUMANKDM4A_HUMANBioGRID22373579 details
RN168_HUMANUBC_HUMANBioGRID22266820 22742833 26503038 28240985 28406400 29330428 31699778 details
RN168_HUMANUB2D3_HUMANBioGRID19500350 22373579 24518117 28244869 33022275 details
RN168_HUMANUB2E1_HUMANBioGRID22492721 details
RN168_HUMANKDM1A_HUMANBioGRID24217620 25999347 details
RN168_HUMANRN168_HUMANBioGRID19203578 30529286 details
RN168_HUMANUBP7_HUMANBioGRID25894431 details
RN168_HUMANSUMO2_HUMANBioGRID26675234 details
RN168_HUMANUB2D1_HUMANBioGRID26508657 27462807 31501315 details
RN168_HUMANH2AZ_HUMANBioGRID26508657 28506460 32424115 details
RN168_HUMANH2A1B_HUMANBioGRID27153538 29233925 31376412 31501315 33022275 details
RN168_HUMANSQSTM_HUMANBioGRID27345151 details
RN168_HUMANWBP2_HUMANBioGRID27578003 details
RN168_HUMANPALB2_HUMANBioGRID28240985 details
RN168_HUMANTOP2A_HUMANBioGRID27558965 details
RN168_HUMANH2A1_HUMANBioGRID27462807 details
RN168_HUMANUB2L3_HUMANBioGRID29643511 details
RN168_HUMANUB2D2_HUMANBioGRID29643511 30529286 details
RN168_HUMANPARP1_HUMANBioGRID30037213 details
RN168_HUMANTNAP3_HUMANBioGRID29233925 details
RN168_HUMANRN126_HUMANBioGRID30529286 details
RN168_HUMANH2AY_HUMANBioGRID32424115 details
RN168_HUMANT2FB_HUMANIntAct20195357 details
RN168_HUMANTP53B_HUMANBioGRID, IntAct, UniProt20016603 21552324 22884692 25999347 29499138 29656893 31501315 details
RN168_HUMANH1X_HUMANDIP26503038 details
RN168_HUMANBRCA1_HUMANBioGRID, UniProt29656893 31501315 details
RN168_HUMANHERC2_HUMANBioGRID20023648 details
RN168_HUMANSMCA5_HUMANBioGRID23264744 details
RN168_HUMANBCL10_HUMANBioGRID24732096 details
RN168_HUMANSUMO3_HUMANBioGRID26675234 details
RN168_HUMANFOXM1_HUMANBioGRID27526106 details
RN168_HUMANBRCA2_HUMANBioGRID28240985 details
RN168_HUMANKI67_HUMANBioGRID27558965 details
RN168_HUMANSUMO1_HUMANBioGRID27558965 details
RN168_HUMANZO1_HUMANBioGRID27558965 details
RN168_HUMANPCM1_HUMANBioGRID27558965 details
RN168_HUMANRRP5_HUMANBioGRID27558965 details
RN168_HUMANNUCL_HUMANBioGRID27558965 details
RN168_HUMANHNRPM_HUMANBioGRID27558965 details
RN168_HUMANDDX21_HUMANBioGRID27558965 details
RN168_HUMANRAI14_HUMANBioGRID27558965 details
RN168_HUMANLIMA1_HUMANBioGRID27558965 details
RN168_HUMANDHX9_HUMANBioGRID27558965 details
RN168_HUMANDHX15_HUMANBioGRID27558965 details
RN168_HUMANDREB_HUMANBioGRID27558965 details
RN168_HUMANPABP4_HUMANBioGRID27558965 details
RN168_HUMANUBP10_HUMANBioGRID27558965 details
RN168_HUMANUBP14_HUMANBioGRID29995557 details
RN168_HUMANKMT5A_HUMANBioGRID31760894 details
RN168_HUMANRABX5_HUMANHPRD16499958 details