Entity Details

Primary name DCPS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96C86
EntryNameDCPS_HUMAN
FullNamem7GpppX diphosphatase
TaxID9606
Evidenceevidence at protein level
Length337
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesDCPS

GO terms

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GOName
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0036245 cellular response to menadione
GO:0042802 identical protein binding
GO:0043069 negative regulation of programmed cell death
GO:0043928 exonucleolytic catabolism of deadenylated mRNA
GO:0045292 mRNA cis splicing, via spliceosome
GO:0050072 m7G(5')pppN diphosphatase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR008594 Scavenger mRNA decapping enzyme DcpS/DCS2FamilyFamily
IPR011145 Scavenger mRNA decapping enzyme, N-terminalFamilyHomologous superfamily
IPR019808 Histidine triad, conserved siteSiteConserved site
IPR036265 HIT-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616459 OMIMAl-Raqad syndrome (ARS)A syndrome characterized by delayed psychomotor development, moderate to severe intellectual disability, poor or absent speech, microcephaly, congenital hypotonia, and severe growth delay. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01649 7-methyl-GpppADrugbanksmall molecule
DB01960 7-methyl-7,8-dihydroguanosine-5'-diphosphateDrugbanksmall molecule
DB03593 7-methyl-5'-guanylic acidDrugbanksmall molecule
DB03958 7-methyl-guanosine-5'-triphosphate-5'-guanosineDrugbanksmall molecule
DB07642 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamineDrugbanksmall molecule
DB07643 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamineDrugbanksmall molecule
DB07644 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamineDrugbanksmall molecule