Entity Details

Primary name CDK19_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BWU1
EntryNameCDK19_HUMAN
FullNameCyclin-dependent kinase 19
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated2005-02-01
DateModified2021-06-02

Ontological Relatives

GenesCDK19

GO terms

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GOName
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0016592 mediator complex
GO:0043065 positive regulation of apoptotic process
GO:0050729 positive regulation of inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
618916 OMIMDevelopmental and epileptic encephalopathy 87 (DEE87)A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE87 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.