Entity Details

Primary name S22A4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H015
EntryNameS22A4_HUMAN
FullNameSolute carrier family 22 member 4
TaxID9606
Evidenceevidence at protein level
Length551
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesSLC22A4

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006641 triglyceride metabolic process
GO:0006814 sodium ion transport
GO:0007589 body fluid secretion
GO:0008513 secondary active organic cation transmembrane transporter activity
GO:0009437 carnitine metabolic process
GO:0015171 amino acid transmembrane transporter activity
GO:0015226 carnitine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015491 cation:cation antiporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015879 carnitine transport
GO:0016324 apical plasma membrane
GO:0030165 PDZ domain binding
GO:0042908 xenobiotic transport
GO:0089718 amino acid import across plasma membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR004749 Organic cation transport protein/SVOPFamilyFamily
IPR005828 Major facilitator, sugar transporter-likeFamilyFamily
IPR005829 Sugar transporter, conserved siteSiteConserved site
IPR020846 Major facilitator superfamily domainDomainDomain
IPR036259 MFS transporter superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
180300 OMIMRheumatoid arthritis (RA)An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00122 CholineDrugbanksmall molecule
DB00123 L-LysineDrugbanksmall molecule
DB00125 ArginineDrugbanksmall molecule
DB00127 SpermineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00332 IpratropiumDrugbanksmall molecule
DB00345 Aminohippuric acidSwissprotsmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00536 GuanidineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00583 LevocarnitineDrugbanksmall molecule
DB00594 AmilorideDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB00987 CytarabineDrugbanksmall molecule
DB01035 ProcainamideDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01053 BenzylpenicillinDrugbanksmall molecule
DB01137 LevofloxacinDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01409 TiotropiumDrugbanksmall molecule
DB01917 PutrescineDrugbanksmall molecule
DB03566 SpermidineDrugbanksmall molecule
DB06691 MepyramineDrugbanksmall molecule
DB08837 TetraethylammoniumDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB14006 Choline salicylateDrugbanksmall molecule
DB14754 SolriamfetolDrugbanksmall molecule

Interactions

4 interactions