Entity Details

Primary name PGES2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H7Z7
EntryNamePGES2_HUMAN
FullNameProstaglandin E synthase 2
TaxID9606
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesPTGES2

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0003677 DNA binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006629 lipid metabolic process
GO:0006749 glutathione metabolic process
GO:0015035 protein-disulfide reductase activity
GO:0016021 integral component of membrane
GO:0016829 lyase activity
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0035578 azurophil granule lumen
GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity
GO:0043295 glutathione binding
GO:0043312 neutrophil degranulation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0050220 prostaglandin-E synthase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR002109 GlutaredoxinDomainDomain
IPR004045 Glutathione S-transferase, N-terminalDomainDomain
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR034334 Prostaglandin E synthase 2FamilyFamily
IPR034335 Prostaglandin E synthase 2, C-terminalDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040079 Glutathione Transferase familyFamilyFamily

Diseases

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