Entity Details

Primary name DUOX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NRD8
EntryNameDUOX2_HUMAN
FullNameDual oxidase 2
TaxID9606
Evidenceevidence at protein level
Length1548
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesDUOX2

GO terms

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GOName
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006590 thyroid hormone generation
GO:0006952 defense response
GO:0006979 response to oxidative stress
GO:0009615 response to virus
GO:0009986 cell surface
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016175 superoxide-generating NAD(P)H oxidase activity
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0020037 heme binding
GO:0030054 cell junction
GO:0031252 cell leading edge
GO:0042335 cuticle development
GO:0042446 hormone biosynthetic process
GO:0042554 superoxide anion generation
GO:0042744 hydrogen peroxide catabolic process
GO:0043020 NADPH oxidase complex
GO:0045177 apical part of cell
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051591 response to cAMP
GO:0070062 extracellular exosome
GO:0090303 positive regulation of wound healing
GO:0106293 NADH oxidase H202-forming activity
GO:0106294 NADPH oxidase H202-forming activity
GO:2000147 positive regulation of cell motility

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR010255 Haem peroxidase superfamilyFamilyHomologous superfamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013112 FAD-binding 8DomainDomain
IPR013121 Ferric reductase, NAD binding domainDomainDomain
IPR013130 Ferric reductase transmembrane component-like domainDomainDomain
IPR017927 FAD-binding domain, ferredoxin reductase-typeDomainDomain
IPR017938 Riboflavin synthase-like beta-barrelFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR019791 Haem peroxidase, animal-typeFamilyFamily
IPR034818 Dual oxidase 2FamilyFamily
IPR034821 Dual oxidase, peroxidase domainDomainDomain
IPR037120 Haem peroxidase domain superfamily, animal typeFamilyHomologous superfamily
IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domainFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
607200 OMIMThyroid dyshormonogenesis 6 (TDH6)A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DUOX2_HUMANTXD11_HUMANHPRD, UniProt15561711 details
DUOX2_HUMANDOXA2_HUMANUniProt25761904 details