Entity Details

Primary name TREA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43280
EntryNameTREA_HUMAN
FullNameTrehalase
TaxID9606
Evidenceevidence at protein level
Length583
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesTREH

GO terms

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GOName
GO:0004555 alpha,alpha-trehalase activity
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0009887 animal organ morphogenesis
GO:0031225 anchored component of membrane
GO:0046658 anchored component of plasma membrane
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001661 Glycoside hydrolase, family 37FamilyFamily
IPR008928 Six-hairpin glycosidase superfamilyFamilyHomologous superfamily
IPR012341 Six-hairpin glycosidase-like superfamilyFamilyHomologous superfamily
IPR018232 Glycoside hydrolase, family 37, conserved siteSiteConserved site

Diseases

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Disease IDSourceNameDescription
612119 OMIMTrehalase deficiency (TREHD)An autosomal recessive condition characterized by the inability to digest trehalose, a disaccharide found in mushrooms, products containing baker's yeast, and dried food. Individuals with trehalase deficiency suffer from abdominal pain, increased rectal flatulence, and diarrhea due to osmotic water flow into the colon. The gene represented in this entry is involved in disease pathogenesis.

Interactions

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