Entity Details

Primary name SPOP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43791
EntryNameSPOP_HUMAN
FullNameSpeckle-type POZ protein
TaxID9606
Evidenceevidence at protein level
Length374
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesSPOP

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0030162 regulation of proteolysis
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031625 ubiquitin protein ligase binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR034089 SPOP, C-terminal BACK domainDomainDomain

Diseases

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Disease IDSourceNameDescription
618828 OMIMNabais Sa-de Vries syndrome 1 (NSDVS1)An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development, speech delay, and variable behavioral abnormalities. Affected individuals show congenital microcephaly and dysmorphic facial features, including round face, small palpebral fissures, highly arched eyebrows, and short nose. The disease is caused by variants affecting the gene represented in this entry.
618829 OMIMNabais Sa-de Vries syndrome 2 (NSDVS2)An autosomal dominant disorder characterized by global developmental delay apparent from birth, impaired intellectual development, speech delay, dysmorphic facial features, and additional anomalies including congenital heart defects, sleep disturbances, hypotonia, and variable endocrine abnormalities. The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry.

Interactions

96 interactions

InteractorPartnerSourcesPublicationsLink
SPOP_HUMANZBT16_HUMANBioGRID, HPRD, IntAct16189514 details
SPOP_HUMANDPPA2_HUMANBioGRID, HPRD, IntAct16189514 details
SPOP_HUMANRXRB_HUMANBioGRID, HPRD, IntAct16189514 21988832 31911863 details
SPOP_HUMANDDIT3_HUMANBioGRID, HPRD, IntAct16189514 24990631 details
SPOP_HUMANRTN3_HUMANBioGRID, HPRD, IntAct16189514 details
SPOP_HUMANMYD88_HUMANBioGRID, HPRD, IntAct16189514 21988832 26186194 28514442 31776466 details
SPOP_HUMANGCC1_HUMANBioGRID, MINT21516116 details
SPOP_HUMANDAXX_HUMANBioGRID, IntAct15240113 16524876 21573799 21988832 28805822 30244836 31911863 details
SPOP_HUMANPIAS1_HUMANBioGRID, IntAct21988832 28805822 details
SPOP_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
SPOP_HUMANCUL3_HUMANBioGRID, I2D, IntAct16524876 19256485 19261606 21577200 21988832 22013077 22632832 22911784 25011449 25278611 28216678 29160310 30244836 31559706 details
SPOP_HUMANFADD_HUMANBioGRID, IntAct21988832 30190126 details
SPOP_HUMANSRRM1_HUMANBioGRID, IntAct21988832 28805822 29996942 31911863 details
SPOP_HUMANNCOA3_HUMANBioGRID, I2D21577200 23559371 28805822 29996942 details
SPOP_HUMANPTEN_HUMANBioGRID, IntAct24656772 27622336 32297747 details
SPOP_HUMANARI1_HUMANBioGRID, IntAct28514442 30244836 details
SPOP_HUMANTRAF1_HUMANBioGRID, HPRD11279055 details
SPOP_HUMANTRAF6_HUMANBioGRID11279055 details
SPOP_HUMANANDR_HUMANBioGRID19762545 24508459 25274033 30244836 33158056 details
SPOP_HUMANSPOP_HUMANBioGRID15240113 22632832 25278611 27220849 30244836 31559706 32905556 details
SPOP_HUMANPI42B_HUMANBioGRID18218622 details
SPOP_HUMANUB2E3_HUMANBioGRID19256485 details
SPOP_HUMANGLI2_HUMANBioGRID25204354 28032859 28805822 details
SPOP_HUMANDEK_HUMANBioGRID25278611 28805822 29996942 31771591 details
SPOP_HUMANBRMS1_HUMANBioGRID22085717 details
SPOP_HUMANERG_HUMANBioGRID26344095 26344096 details
SPOP_HUMANERF_HUMANBioGRID26344095 details
SPOP_HUMANGLI3_HUMANBioGRID26475525 27220849 28805822 29996942 31911863 details
SPOP_HUMANUB2D1_HUMANBioGRID26344096 details
SPOP_HUMANUB2D2_HUMANBioGRID26344096 details
SPOP_HUMANNANOG_HUMANBioGRID26687479 30595535 30595538 31624231 details
SPOP_HUMANEGLN2_HUMANBioGRID28089830 details
SPOP_HUMANBRD4_HUMANBioGRID28805820 28805822 31559706 details
SPOP_HUMANBRD3_HUMANBioGRID28805820 28805821 28805822 31026449 details
SPOP_HUMANBRD2_HUMANBioGRID28805820 28805822 29996942 31776466 details
SPOP_HUMANCHD3_HUMANBioGRID28805822 29996942 details
SPOP_HUMANCAPR1_HUMANBioGRID28805822 29395067 29996942 31771591 31776466 31911863 32905556 details
SPOP_HUMANPKCB1_HUMANBioGRID28805822 29996942 31776466 details
SPOP_HUMANSETD2_HUMANBioGRID28805822 31911863 details
SPOP_HUMANH2AY_HUMANBioGRID, HPRD12183056 28805822 details
SPOP_HUMANINF2_HUMANBioGRID28805822 29996942 31776466 31911863 details
SPOP_HUMANUBC9_HUMANBioGRID28805822 29996942 details
SPOP_HUMANRANB9_HUMANBioGRID28805822 details
SPOP_HUMANZCH12_HUMANBioGRID28805822 details
SPOP_HUMANNUDC3_HUMANBioGRID28805822 details
SPOP_HUMANGCC2_HUMANBioGRID28805822 details
SPOP_HUMANPIAS3_HUMANBioGRID28805822 29996942 details
SPOP_HUMANRFOX2_HUMANBioGRID28805822 details
SPOP_HUMANCBX4_HUMANBioGRID28805822 details
SPOP_HUMANAMOL2_HUMANBioGRID28805822 details
SPOP_HUMANFAF1_HUMANBioGRID28805822 details
SPOP_HUMANSUH_HUMANBioGRID28805822 details
SPOP_HUMANCAF1A_HUMANBioGRID28805822 details
SPOP_HUMANTCOF_HUMANBioGRID28805822 details
SPOP_HUMANSUMO1_HUMANBioGRID28805822 details
SPOP_HUMANRPRD2_HUMANBioGRID28805822 details
SPOP_HUMANMRE11_HUMANBioGRID28805822 details
SPOP_HUMANLRCH4_HUMANBioGRID28805822 details
SPOP_HUMANIMA6_HUMANBioGRID28805822 details
SPOP_HUMANHMCS1_HUMANBioGRID28805822 details
SPOP_HUMANGMEB1_HUMANBioGRID28805822 details
SPOP_HUMANDHX15_HUMANBioGRID28805822 details
SPOP_HUMANCTSL2_HUMANBioGRID28805822 details
SPOP_HUMANCACL1_HUMANBioGRID28805822 details
SPOP_HUMANCDC20_HUMANBioGRID27780719 29160310 details
SPOP_HUMAN1433G_HUMANBioGRID29160310 details
SPOP_HUMANCDK4_HUMANBioGRID29160310 details
SPOP_HUMANATF2_HUMANBioGRID29996942 details
SPOP_HUMANAEN_HUMANBioGRID29996942 details
SPOP_HUMANTOPRS_HUMANBioGRID29996942 details
SPOP_HUMANP66A_HUMANBioGRID29996942 details
SPOP_HUMANCREB5_HUMANBioGRID29996942 details
SPOP_HUMANCCNE1_HUMANBioGRID30237511 31636116 details
SPOP_HUMANPDX1_HUMANBioGRID, HPRD15121856 30449689 details
SPOP_HUMANIRF1_HUMANBioGRID31776466 details
SPOP_HUMANILF3_HUMANBioGRID31772275 details
SPOP_HUMANAURKA_HUMANBioGRID33158056 details
SPOP_HUMANSIR2_HUMANBioGRID, IntAct17353931 28073696 details
SPOP_HUMANDUS7_HUMANBioGRID, IntAct24656772 27622336 details
SPOP_HUMANBMI1_HUMANBioGRID15897469 details
SPOP_HUMANESR1_HUMANBioGRID18414007 25766326 details
SPOP_HUMANATM_HUMANBioGRID24451148 details
SPOP_HUMANPRGR_HUMANBioGRID26693071 details
SPOP_HUMANHDAC6_HUMANBioGRID28599312 details
SPOP_HUMANMYC_HUMANBioGRID28414305 30002443 details
SPOP_HUMANSENP7_HUMANBioGRID29777712 details
SPOP_HUMANPD1L1_HUMANBioGRID29160310 32941674 details
SPOP_HUMANFZR1_HUMANBioGRID29160310 details
SPOP_HUMANFAS_HUMANBioGRID30955223 details
SPOP_HUMANG3BP1_HUMANBioGRID31771591 32905556 details
SPOP_HUMANMK01_HUMANBioGRID31772275 details
SPOP_HUMANMK03_HUMANBioGRID31772275 details
SPOP_HUMANLATS1_HUMANBioGRID32460168 details
SPOP_HUMANSNAI1_HUMANBioGRID32736710 details
SPOP_HUMANDHX9_HUMANBioGRID32905556 details
SPOP_HUMANHCST_HUMANHPRD10426994 12426564 12426565 12740575 details