Entity Details

Primary name CATA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04040
EntryNameCATA_HUMAN
FullNameCatalase
TaxID9606
Evidenceevidence at protein level
Length527
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesCAT

GO terms

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GOName
GO:0000268 peroxisome targeting sequence binding
GO:0000302 response to reactive oxygen species
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0004046 aminoacylase activity
GO:0004096 catalase activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005764 lysosome
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006641 triglyceride metabolic process
GO:0007568 aging
GO:0008104 protein localization
GO:0008203 cholesterol metabolic process
GO:0009060 aerobic respiration
GO:0009642 response to light intensity
GO:0009650 UV protection
GO:0010193 response to ozone
GO:0010288 response to lead ion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014854 response to inactivity
GO:0016020 membrane
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019899 enzyme binding
GO:0020027 hemoglobin metabolic process
GO:0020037 heme binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032355 response to estradiol
GO:0032868 response to insulin
GO:0032991 protein-containing complex
GO:0033189 response to vitamin A
GO:0033197 response to vitamin E
GO:0033591 response to L-ascorbic acid
GO:0034599 cellular response to oxidative stress
GO:0034774 secretory granule lumen
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0046872 metal ion binding
GO:0050661 NADP binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051781 positive regulation of cell division
GO:0055093 response to hyperoxia
GO:0070062 extracellular exosome
GO:0070542 response to fatty acid
GO:0071363 cellular response to growth factor stimulus
GO:0080184 response to phenylpropanoid
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Peroxisome

Domains

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DomainNameCategoryType
IPR002226 Catalase haem-binding siteSiteBinding site
IPR010582 Catalase immune-responsive domainDomainDomain
IPR011614 Catalase core domainDomainDomain
IPR018028 Catalase, mono-functional, haem-containingFamilyFamily
IPR020835 Catalase superfamilyFamilyHomologous superfamily
IPR024708 Catalase active siteSiteActive site
IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3FamilyFamily
IPR040333 Catalase, clade 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
614097 OMIMAcatalasemia (ACATLAS)A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01213 FomepizoleDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09116 Calcium carbimideDrugbanksmall molecule
DB11091 Hydrogen peroxideSwissprotsmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule