Entity Details

Primary name CAN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07384
EntryNameCAN1_HUMAN
FullNameCalpain-1 catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length714
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesCAPN1

GO terms

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GOName
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0016020 membrane
GO:0016241 regulation of macroautophagy
GO:0022617 extracellular matrix disassembly
GO:0032801 receptor catabolic process
GO:0043312 neutrophil degranulation
GO:0050790 regulation of catalytic activity
GO:0060056 mammary gland involution
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0097264 self proteolysis
GO:1904813 ficolin-1-rich granule lumen
GO:2000310 regulation of NMDA receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029643 Calpain-1FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616907 OMIMSpastic paraplegia 76, autosomal recessive (SPG76)A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04276 4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azaniumDrugbanksmall molecule
DB04653 N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamideDrugbanksmall molecule
DB07627 (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDEDrugbanksmall molecule

Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
CAN1_HUMANRCAN1_HUMANIntAct15935327 details
CAN1_HUMANPTN1_HUMANMINT19712109 9407132 details
CAN1_HUMANCLC4G_HUMANBioGRID, IntAct18624398 details
CAN1_HUMANSTAT3_HUMANBioGRID, IntAct21988832 details
CAN1_HUMANEZRI_HUMANMINT22805611 details
CAN1_HUMANTIRAP_HUMANInnateDB23023391 details
CAN1_HUMANVIME_HUMANBioGRID, HPRD, IntAct12358155 28514442 details
CAN1_HUMANKCY_HUMANIntAct32814053 details
CAN1_HUMANBAD_HUMANIntAct32814053 details
CAN1_HUMANOPTN_HUMANIntAct32814053 details
CAN1_HUMANA4_HUMANIntAct32814053 details
CAN1_HUMANPSN2_HUMANBioGRID, HPRD10677567 9852298 details
CAN1_HUMANIKBA_HUMANBioGRID, HPRD10521480 details
CAN1_HUMANFANCA_HUMANBioGRID20518497 details
CAN1_HUMANFANCG_HUMANBioGRID20518497 details
CAN1_HUMANRAD21_HUMANBioGRID21876002 22145905 details
CAN1_HUMANANM5_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANSH3BG_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANFHL2_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANTINAL_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCREG1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANECHM_HUMANBioGRID, HPRD12358155 22863883 details
CAN1_HUMANNDUB7_HUMANBioGRID12358155 details
CAN1_HUMANSLIT3_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANALAT1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCATC_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANPTGDS_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANTLE5_HUMANBioGRID12358155 details
CAN1_HUMANNF2L1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANACTC_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANMYPC3_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANACTN2_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANDESM_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANCO1A1_HUMANBioGRID, HPRD12358155 details
CAN1_HUMANSPTN1_HUMANBioGRID, HPRD8993318 details
CAN1_HUMANHNRPD_HUMANBioGRID15231747 details
CAN1_HUMANATG5_HUMANBioGRID16998475 details
CAN1_HUMANATX3_HUMANBioGRID28334907 details
CAN1_HUMANTAU_HUMANBioGRID22535953 details
CAN1_HUMANS22A1_HUMANBioGRID31318583 details
CAN1_HUMANUFSP2_HUMANHPRD12358155 details
CAN1_HUMANLTOR1_HUMANHPRD12358155 details
CAN1_HUMANCO3A1_HUMANHPRD12358155 details
CAN1_HUMANSYNE1_HUMANHPRD12358155 details
CAN1_HUMANCPNS1_HUMANBioGRID, HPRD, IntAct, MINT12591934 19712109 26496610 28514442 details
CAN1_HUMANNMDE2_HUMANBioGRID, HPRD, IntAct10846184 25241761 details
CAN1_HUMANPAR1_HUMANBioGRID, HPRD, IntAct10978167 25241761 details
CAN1_HUMANICAL_HUMANBioGRID, HPRD, IntAct12684003 20679491 26496610 28514442 details
CAN1_HUMANKNG1_HUMANBioGRID, HPRD, IntAct26186194 28514442 3038169 8253784 details
CAN1_HUMANFANCC_HUMANBioGRID20518497 details
CAN1_HUMANPALB2_HUMANBioGRID20518497 details
CAN1_HUMANGAS2_HUMANBioGRID20679491 details
CAN1_HUMANHIF1A_HUMANBioGRID19458911 details
CAN1_HUMANITA4_HUMANBioGRID22623428 details
CAN1_HUMANP53_HUMANBioGRID, HPRD12432277 23443559 details
CAN1_HUMANNMT1_HUMANBioGRID16530191 details
CAN1_HUMANFXL12_HUMANBioGRID26124079 details
CAN1_HUMANAKT1_HUMANBioGRID24462114 details
CAN1_HUMANIL1A_HUMANHPRD7499244 details
CAN1_HUMANITB3_HUMANHPRD7592818 details
CAN1_HUMANB2CL1_HUMANHPRD12000759 details
CAN1_HUMANINP4A_HUMANHPRD9110986 details
CAN1_HUMANBID_HUMANHPRD12000759 details
CAN1_HUMANCD5R1_HUMANHPRD10830966 details
CAN1_HUMANCASPE_HUMANHPRD12200134 details
CAN1_HUMANGBG12_HUMANHPRD7493986 details
CAN1_HUMANSPTB2_HUMANHPRD9989581 details
CAN1_HUMANCBL_HUMANHPRD8695851 details
CAN1_HUMANPAR2_HUMANHPRD10978167 details
CAN1_HUMANARF6_HUMANHPRD16737952 details