Entity Details

Primary name IRGM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA1A4Y4
EntryNameIRGM_HUMAN
FullNameImmunity-related GTPase family M protein
TaxID9606
Evidenceevidence at protein level
Length181
SequenceStatuscomplete
DateCreated2008-03-18
DateModified2021-06-02

Ontological Relatives

GenesIRGM

GO terms

Show/Hide Table
GOName
GO:0000045 autophagosome assembly
GO:0000139 Golgi membrane
GO:0000421 autophagosome membrane
GO:0001891 phagocytic cup
GO:0001934 positive regulation of protein phosphorylation
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0010508 positive regulation of autophagy
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0030670 phagocytic vesicle membrane
GO:0031648 protein destabilization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035458 cellular response to interferon-beta
GO:0042742 defense response to bacterium
GO:0042995 cell projection
GO:0043254 regulation of protein-containing complex assembly
GO:0043539 protein serine/threonine kinase activator activity
GO:0045087 innate immune response
GO:0050700 CARD domain binding
GO:0050821 protein stabilization
GO:0050829 defense response to Gram-negative bacterium
GO:0051434 BH3 domain binding
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0061635 regulation of protein complex stability
GO:0061739 protein lipidation involved in autophagosome assembly
GO:0061762 CAMKK-AMPK signaling cascade
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0075044 positive regulation by symbiont of host autophagy
GO:0098586 cellular response to virus
GO:1901098 positive regulation of autophagosome maturation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Cytoplasmic vesicle
Golgi apparatus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR007743 Immunity-related GTPases-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030385 IRG-type guanine nucleotide-binding (G) domainDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
612278 OMIMInflammatory bowel disease 19 (IBD19)A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Disease susceptibility is associated with variants affecting the gene represented in this entry.