Entity Details

Primary name CD36_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16671
EntryNameCD36_HUMAN
FullNamePlatelet glycoprotein 4
TaxID9606
Evidenceevidence at protein level
Length472
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesCD36

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001540 amyloid-beta binding
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002224 toll-like receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002576 platelet degranulation
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005044 scavenger receptor activity
GO:0005324 long-chain fatty acid transporter activity
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007263 nitric oxide mediated signal transduction
GO:0007596 blood coagulation
GO:0008035 high-density lipoprotein particle binding
GO:0008289 lipid binding
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010886 positive regulation of cholesterol storage
GO:0010942 positive regulation of cell death
GO:0015636 short-chain fatty acid transmembrane transporter activity
GO:0015909 long-chain fatty acid transport
GO:0015911 long-chain fatty acid import across plasma membrane
GO:0015912 short-chain fatty acid transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019222 regulation of metabolic process
GO:0019915 lipid storage
GO:0019934 cGMP-mediated signaling
GO:0030169 low-density lipoprotein particle binding
GO:0030194 positive regulation of blood coagulation
GO:0030299 intestinal cholesterol absorption
GO:0030301 cholesterol transport
GO:0030666 endocytic vesicle membrane
GO:0031092 platelet alpha granule membrane
GO:0031526 brush border membrane
GO:0031623 receptor internalization
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033993 response to lipid
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034197 triglyceride transport
GO:0034381 plasma lipoprotein particle clearance
GO:0034383 low-density lipoprotein particle clearance
GO:0035325 Toll-like receptor binding
GO:0035579 specific granule membrane
GO:0035634 response to stilbenoid
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042308 negative regulation of protein import into nucleus
GO:0042953 lipoprotein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043254 regulation of protein-containing complex assembly
GO:0043277 apoptotic cell clearance
GO:0043312 neutrophil degranulation
GO:0044539 long-chain fatty acid import into cell
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045335 phagocytic vesicle
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050431 transforming growth factor beta binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050830 defense response to Gram-positive bacterium
GO:0050892 intestinal absorption
GO:0050909 sensory perception of taste
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0060100 positive regulation of phagocytosis, engulfment
GO:0060907 positive regulation of macrophage cytokine production
GO:0070053 thrombospondin receptor activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070508 cholesterol import
GO:0070542 response to fatty acid
GO:0070543 response to linoleic acid
GO:0070892 lipoteichoic acid immune receptor activity
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071447 cellular response to hydroperoxide
GO:0071726 cellular response to diacyl bacterial lipopeptide
GO:0071813 lipoprotein particle binding
GO:0071944 cell periphery
GO:0097009 energy homeostasis
GO:0098900 regulation of action potential
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:0150024 oxidised low-density lipoprotein particle clearance
GO:0150025 oxidised low-density lipoprotein particle receptor activity
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901480 oleate transmembrane transporter activity
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904646 cellular response to amyloid-beta
GO:1990000 amyloid fibril formation
GO:1990379 lipid transport across blood-brain barrier
GO:2000121 regulation of removal of superoxide radicals
GO:2000334 positive regulation of blood microparticle formation

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Cell membrane
Golgi apparatus
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR002159 CD36 familyFamilyFamily
IPR005428 CD36/scavenger receptor class B member 1FamilyFamily
IPR033076 CD36FamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
608404 OMIMPlatelet glycoprotein IV deficiency (PG4D)A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. The disease is caused by variants affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk.
610938 OMIMCoronary heart disease 7 (CHDS7)A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Disease susceptibility is associated with variants affecting the gene represented in this entry.