Entity Details

Primary name CADH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19022
EntryNameCADH2_HUMAN
FullNameCadherin-2
TaxID9606
Evidenceevidence at protein level
Length906
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesCDH2

GO terms

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GOName
GO:0003323 type B pancreatic cell development
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0007043 cell-cell junction assembly
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007416 synapse assembly
GO:0007420 brain development
GO:0008013 beta-catenin binding
GO:0009986 cell surface
GO:0010001 glial cell differentiation
GO:0014032 neural crest cell development
GO:0014069 postsynaptic density
GO:0014704 intercalated disc
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0016342 catenin complex
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0021987 cerebral cortex development
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0034332 adherens junction organization
GO:0035995 detection of muscle stretch
GO:0042383 sarcolemma
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043410 positive regulation of MAPK cascade
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0044853 plasma membrane raft
GO:0045177 apical part of cell
GO:0045294 alpha-catenin binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0048514 blood vessel morphogenesis
GO:0048854 brain morphogenesis
GO:0048872 homeostasis of number of cells
GO:0050770 regulation of axonogenesis
GO:0051146 striated muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060019 radial glial cell differentiation
GO:0060563 neuroepithelial cell differentiation
GO:0062023 collagen-containing extracellular matrix
GO:0070445 regulation of oligodendrocyte progenitor proliferation
GO:0072659 protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090497 mesenchymal cell migration
GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly
GO:0097150 neuronal stem cell population maintenance
GO:0098609 cell-cell adhesion
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0099059 integral component of presynaptic active zone membrane
GO:0099060 integral component of postsynaptic specialization membrane
GO:1902897 regulation of postsynaptic density protein 95 clustering
GO:2000809 positive regulation of synaptic vesicle clustering

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell surface

Domains

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DomainNameCategoryType
IPR000233 Cadherin, cytoplasmic domainDomainDomain
IPR002126 Cadherin-likeDomainDomain
IPR014868 Cadherin prodomainDomainDomain
IPR015919 Cadherin-like superfamilyFamilyHomologous superfamily
IPR020894 Cadherin conserved siteSiteConserved site
IPR027397 Catenin binding domain superfamilyFamilyHomologous superfamily
IPR030051 N-cadherinFamilyFamily
IPR039808 CadherinFamilyFamily

Diseases

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Disease IDSourceNameDescription
618929 OMIMAgenesis of corpus callosum, cardiac, ocular, and genital syndrome (ACOGS)An autosomal dominant, syndromic neurodevelopmental disorder characterized by global developmental delay and/or intellectual disability, corpus callosum agenesis or hypoplasia, mirror movements, dysmorphic features, and ocular, cardiac, and genital anomalies. The disease is caused by variants affecting the gene represented in this entry.
618920 OMIMArrhythmogenic right ventricular dysplasia, familial, 14 (ARVD14)A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
CADH2_HUMANPTPRC_HUMANIntAct19167335 details
CADH2_HUMANPTPRK_HUMANIntAct19167335 details
CADH2_HUMANPTPRG_HUMANIntAct19167335 details
CADH2_HUMANPTPRB_HUMANIntAct19167335 details
CADH2_HUMANPTPRJ_HUMANIntAct19167335 details
CADH2_HUMANPTPRO_HUMANIntAct19167335 details
CADH2_HUMANPTPRR_HUMANIntAct19167335 details
CADH2_HUMANPTN7_HUMANIntAct19167335 details
CADH2_HUMANPTN6_HUMANIntAct19167335 details
CADH2_HUMANPTN12_HUMANIntAct19167335 details
CADH2_HUMANPTN22_HUMANIntAct19167335 details
CADH2_HUMANEXOC5_HUMANBioGRID, IntAct21988832 details
CADH2_HUMANFA20C_HUMANIntAct22582013 details
CADH2_HUMANGNA12_HUMANBioGRID, HPRD11136230 details
CADH2_HUMANGNA13_HUMANBioGRID, HPRD11136230 details
CADH2_HUMANPKP4_HUMANBioGRID12615965 details
CADH2_HUMANUBC_HUMANBioGRID23314748 details
CADH2_HUMANCBP_HUMANBioGRID, HPRD13678586 19114997 details
CADH2_HUMANCTNB1_HUMANbhf-ucl, BioGRID, DIP, HPRD, IntAct, MINT11835406 12077367 12151522 12604612 14625392 17057644 17098867 17510365 17679699 18302981 18948590 21357690 25143387 34079125 details
CADH2_HUMANKAP0_HUMANIntAct20195357 details
CADH2_HUMANCTND1_HUMANBioGRID, IntAct12604612 14625392 20371349 21357690 details
CADH2_HUMANPLAK_HUMANbhf-ucl, BioGRID, DIP, HPRD12604612 14625392 1639850 17098867 22939629 7650039 8074697 details
CADH2_HUMANACTS_HUMANBioGRID12438242 details
CADH2_HUMANCTNA1_HUMANBioGRID, HPRD12604612 14625392 22939629 details
CADH2_HUMANCAD11_HUMANBioGRID, HPRD14625392 details
CADH2_HUMANRAB8B_HUMANBioGRID12639940 details
CADH2_HUMANBOC_HUMANBioGRID, HPRD12634428 details
CADH2_HUMANCDON_HUMANBioGRID, HPRD12634428 details
CADH2_HUMANCADH4_HUMANBioGRID, HPRD10662782 details
CADH2_HUMANFBSP1_HUMANBioGRID25143387 details
CADH2_HUMANSKP1_HUMANBioGRID25143387 details
CADH2_HUMANCCNA2_HUMANBioGRID22152476 details
CADH2_HUMANDDR1_HUMANBioGRID20432435 details
CADH2_HUMANDDR2_HUMANBioGRID20432435 details
CADH2_HUMANEGFR_HUMANBioGRID19033391 details
CADH2_HUMANERBB2_HUMANBioGRID19033391 details
CADH2_HUMANPSN1_HUMANBioGRID20696212 details
CADH2_HUMANNHRF1_HUMANBioGRID20736378 details
CADH2_HUMANFGFR1_HUMANBioGRID17005551 18302981 details
CADH2_HUMANFGFR4_HUMANHPRD9168198 details
CADH2_HUMANGRIK2_HUMANHPRD12151522 details
CADH2_HUMANP85A_HUMANHPRD15192701 details
CADH2_HUMANPTN1_HUMANHPRD11106648 12377785 details
CADH2_HUMANARVC_HUMANHPRD11058098 details
CADH2_HUMANNMDE4_HUMANHPRD10862698 details
CADH2_HUMANLRRC7_HUMANHPRD11729199 details
CADH2_HUMANRHG32_HUMANHPRD12531901 details
CADH2_HUMANNMDZ1_HUMANHPRD10862698 details
CADH2_HUMANCTND2_HUMANHPRD9971746 details