Entity Details

Primary name PUR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22102
EntryNamePUR2_HUMAN
FullNameTrifunctional purine biosynthetic protein adenosine-3
TaxID9606
Evidenceevidence at protein level
Length1010
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesGART

GO terms

Show/Hide Table
GOName
GO:0003360 brainstem development
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006544 glycine metabolic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0010033 response to organic substance
GO:0010035 response to inorganic substance
GO:0021549 cerebellum development
GO:0021987 cerebral cortex development
GO:0046084 adenine biosynthetic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046872 metal ion binding
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000115 Phosphoribosylglycinamide synthetaseFamilyFamily
IPR001555 Phosphoribosylglycinamide formyltransferase, active siteSiteActive site
IPR002376 Formyl transferase, N-terminalDomainDomain
IPR004607 Phosphoribosylglycinamide formyltransferaseFamilyFamily
IPR004733 Phosphoribosylformylglycinamidine cyclo-ligaseFamilyFamily
IPR010918 PurM-like, C-terminal domainDomainDomain
IPR011054 Rudiment single hybrid motifFamilyHomologous superfamily
IPR011761 ATP-grasp foldDomainDomain
IPR013815 ATP-grasp fold, subdomain 1FamilyHomologous superfamily
IPR016185 Pre-ATP-grasp domain superfamilyFamilyHomologous superfamily
IPR016188 PurM-like, N-terminal domainDomainDomain
IPR020559 Phosphoribosylglycinamide synthetase, conserved siteSiteConserved site
IPR020560 Phosphoribosylglycinamide synthetase, C-domainDomainDomain
IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domainDomainDomain
IPR020562 Phosphoribosylglycinamide synthetase, N-terminalDomainDomain
IPR036477 Formyl transferase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036676 PurM-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036921 PurM-like, N-terminal domain superfamilyFamilyHomologous superfamily
IPR037123 Phosphoribosylglycinamide synthetase, C-domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00642 PemetrexedDrugbanksmall molecule
DB02236 Glycinamide RibonucleotideDrugbanksmall molecule
DB03546 N-({4-[(1R)-4-[(2R,4S,5S)-2,4-diamino-6-oxohexahydropyrimidin-5-yl]-1-(2,2,2-trifluoro-1,1-dihydroxyethyl)butyl]phenyl}carbonyl)-L-glutamic acidDrugbanksmall molecule