Entity Details

Primary name P5CR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP32322
EntryNameP5CR1_HUMAN
FullNamePyrroline-5-carboxylate reductase 1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length319
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesPYCR1

GO terms

Show/Hide Table
GOName
GO:0004735 pyrroline-5-carboxylate reductase activity
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006561 proline biosynthetic process
GO:0009064 glutamine family amino acid metabolic process
GO:0034599 cellular response to oxidative stress
GO:0042802 identical protein binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0055129 L-proline biosynthetic process
GO:1903206 negative regulation of hydrogen peroxide-induced cell death

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion

Domains

Show/Hide Table
DomainNameCategoryType
IPR000304 Pyrroline-5-carboxylate reductaseFamilyFamily
IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminalDomainDomain
IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domainDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule