Entity Details

Primary name CDN1C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49918
EntryNameCDN1C_HUMAN
FullNameCyclin-dependent kinase inhibitor 1C
TaxID9606
Evidenceevidence at protein level
Length316
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCDKN1C

GO terms

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GOName
GO:0004860 protein kinase inhibitor activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033673 negative regulation of kinase activity
GO:0042326 negative regulation of phosphorylation
GO:0044877 protein-containing complex binding
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0050680 negative regulation of epithelial cell proliferation
GO:1904030 negative regulation of cyclin-dependent protein kinase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003175 Cyclin-dependent kinase inhibitor domainDomainDomain
IPR029842 Cyclin-dependent kinase inhibitor 1CFamilyFamily

Diseases

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Disease IDSourceNameDescription
614732 OMIMIntrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE)A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis. The disease is caused by variants affecting the gene represented in this entry.
130650 OMIMBeckwith-Wiedemann syndrome (BWS)A disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. The disease is caused by variants affecting the gene represented in this entry.

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
CDN1C_HUMANCDK4_HUMANBioGRID, HPRD, IntAct10713702 9106657 details
CDN1C_HUMANMCM7_HUMANMINT16289477 details
CDN1C_HUMANCCNE2_HUMANBioGRID, HPRD, IntAct9840943 details
CDN1C_HUMANPCNA_HUMANBioGRID, HPRD, UniProt22634751 9465025 details
CDN1C_HUMANCCND1_HUMANBioGRID, IntAct10713702 10764802 28514442 details
CDN1C_HUMANLIMK1_HUMANBioGRID, HPRD14530263 details
CDN1C_HUMANMYBB_HUMANBioGRID12947099 details
CDN1C_HUMANSKP2_HUMANBioGRID, HPRD12925736 19686743 details
CDN1C_HUMANMYOD1_HUMANBioGRID, HPRD10764802 details
CDN1C_HUMANRB_HUMANBioGRID10486249 details
CDN1C_HUMANAKT1_HUMANBioGRID23421998 details
CDN1C_HUMANCDN1C_HUMANBioGRID10713702 details
CDN1C_HUMANVHL_HUMANBioGRID28425505 details
CDN1C_HUMANFXL12_HUMANBioGRID, HPRD, MINT18660753 details
CDN1C_HUMANCCNA2_HUMANBioGRID, IntAct12947099 26186194 26496610 28514442 details
CDN1C_HUMANRBL1_HUMANBioGRID12947099 details
CDN1C_HUMANP53_HUMANBioGRID12665691 details
CDN1C_HUMANCSN5_HUMANBioGRID26606000 details
CDN1C_HUMANASCL1_HUMANBioGRID19590511 details
CDN1C_HUMANNDF6_HUMANBioGRID19590511 details
CDN1C_HUMANNDF1_HUMANBioGRID19590511 details
CDN1C_HUMANCDK7_HUMANBioGRID20106982 details
CDN1C_HUMANCDK9_HUMANBioGRID20106982 details
CDN1C_HUMANRPB1_HUMANBioGRID20106982 details
CDN1C_HUMANE2F1_HUMANBioGRID20106982 details
CDN1C_HUMANE2F3_HUMANBioGRID20106982 details
CDN1C_HUMANCDN2A_HUMANBioGRID20106982 details
CDN1C_HUMANARF_HUMANBioGRID20106982 details
CDN1C_HUMANNR4A2_HUMANHPRD14671317 details