Entity Details

Primary name PP2BA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08209
EntryNamePP2BA_HUMAN
FullNameSerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPPP3CA

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001975 response to amphetamine
GO:0004722 protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0006470 protein dephosphorylation
GO:0006606 protein import into nucleus
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007420 brain development
GO:0007568 aging
GO:0014883 transition between fast and slow fiber
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016018 cyclosporin A binding
GO:0016311 dephosphorylation
GO:0019897 extrinsic component of plasma membrane
GO:0019899 enzyme binding
GO:0030018 Z disc
GO:0030335 positive regulation of cell migration
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0033555 multicellular organismal response to stress
GO:0035562 negative regulation of chromatin binding
GO:0036057 slit diaphragm
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042110 T cell activation
GO:0042383 sarcolemma
GO:0043197 dendritic spine
GO:0043403 skeletal muscle tissue regeneration
GO:0044877 protein-containing complex binding
GO:0045785 positive regulation of cell adhesion
GO:0045807 positive regulation of endocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0048741 skeletal muscle fiber development
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0051592 response to calcium ion
GO:0060079 excitatory postsynaptic potential
GO:0070262 peptidyl-serine dephosphorylation
GO:0071333 cellular response to glucose stimulus
GO:0097720 calcineurin-mediated signaling
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099170 postsynaptic modulation of chemical synaptic transmission
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905205 positive regulation of connective tissue replacement

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphataseDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR041751 PP2B, metallophosphatase domainDomainDomain
IPR043360 PP2BFamilyFamily

Diseases

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Disease IDSourceNameDescription
617711 OMIMEpileptic encephalopathy, infantile or early childhood, 1 (IECEE1)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. IECEE1 is an autosomal dominant condition with onset of seizures between the first weeks and first years of life. The disease is caused by variants affecting the gene represented in this entry.
618265 OMIMArthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development (ACCIID)An autosomal dominant disease characterized by moderate to severe intellectual disability, craniosynostosis, cleft palate, micrognathia, arthrogryposis, and short stature. Some patients may present bone abnormalities and generalized seizures. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08231 Myristic acidDrugbanksmall molecule

Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
PP2BA_HUMANGRB2_HUMANBioGRID, IntAct, MINT12577067 17474147 21900206 details
PP2BA_HUMANCP074_HUMANBioGRID, HPRD, IntAct16189514 21516116 25416956 32296183 details
PP2BA_HUMANCANB1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11439183 19896943 21516116 22343722 22939629 23468591 24954618 25416956 26186194 26264872 26871637 27880917 28514442 32296183 32814053 8524402 details
PP2BA_HUMANABL1_HUMANIntAct17474147 details
PP2BA_HUMANLASP1_HUMANIntAct22665060 details
PP2BA_HUMANJUN_HUMANBioGRID, MINT17215518 25609649 details
PP2BA_HUMANSHAN2_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANAMPH_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANARMT1_HUMANBioGRID, IntAct26344197 27880917 32296183 details
PP2BA_HUMANTENS4_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANTRI72_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANIP3KB_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANABI2_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANU119A_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANAKAP5_HUMANBioGRID, DIP, HPRD, IntAct22343722 32296183 7528941 9765270 details
PP2BA_HUMANF167A_HUMANBioGRID, IntAct32296183 details
PP2BA_HUMANNFAC1_HUMANBioGRID, DIP, IntAct23468591 24954618 28514442 details
PP2BA_HUMANRCAN2_HUMANBioGRID, HPRD, IntAct10861295 12102656 26186194 28514442 details
PP2BA_HUMANRCAN1_HUMANBioGRID, HPRD, IntAct10861295 12063245 23118980 26186194 27880917 28514442 details
PP2BA_HUMANNFAC2_HUMANDIP24954618 details
PP2BA_HUMANLMTK1_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANERBB3_HUMANMINT28065597 details
PP2BA_HUMANFGFR4_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANRYK_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANPTK7_HUMANBioGRID, MINT28065597 details
PP2BA_HUMANSODC_HUMANHPRD, IntAct11513882 32814053 details
PP2BA_HUMANCABIN_HUMANBioGRID, HPRD11714752 9655484 details
PP2BA_HUMANMYOZ2_HUMANBioGRID, HPRD11114196 11842093 details
PP2BA_HUMANPSA6_HUMANBioGRID21420386 details
PP2BA_HUMANCSEN_HUMANBioGRID17102134 details
PP2BA_HUMANMARH7_HUMANBioGRID24905733 details
PP2BA_HUMANUBE4B_HUMANBioGRID29326975 details
PP2BA_HUMANKLHL3_HUMANBioGRID30718414 details
PP2BA_HUMANSC6A4_HUMANBioGRID24107951 details
PP2BA_HUMANPLAC8_HUMANBioGRID32296183 details
PP2BA_HUMANCANB2_HUMANBioGRID32296183 details
PP2BA_HUMANSYUA_HUMANBioGRID29409956 details
PP2BA_HUMANOGT1_HUMANBioGRID32994395 details
PP2BA_HUMANCHIP_HUMANBioGRID29326975 details
PP2BA_HUMANUBP14_HUMANMINT19896943 details
PP2BA_HUMANGCR_HUMANIntAct20195357 details
PP2BA_HUMANRXRB_HUMANIntAct20195357 details
PP2BA_HUMANUTRN_HUMANDIP18838687 details
PP2BA_HUMANDISC1_HUMANIntAct31413325 details
PP2BA_HUMANPPIA_HUMANBioGRID12218175 details
PP2BA_HUMANADRB2_HUMANBioGRID9880537 details
PP2BA_HUMANBCL2_HUMANBioGRID, HPRD19706527 7593193 9109491 details
PP2BA_HUMANMYOZ1_HUMANBioGRID11114196 details
PP2BA_HUMANAKT1_HUMANBioGRID20605778 details
PP2BA_HUMANPHLP2_HUMANBioGRID20605778 details
PP2BA_HUMANPTEN_HUMANBioGRID20605778 details
PP2BA_HUMANPDE4D_HUMANBioGRID20647544 details
PP2BA_HUMANTRAF3_HUMANBioGRID22715070 details
PP2BA_HUMANCRTC2_HUMANBioGRID, HPRD15454081 27990298 details
PP2BA_HUMANPP2BA_HUMANHPRD12574411 details
PP2BA_HUMANGBRA1_HUMANHPRD12574411 details
PP2BA_HUMANGBRG2_HUMANHPRD12574411 details
PP2BA_HUMANKPCZ_HUMANHPRD12021260 details
PP2BA_HUMANFKB1A_HUMANHPRD7543369 8524402 details
PP2BA_HUMANGBRB2_HUMANHPRD12574411 details
PP2BA_HUMANCASP3_HUMANHPRD11478781 details
PP2BA_HUMANFKBP8_HUMANHPRD12510191 15757646 details
PP2BA_HUMANSYNJ1_HUMANHPRD14704270 details
PP2BA_HUMANMYOZ3_HUMANHPRD11842093 details
PP2BA_HUMANBAD_HUMANHPRD10195903 details
PP2BA_HUMANAT2B4_HUMANHPRD15955804 details