Entity Details

Primary name DYR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13627
EntryNameDYR1A_HUMAN
FullNameDual specificity tyrosine-phosphorylation-regulated kinase 1A
TaxID9606
Evidenceevidence at protein level
Length763
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDYRK1A

GO terms

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GOName
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0003713 transcription coactivator activity
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0007399 nervous system development
GO:0007623 circadian rhythm
GO:0008092 cytoskeletal protein binding
GO:0015631 tubulin binding
GO:0016032 viral process
GO:0016607 nuclear speck
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030424 axon
GO:0030425 dendrite
GO:0031115 negative regulation of microtubule polymerization
GO:0033120 positive regulation of RNA splicing
GO:0034205 amyloid-beta formation
GO:0036289 peptidyl-serine autophosphorylation
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042802 identical protein binding
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043621 protein self-association
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0048025 negative regulation of mRNA splicing, via spliceosome
GO:0048156 tau protein binding
GO:0050321 tau-protein kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/BFamilyFamily
IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614104 OMIMMental retardation, autosomal dominant 7 (MRD7)A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07608 N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
DYR1A_HUMAN1433E_HUMANBioGRID, HPRD, MINT15369779 30773093 details
DYR1A_HUMAN1433B_HUMANBioGRID, HPRD, IntAct17229891 17353931 30773093 details
DYR1A_HUMANDCAF7_HUMANBioGRID, IntAct, MINT14593110 20940704 21777625 23602568 25342745 27173435 27307198 27705803 28514442 30137413 30773093 30979931 31024071 unassigned1312 details
DYR1A_HUMANLZTS2_HUMANBioGRID, IntAct, MINT23602568 26186194 26949739 28514442 29395067 30773093 details
DYR1A_HUMANRB_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANCBP_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANRN169_HUMANBioGRID, IntAct, MINT23602568 26949739 28325877 30104380 30773093 30979931 31024071 details
DYR1A_HUMANTROAP_HUMANBioGRID, IntAct, MINT23602568 26949739 30773093 31024071 details
DYR1A_HUMANRBL1_HUMANBioGRID, IntAct23602568 details
DYR1A_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
DYR1A_HUMANDYR1A_HUMANBioGRID, DIP, HPRD17229891 23665168 26735018 30137413 30773093 30979931 31024071 details
DYR1A_HUMANSRSF4_HUMANBioGRID14623875 details
DYR1A_HUMANCCNL2_HUMANBioGRID, HPRD14623875 details
DYR1A_HUMANSRSF5_HUMANBioGRID14623875 details
DYR1A_HUMANCLASR_HUMANBioGRID14623875 details
DYR1A_HUMANSRSF1_HUMANBioGRID14623875 details
DYR1A_HUMANDYN1_HUMANBioGRID11877424 19722700 details
DYR1A_HUMANH2B1B_HUMANBioGRID10644696 details
DYR1A_HUMANH31_HUMANBioGRID10644696 details
DYR1A_HUMANH4_HUMANBioGRID10644696 details
DYR1A_HUMANAMPH_HUMANBioGRID16733250 details
DYR1A_HUMANLATS2_HUMANBioGRID21498571 details
DYR1A_HUMANLIN52_HUMANBioGRID21498571 30206359 30773093 details
DYR1A_HUMANSYUA_HUMANBioGRID16959772 details
DYR1A_HUMANA4_HUMANBioGRID21832049 details
DYR1A_HUMANID2_HUMANBioGRID26735018 details
DYR1A_HUMANPRKN_HUMANBioGRID25963095 details
DYR1A_HUMANPEA15_HUMANBioGRID24710276 details
DYR1A_HUMANTAU_HUMANBioGRID11311121 17906291 details
DYR1A_HUMANEI2BE_HUMANBioGRID11311121 details
DYR1A_HUMANPHYIP_HUMANHPRD15694837 details
DYR1A_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 28514442 details
DYR1A_HUMAN1433S_HUMANBioGRID, MINT15778465 details
DYR1A_HUMANHIPK2_HUMANBioGRID, MINT20940704 details
DYR1A_HUMANSIR1_HUMANUniProt20167603 details
DYR1A_HUMANF117B_HUMANBioGRID, IntAct23602568 28514442 30773093 31024071 details
DYR1A_HUMANEP300_HUMANBioGRID, IntAct23602568 30137413 details
DYR1A_HUMANCLH1_HUMANBioGRID19722700 details
DYR1A_HUMANSH3G2_HUMANBioGRID19722700 details
DYR1A_HUMANM3K5_HUMANBioGRID22110360 details
DYR1A_HUMANEGLN2_HUMANBioGRID26735018 details
DYR1A_HUMANARIP4_HUMANBioGRID26412716 30137413 30773093 details
DYR1A_HUMANFBW1A_HUMANBioGRID27807027 details
DYR1A_HUMANXRN1_HUMANBioGRID29395067 30773093 details
DYR1A_HUMANMDM2_HUMANBioGRID30910997 details
DYR1A_HUMANH2AX_HUMANBioGRID30979931 details
DYR1A_HUMANTTP_HUMANBioGRID29395067 details
DYR1A_HUMANCREB1_HUMANHPRD15694837 details
DYR1A_HUMANGLI1_HUMANHPRD12138125 details
DYR1A_HUMANSF3B1_HUMANHPRD16512921 details
DYR1A_HUMANFOXO1_HUMANHPRD11311120 details