Entity Details

Primary name LPIN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14693
EntryNameLPIN1_HUMAN
FullNamePhosphatidate phosphatase LPIN1
TaxID9606
Evidenceevidence at protein level
Length890
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLPIN1

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006642 triglyceride mobilization
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0007077 mitotic nuclear membrane disassembly
GO:0008195 phosphatidate phosphatase activity
GO:0009062 fatty acid catabolic process
GO:0019432 triglyceride biosynthetic process
GO:0031100 animal organ regeneration
GO:0031642 negative regulation of myelination
GO:0031965 nuclear membrane
GO:0032869 cellular response to insulin stimulus
GO:0044255 cellular lipid metabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046473 phosphatidic acid metabolic process
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1903730 regulation of phosphatidate phosphatase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Nucleus membrane

Domains

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DomainNameCategoryType
IPR007651 Lipin, N-terminalDomainDomain
IPR013209 Lipin/Ned1/Smp2 (LNS2)DomainDomain
IPR026058 LIPIN familyFamilyFamily
IPR028794 Phosphatidate phosphatase LPIN1FamilyFamily
IPR031315 LNS2/PITPDomainDomain
IPR031703 Lipin, middle domainDomainDomain
IPR036412 HAD-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
268200 OMIMMyoglobinuria, acute recurrent, autosomal recessive (ARARM)Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. The disease is caused by variants affecting the gene represented in this entry.