Entity Details

Primary name OGG1
Entity type gene
Source Source Link

Details

PrimaryID4968
RefseqGeneNG_012106
SymbolOGG1
Name8-oxoguanine DNA glycosylase
Chromosome3
Location3p25.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsOGG1_HUMAN

GO terms

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GOName
GO:0002526 acute inflammatory response
GO:0003684 damaged DNA binding
GO:0004519 endonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006284 base-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006287 base-excision repair, gap-filling
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0008017 microtubule binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
GO:0032355 response to estradiol
GO:0032357 oxidized purine DNA binding
GO:0032991 protein-containing complex
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0045007 depurination
GO:0045008 depyrimidination
GO:0045471 response to ethanol
GO:0051593 response to folic acid
GO:0071276 cellular response to cadmium ion
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:1901291 negative regulation of double-strand break repair via single-strand annealing

Diseases

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Disease IDSourceNameDescription
144700 OMIMRenal cell carcinoma (RCC)Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

15 interactions