Entity Details

Primary name HAMP
Entity type gene
Source Source Link

Details

PrimaryID57817
RefseqGeneNG_011563
SymbolHAMP
Namehepcidin antimicrobial peptide
Chromosome19
Location19q13.12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-05-29
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsHEPC_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002092 positive regulation of receptor internalization
GO:0002262 myeloid cell homeostasis
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005507 copper ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0006879 cellular iron ion homeostasis
GO:0006953 acute-phase response
GO:0006955 immune response
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007568 aging
GO:0010039 response to iron ion
GO:0010043 response to zinc ion
GO:0014704 intercalated disc
GO:0031640 killing of cells of other organism
GO:0032413 negative regulation of ion transmembrane transporter activity
GO:0033189 response to vitamin A
GO:0034760 negative regulation of iron ion transmembrane transport
GO:0036017 response to erythropoietin
GO:0042742 defense response to bacterium
GO:0043032 positive regulation of macrophage activation
GO:0045179 apical cortex
GO:0045471 response to ethanol
GO:0045779 negative regulation of bone resorption
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0060586 multicellular organismal iron ion homeostasis
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0071222 cellular response to lipopolysaccharide
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071481 cellular response to X-ray
GO:0097421 liver regeneration
GO:0097690 iron ion transmembrane transporter inhibitor activity
GO:1902916 positive regulation of protein polyubiquitination
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903413 cellular response to bile acid
GO:1904039 negative regulation of iron export across plasma membrane
GO:1904255 negative regulation of iron ion transmembrane transporter activity
GO:1904479 negative regulation of intestinal absorption
GO:1990641 response to iron ion starvation
GO:2000646 positive regulation of receptor catabolic process

Diseases

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Disease IDSourceNameDescription
613313 OMIMHemochromatosis 2B (HFE2B)A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
HAMPCKAP4BioGRID, IntAct21988832 details
HAMPVKORC1BioGRID21103663 details
HAMPGLP1RBioGRID28597972 details
HAMPSLC40A1HPRD15514116 details