Entity Details

Primary name P3H1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ32P28
EntryNameP3H1_HUMAN
FullNameProlyl 3-hydroxylase 1
TaxID9606
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated2006-06-27
DateModified2021-06-02

Ontological Relatives

GenesP3H1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0006457 protein folding
GO:0008285 negative regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0018126 protein hydroxylation
GO:0019797 procollagen-proline 3-dioxygenase activity
GO:0030199 collagen fibril organization
GO:0031418 L-ascorbic acid binding
GO:0032963 collagen metabolic process
GO:0032991 protein-containing complex
GO:0050708 regulation of protein secretion
GO:0050821 protein stabilization
GO:0060348 bone development
GO:0061077 chaperone-mediated protein folding
GO:0070062 extracellular exosome
GO:1901874 negative regulation of post-translational protein modification

Subcellular Location

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Subcellular Location
Endoplasmic reticulum
Secreted

Domains

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DomainNameCategoryType
IPR005123 Oxoglutarate/iron-dependent dioxygenaseDomainDomain
IPR006620 Prolyl 4-hydroxylase, alpha subunitDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR039575 Prolyl 3-hydroxylaseFamilyFamily
IPR039837 Prolyl 3-hydroxylase 1FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB00139 Succinic acidDrugbanksmall molecule
DB00172 ProlineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
P3H1_HUMANCDC42_HUMANBioGRID31478661 details
P3H1_HUMANGLUT4_HUMANBioGRID, HPRD16396496 details