Entity Details

Primary name NOG
Entity type gene
Source Source Link

Details

PrimaryID9241
RefseqGeneNG_011958
SymbolNOG
Namenoggin
Chromosome17
Location17q22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-03-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNOGG_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001706 endoderm formation
GO:0001707 mesoderm formation
GO:0001837 epithelial to mesenchymal transition
GO:0001839 neural plate morphogenesis
GO:0001843 neural tube closure
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0007399 nervous system development
GO:0008045 motor neuron axon guidance
GO:0009953 dorsal/ventral pattern formation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0019955 cytokine binding
GO:0021510 spinal cord development
GO:0021533 cell differentiation in hindbrain
GO:0021983 pituitary gland development
GO:0030336 negative regulation of cell migration
GO:0030514 negative regulation of BMP signaling pathway
GO:0035019 somatic stem cell population maintenance
GO:0038098 sequestering of BMP from receptor via BMP binding
GO:0042060 wound healing
GO:0042474 middle ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048318 axial mesoderm development
GO:0048570 notochord morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048712 negative regulation of astrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051216 cartilage development
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060173 limb development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060302 negative regulation of cytokine activity
GO:0060325 face morphogenesis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412 ventricular septum morphogenesis
GO:0060425 lung morphogenesis
GO:0060513 prostatic bud formation
GO:0060676 ureteric bud formation
GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0061037 negative regulation of cartilage development
GO:0061053 somite development
GO:0061312 BMP signaling pathway involved in heart development
GO:0061384 heart trabecula morphogenesis
GO:0061626 pharyngeal arch artery morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0090193 positive regulation of glomerulus development
GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:2000313 regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:2001234 negative regulation of apoptotic signaling pathway

Diseases

Show/Hide Table
Disease IDSourceNameDescription
611377 OMIMBrachydactyly B2 (BDB2)A form of brachydactyly characterized by hypoplasia/aplasia of distal phalanges in combination with distal symphalangism, fusion of carpal/tarsal bones and partial cutaneous syndactyly. The disease is caused by variants affecting the gene represented in this entry.
186570 OMIMTarsal-carpal coalition syndrome (TCC)Autosomal dominant disorder characterized by fusion of the carpals, tarsals and phalanges, short first metacarpals causing brachydactyly, and humeroradial fusion. TCC is allelic to SYM1, and different mutations in NOG can result in either TCC or SYM1 in different families. The disease is caused by variants affecting the gene represented in this entry.
184460 OMIMStapes ankylosis with broad thumb and toes (SABTS)An autosomal dominant disorder characterized by hyperopia, a hemicylindrical nose, broad thumbs, great toes, and other minor skeletal anomalies but lacked carpal and tarsal fusion and symphalangism. The disease is caused by variants affecting the gene represented in this entry.
185800 OMIMSymphalangism, proximal 1A (SYM1A)A disease characterized by the hereditary absence of the proximal interphalangeal joints. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conductive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone. The disease is caused by variants affecting the gene represented in this entry.
186500 OMIMMultiple synostoses syndrome 1 (SYNS1)A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
NOGBMP7BioGRID, HPRD, IntAct12478285 details
NOGBMP2HPRD, MINT10657699 15064755 19804412 details
NOGGDF5UniProt16127465 details
NOGNOGBioGRID12478285 details
NOGBMP4HPRD10657699 11706034 details
NOGBMP5HPRD11580864 details