Entity Details

Primary name PARD3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TEW0
EntryNamePARD3_HUMAN
FullNamePartitioning defective 3 homolog
TaxID9606
Evidenceevidence at protein level
Length1356
SequenceStatuscomplete
DateCreated2003-05-16
DateModified2021-06-02

Ontological Relatives

GenesPARD3

GO terms

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GOName
GO:0000226 microtubule cytoskeleton organization
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005923 bicellular tight junction
GO:0005938 cell cortex
GO:0006612 protein targeting to membrane
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007409 axonogenesis
GO:0008104 protein localization
GO:0008356 asymmetric cell division
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0012505 endomembrane system
GO:0016324 apical plasma membrane
GO:0019903 protein phosphatase binding
GO:0022011 myelination in peripheral nervous system
GO:0030010 establishment of cell polarity
GO:0030054 cell junction
GO:0031643 positive regulation of myelination
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0032991 protein-containing complex
GO:0033269 internode region of axon
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043296 apical junction complex
GO:0044295 axonal growth cone
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0051660 establishment of centrosome localization
GO:0060341 regulation of cellular localization
GO:0065003 protein-containing complex assembly
GO:0070830 bicellular tight junction assembly
GO:0090162 establishment of epithelial cell polarity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR021922 Par3/HAL, N-terminalDomainDomain
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
182940 OMIMNeural tube defects (NTD)Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
PARD3_HUMANPAR6A_HUMANBioGRID, HPRD, IntAct, MINT11257119 12459187 14676191 17057644 22883624 26496610 details
PARD3_HUMANKPCI_HUMANBioGRID, HPRD, IntAct12459187 14676191 22883624 31980649 34079125 details
PARD3_HUMANJAM1_HUMANBioGRID, MINT12953056 17057644 details
PARD3_HUMANJAM2_HUMANBioGRID, MINT12953056 17057644 details
PARD3_HUMANJAM3_HUMANBioGRID, MINT12953056 17057644 details
PARD3_HUMANTITIN_HUMANBioGRID, IntAct23414517 details
PARD3_HUMANMYPC3_HUMANIntAct21569246 details
PARD3_HUMANNECT3_HUMANBioGRID, HPRD12515806 details
PARD3_HUMANSMAD7_HUMANBioGRID, HPRD12650946 details
PARD3_HUMANSMAD4_HUMANBioGRID, HPRD12650946 details
PARD3_HUMANSMAD1_HUMANBioGRID12650946 details
PARD3_HUMANSMAD2_HUMANBioGRID, HPRD12650946 details
PARD3_HUMANSMAD3_HUMANBioGRID, HPRD12650946 details
PARD3_HUMANDCAF7_HUMANBioGRID, IntAct14676191 27173435 unassigned1312 details
PARD3_HUMANPAR6B_HUMANBioGRID, HPRD, IntAct12459187 14676191 26186194 26496610 28514442 34079125 details
PARD3_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT14676191 15161933 28514442 details
PARD3_HUMANPAR6G_HUMANBioGRID, HPRD, IntAct12459187 14676191 34079125 details
PARD3_HUMANSTK11_HUMANHPRD, IntAct14676191 details
PARD3_HUMAN1433B_HUMANBioGRID, HPRD, IntAct, MINT14676191 15324660 17353931 24255178 28514442 details
PARD3_HUMANPLCB3_HUMANHPRD, MINT15782111 details
PARD3_HUMANEIF1B_HUMANIntAct17353931 details
PARD3_HUMANTIAM1_HUMANDIP, HPRD, MINT15723052 17053785 23263278 details
PARD3_HUMANLIMK2_HUMANHPRD, MINT16505165 17053785 details
PARD3_HUMANCSK_HUMANMINT17053785 details
PARD3_HUMAN1433S_HUMANBioGRID, MINT15778465 details
PARD3_HUMANCADH5_HUMANMINT17057644 details
PARD3_HUMANCTNA1_HUMANBioGRID, MINT17057644 34079125 details
PARD3_HUMANCTNB1_HUMANBioGRID, IntAct, MINT17057644 25241761 27684187 34079125 details
PARD3_HUMANP53_HUMANMINT22653443 details
PARD3_HUMANASPP2_HUMANBioGRID, DIP, IntAct23606740 24366813 25344754 28400336 34079125 details
PARD3_HUMANLATS1_HUMANBioGRID, IntAct24255178 26116754 34079125 details
PARD3_HUMANPP1A_HUMANBioGRID, IntAct26116754 28330616 details
PARD3_HUMANARPC2_HUMANDIP23263278 details
PARD3_HUMANKPCZ_HUMANBioGRID, IntAct12459187 31980649 details
PARD3_HUMANECT2_HUMANBioGRID15254234 details
PARD3_HUMANSIAH1_HUMANBioGRID21109632 details
PARD3_HUMANHSP7C_HUMANBioGRID18685789 details
PARD3_HUMANHSP76_HUMANBioGRID18685789 details
PARD3_HUMANCH60_HUMANBioGRID18685789 details
PARD3_HUMANPSME3_HUMANBioGRID18685789 details
PARD3_HUMANPSME2_HUMANBioGRID18685789 details
PARD3_HUMANRS3_HUMANBioGRID18685789 details
PARD3_HUMANRS18_HUMANBioGRID18685789 details
PARD3_HUMANPFKAP_HUMANBioGRID18685789 details
PARD3_HUMANIMA3_HUMANBioGRID18685789 details
PARD3_HUMANAN32E_HUMANBioGRID18685789 details
PARD3_HUMANZO1_HUMANBioGRID11257119 34079125 details
PARD3_HUMANVHL_HUMANBioGRID17101696 details
PARD3_HUMANRHG17_HUMANBioGRID16678097 details
PARD3_HUMANAMOT_HUMANBioGRID16678097 34079125 details
PARD3_HUMAN1433E_HUMANBioGRID17979178 34079125 details
PARD3_HUMANGAB1_HUMANBioGRID22883624 34079125 details
PARD3_HUMANMARK2_HUMANBioGRID22883624 34079125 details
PARD3_HUMANLZTS2_HUMANBioGRID29395067 34079125 details
PARD3_HUMANMEX3B_HUMANBioGRID29395067 details
PARD3_HUMANKPCG_HUMANHPRD14676191 details
PARD3_HUMANDYL1_HUMANHPRD14760703 details
PARD3_HUMANPARD3_HUMANHPRD14676191 details
PARD3_HUMANNECT1_HUMANHPRD12515806 details
PARD3_HUMANCDC42_HUMANHPRD10934474 details
PARD3_HUMANPLCB1_HUMANHPRD15782111 details
PARD3_HUMANINSC_HUMANHPRD16458856 details
PARD3_HUMANTIAM2_HUMANHPRD15723051 details