Entity Details

Primary name NR4A3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92570
EntryNameNR4A3_HUMAN
FullNameNuclear receptor subfamily 4 group A member 3
TaxID9606
Evidenceevidence at protein level
Length626
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesNR4A3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007369 gastrulation
GO:0008270 zinc ion binding
GO:0009444 pyruvate oxidation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010828 positive regulation of glucose transmembrane transport
GO:0019901 protein kinase binding
GO:0031100 animal organ regeneration
GO:0032765 positive regulation of mast cell cytokine production
GO:0035259 glucocorticoid receptor binding
GO:0035497 cAMP response element binding
GO:0035726 common myeloid progenitor cell proliferation
GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043303 mast cell degranulation
GO:0044320 cellular response to leptin stimulus
GO:0045333 cellular respiration
GO:0045444 fat cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046321 positive regulation of fatty acid oxidation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0061469 regulation of type B pancreatic cell proliferation
GO:0071376 cellular response to corticotropin-releasing hormone stimulus
GO:0071870 cellular response to catecholamine stimulus
GO:0097009 energy homeostasis
GO:1900625 positive regulation of monocyte aggregation
GO:1903208 negative regulation of hydrogen peroxide-induced neuron death
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:2000253 positive regulation of feeding behavior

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR003070 Orphan nuclear receptorFamilyFamily
IPR003072 Orphan nuclear receptor, NOR1 typeFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612219 OMIMEwing sarcoma (ES)A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1.

Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
NR4A3_HUMANKRA56_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANPCSK5_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANLCE2B_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA92_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR105_HUMANIntAct32296183 details
NR4A3_HUMANUBE3A_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANLCE2D_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANCDN2D_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANSMOC1_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANNECT2_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR411_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANMACOI_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA44_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANVASN_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANPPB1_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANTSN4_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR124_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANPIN1_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANCHRD_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA98_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR511_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANZN330_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANVWC2L_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMAN3BHS7_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR123_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANATL4_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA42_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANFBLN3_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA53_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKRA93_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANKR108_HUMANBioGRID, IntAct32296183 details
NR4A3_HUMANSIX3_HUMANBioGRID, HPRD, UniProt11173923 12543801 15523651 details
NR4A3_HUMANTIF1B_HUMANBioGRID19321449 details
NR4A3_HUMANCSN5_HUMANBioGRID, HPRD15604093 details
NR4A3_HUMANRECK_HUMANBioGRID32296183 details
NR4A3_HUMANKR101_HUMANBioGRID32296183 details
NR4A3_HUMANCP21A_HUMANBioGRID32296183 details
NR4A3_HUMANBCL2_HUMANMINT30455429 details
NR4A3_HUMANKDM5B_HUMANBioGRID19336002 details
NR4A3_HUMANKS6A1_HUMANHPRD16223362 details
NR4A3_HUMANVHL_HUMANHPRD18305400 details