Entity Details

Primary name TRPM7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96QT4
EntryNameTRPM7_HUMAN
FullNameTransient receptor potential cation channel subfamily M member 7
TaxID9606
Evidenceevidence at protein level
Length1865
SequenceStatuscomplete
DateCreated2004-12-07
DateModified2021-06-02

Ontological Relatives

GenesTRPM7

GO terms

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GOName
GO:0001726 ruffle
GO:0003779 actin binding
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006816 calcium ion transport
GO:0010961 cellular magnesium ion homeostasis
GO:0016340 calcium-dependent cell-matrix adhesion
GO:0017022 myosin binding
GO:0031032 actomyosin structure organization
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0051262 protein tetramerization
GO:0070266 necroptotic process
GO:0070588 calcium ion transmembrane transport
GO:0072507 divalent inorganic cation homeostasis
GO:0098655 cation transmembrane transport
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR004166 MHCK/EF2 kinaseDomainDomain
IPR005821 Ion transport domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR029601 Transient receptor potential cation channel subfamily M member 7FamilyFamily
IPR032415 TRPM, tetramerisation domainDomainDomain
IPR037162 TRPM, tetramerisation domain superfamilyFamilyHomologous superfamily
IPR041491 TRPM, SLOG domainDomainDomain

Diseases

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Disease IDSourceNameDescription
105500 OMIMAmyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1)A neurodegenerative disorder characterized by chronic, progressive and uniformly fatal amyotrophic lateral sclerosis and parkinsonism-dementia. Both diseases are known to occur in the same kindred, the same sibship and even the same individual. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB04447 1,4-DithiothreitolDrugbanksmall molecule
DB09481 Magnesium carbonateDrugbanksmall molecule
DB14513 MagnesiumSwissprotsmall molecule