Entity Details

Primary name PLCB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15120
EntryNamePLCB_HUMAN
FullName1-acyl-sn-glycerol-3-phosphate acyltransferase beta
TaxID9606
Evidenceevidence at protein level
Length278
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesAGPAT2

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0008544 epidermis development
GO:0016021 integral component of membrane
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0035579 specific granule membrane
GO:0042493 response to drug
GO:0043312 neutrophil degranulation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002123 Phospholipid/glycerol acyltransferaseDomainDomain
IPR004552 1-acyl-sn-glycerol-3-phosphate acyltransferaseDomainDomain

Diseases

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Disease IDSourceNameDescription
608594 OMIMCongenital generalized lipodystrophy 1 (CGL1)An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

7 interactions