Entity Details

Primary name SPEF2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9C093
EntryNameSPEF2_HUMAN
FullNameSperm flagellar protein 2
TaxID9606
Evidenceevidence at protein level
Length1822
SequenceStatuscomplete
DateCreated2007-08-21
DateModified2021-06-02

Ontological Relatives

GenesSPEF2

GO terms

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GOName
GO:0002177 manchette
GO:0003351 epithelial cilium movement involved in extracellular fluid movement
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0007283 spermatogenesis
GO:0007288 sperm axoneme assembly
GO:0036126 sperm flagellum
GO:0048705 skeletal system morphogenesis
GO:0048854 brain morphogenesis
GO:0060541 respiratory system development
GO:0097225 sperm midpiece

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001715 Calponin homology domainDomainDomain
IPR010441 CH-like domain in sperm proteinDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
618751 OMIMSpermatogenic failure 43 (SPGF43)An autosomal recessive infertility disorder characterized by asthenospermia due to multiple morphologic abnormalities of sperm flagella, including short, absent, coiled, and bent flagella. The disease is caused by variants affecting the gene represented in this entry.

Interactions

3 interactions