Entity Details

Primary name NOD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9HC29
EntryNameNOD2_HUMAN
FullNameNucleotide-binding oligomerization domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length1040
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesNOD2

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003779 actin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006952 defense response
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007254 JNK cascade
GO:0007584 response to nutrient
GO:0009595 detection of biotic stimulus
GO:0009986 cell surface
GO:0016045 detection of bacterium
GO:0016323 basolateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030277 maintenance of gastrointestinal epithelium
GO:0030544 Hsp70 protein binding
GO:0031982 vesicle
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032495 response to muramyl dipeptide
GO:0032498 detection of muramyl dipeptide
GO:0032500 muramyl dipeptide binding
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032991 protein-containing complex
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035556 intracellular signal transduction
GO:0038187 pattern recognition receptor activity
GO:0042742 defense response to bacterium
GO:0042834 peptidoglycan binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045335 phagocytic vesicle
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046645 positive regulation of gamma-delta T cell activation
GO:0046658 anchored component of plasma membrane
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050700 CARD domain binding
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071407 cellular response to organic cyclic compound
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090022 regulation of neutrophil chemotaxis
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1904417 positive regulation of xenophagy
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cytoplasm
Membrane
Mitochondrion

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Disease IDSourceNameDescription
186580 OMIMBlau syndrome (BLAUS)An autosomal dominant inflammatory disorder characterized by the formation of immune granulomas invading the skin, joints and eye. Other organs may be involved. Clinical manifestations are variable and include early-onset granulomatous arthritis, uveitis and skin rash. Blindness, joint destruction and visceral involvement have been reported in severe cases. The disease is caused by variants affecting the gene represented in this entry.
617321 OMIMYao syndrome (YAOS)An autoinflammatory disease characterized by periodic fever, dermatitis, polyarthritis, leg swelling, and gastrointestinal and sicca-like symptoms. YAOS is a complex disease with multifactorial inheritance. Disease susceptibility is associated with variants affecting the gene represented in this entry.
266600 OMIMInflammatory bowel disease 1 (IBD1)A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB13615 MifamurtideDrugbanksmall molecule

Interactions

77 interactions

InteractorPartnerSourcesPublicationsLink
NOD2_HUMANRIPK2_HUMANBioGRID, HPRD, IntAct, MINT11087742 15620648 19592251 21097508 21123652 21931826 22607974 22829933 26670046 27545878 27812135 details
NOD2_HUMANA16L1_HUMANBioGRID, MINT19898471 23376921 27273576 details
NOD2_HUMANTRI27_HUMANBioGRID, IntAct22829933 details
NOD2_HUMANTRIM8_HUMANIntAct22829933 details
NOD2_HUMANTRI50_HUMANIntAct22829933 details
NOD2_HUMANVIME_HUMANBioGRID, IntAct21699783 22684479 27812135 details
NOD2_HUMANGALT2_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANFIS1_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANTLE1_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANKAT5_HUMANBioGRID, IntAct21699783 details
NOD2_HUMAN2A5E_HUMANBioGRID, IntAct21699783 details
NOD2_HUMANNDUAD_HUMANIntAct15753091 details
NOD2_HUMANERBIN_HUMANBioGRID, HPRD, IntAct16203728 30833792 details
NOD2_HUMANXIAP_HUMANBioGRID, DIP, IntAct19667203 22607974 23818254 details
NOD2_HUMANM3K7_HUMANBioGRID15075345 17348859 17965022 details
NOD2_HUMANIRGM_HUMANBioGRID25891078 details
NOD2_HUMANCJ067_HUMANBioGRID27812135 details
NOD2_HUMANDOCK7_HUMANBioGRID27812135 details
NOD2_HUMANDCTN1_HUMANBioGRID27812135 details
NOD2_HUMANGOGB1_HUMANBioGRID27812135 details
NOD2_HUMANLARGN_HUMANBioGRID27812135 details
NOD2_HUMANANKH1_HUMANBioGRID27812135 details
NOD2_HUMANTRI41_HUMANBioGRID27812135 details
NOD2_HUMANCHMP5_HUMANBioGRID27812135 details
NOD2_HUMANENTR1_HUMANBioGRID27812135 details
NOD2_HUMANIKIP_HUMANBioGRID27812135 details
NOD2_HUMANK1C15_HUMANBioGRID27812135 details
NOD2_HUMANPP12C_HUMANBioGRID27812135 details
NOD2_HUMANLDOC1_HUMANBioGRID27812135 details
NOD2_HUMANP2R3B_HUMANBioGRID27812135 details
NOD2_HUMANCHM4B_HUMANBioGRID27812135 details
NOD2_HUMANPDLI5_HUMANBioGRID27812135 details
NOD2_HUMANTACC3_HUMANBioGRID27812135 details
NOD2_HUMANHAP1_HUMANBioGRID27812135 details
NOD2_HUMANANXA2_HUMANBioGRID27812135 details
NOD2_HUMANLUR1L_HUMANBioGRID27812135 details
NOD2_HUMANRL13A_HUMANBioGRID27812135 details
NOD2_HUMANPPBI_HUMANBioGRID27812135 details
NOD2_HUMANTERA_HUMANBioGRID27812135 details
NOD2_HUMANLMNA_HUMANBioGRID27812135 details
NOD2_HUMANWBP11_HUMANBioGRID27812135 details
NOD2_HUMANTNIP1_HUMANBioGRID27812135 details
NOD2_HUMANTPM1_HUMANBioGRID27812135 details
NOD2_HUMANTPM3_HUMANBioGRID27812135 details
NOD2_HUMANTPM4_HUMANBioGRID27812135 details
NOD2_HUMANSCYL1_HUMANBioGRID27812135 details
NOD2_HUMANCCL13_HUMANBioGRID27812135 details
NOD2_HUMANANR17_HUMANMINT23711367 details
NOD2_HUMANSGT1_HUMANBioGRID, DIP17420470 details
NOD2_HUMANCASP1_HUMANBioGRID, DIP15107016 18511561 details
NOD2_HUMANCASP4_HUMANDIP18511561 details
NOD2_HUMANNLRP1_HUMANDIP18511561 details
NOD2_HUMANOLFM4_HUMANDIP20534456 details
NOD2_HUMANS15A3_HUMANDIP24695226 details
NOD2_HUMANS15A4_HUMANDIP24695226 details
NOD2_HUMANSQSTM_HUMANBioGRID, IntAct23437331 30833792 details
NOD2_HUMANHSPB8_HUMANDIP31273097 details
NOD2_HUMANSHRPN_HUMANBioGRID, IntAct22607974 23818254 26670046 details
NOD2_HUMANHOIL1_HUMANBioGRID, IntAct22607974 23818254 26670046 details
NOD2_HUMANRNF31_HUMANBioGRID, IntAct22607974 23818254 26670046 27545878 details
NOD2_HUMANNLRC4_HUMANBioGRID, HPRD11472070 15107016 details
NOD2_HUMANBIRC2_HUMANBioGRID22607974 details
NOD2_HUMANBIRC3_HUMANBioGRID22607974 details
NOD2_HUMANNAT16_HUMANBioGRID22607974 details
NOD2_HUMANNEMO_HUMANBioGRID22607974 details
NOD2_HUMANRIPK1_HUMANBioGRID22607974 details
NOD2_HUMANCASPC_HUMANBioGRID18329614 details
NOD2_HUMANCSN6_HUMANBioGRID17337451 details
NOD2_HUMANTRAF4_HUMANBioGRID21097508 details
NOD2_HUMANTRAF6_HUMANBioGRID23437331 details
NOD2_HUMANNOD2_HUMANBioGRID23437331 details
NOD2_HUMANNOD1_HUMANBioGRID19898471 details
NOD2_HUMANUBC_HUMANBioGRID23300079 details
NOD2_HUMANCYLD_HUMANBioGRID26670046 27545878 details
NOD2_HUMANTNAP3_HUMANBioGRID26670046 details
NOD2_HUMANSPAT2_HUMANBioGRID27545878 details
NOD2_HUMANPRKN_HUMANBioGRID30378174 details