Entity Details

Primary name SCN8A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQD0
EntryNameSCN8A_HUMAN
FullNameSodium channel protein type 8 subunit alpha
TaxID9606
Evidenceevidence at protein level
Length1980
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesSCN8A

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006814 sodium ion transport
GO:0007399 nervous system development
GO:0007422 peripheral nervous system development
GO:0016021 integral component of membrane
GO:0019228 neuronal action potential
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030424 axon
GO:0031410 cytoplasmic vesicle
GO:0033268 node of Ranvier
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042552 myelination
GO:0043194 axon initial segment
GO:0086010 membrane depolarization during action potential

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR001696 Voltage gated sodium channel, alpha subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR008054 Voltage gated sodium channel, alpha-8 subunitFamilyFamily
IPR010526 Sodium ion transport-associatedDomainDomain
IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR043203 Voltage-gated cation channel calcium and sodiumFamilyFamily
IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gateDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB05232 TetrodotoxinDrugbanksmall molecule
DB05541 BrivaracetamDrugbanksmall molecule
DB09085 TetracaineDrugbanksmall molecule
DB09088 AmylocaineDrugbanksmall molecule
DB09342 PropoxycaineDrugbanksmall molecule
DB09345 PramocaineDrugbanksmall molecule
DB11186 PentoxyverineDrugbanksmall molecule
DB13269 Dichlorobenzyl alcoholDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech