Entity Details

Primary name DYR1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y463
EntryNameDYR1B_HUMAN
FullNameDual specificity tyrosine-phosphorylation-regulated kinase 1B
TaxID9606
Evidenceevidence at protein level
Length629
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesDYRK1B

GO terms

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GOName
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0006468 protein phosphorylation
GO:0007520 myoblast fusion
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0060612 adipose tissue development
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/BFamilyFamily
IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
615812 OMIMAbdominal obesity-metabolic syndrome 3 (AOMS3)A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule