Entity Details

Primary name CUBN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60494
EntryNameCUBN_HUMAN
FullNameCubilin
TaxID9606
Evidenceevidence at protein level
Length3623
SequenceStatuscomplete
DateCreated2006-02-07
DateModified2021-06-02

Ontological Relatives

GenesCUBN

GO terms

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GOName
GO:0001894 tissue homeostasis
GO:0005509 calcium ion binding
GO:0005765 lysosomal membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006898 receptor-mediated endocytosis
GO:0008203 cholesterol metabolic process
GO:0009235 cobalamin metabolic process
GO:0009617 response to bacterium
GO:0010008 endosome membrane
GO:0015889 cobalamin transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030139 endocytic vesicle
GO:0031232 extrinsic component of external side of plasma membrane
GO:0031419 cobalamin binding
GO:0031526 brush border membrane
GO:0034384 high-density lipoprotein particle clearance
GO:0038023 signaling receptor activity
GO:0038024 cargo receptor activity
GO:0042359 vitamin D metabolic process
GO:0042803 protein homodimerization activity
GO:0042953 lipoprotein transport
GO:0043202 lysosomal lumen
GO:0043235 receptor complex
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell membrane
Endosome
Lysosome membrane
Membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000859 CUB domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR024731 EGF domainDomainDomain
IPR028876 CubilinFamilyFamily
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00115 CyanocobalaminDrugbanksmall molecule
DB00200 HydroxocobalaminDrugbanksmall molecule